Faculty of Medicine University of Miyazaki

Summary

Our laboratory focuses on the pathogenesis of atherosclerosis, atherothrombosis, venous thromboembolism and thrombosis and hemostasis in obstetric disease. Thrombosis is a disease caused by a blood clot (thrombus). Thrombus may form in any part of the cardiovascular system, including arteries, veins the heart and the microcirculation. Arterial thrombi usually develop on the disrupted atherosclerotic lesions, causing myocardial infarction and ischemic stroke, etc. Venous thrombi likely occur in the lower limbs, which is a major cause of pulmonary thromboembolism. In this way, the thrombi can lead to serious complications. However, the mechanisms of thrombus formation and propagation remain unclear, because many factors, such as vessel wall constituents, local hemorheology, systemic thrombogenicity, also immune and inflammatory reactions, are involved in the process. We are studying the issues from the viewpoint of human and experimental pathology.

Research Projects

1. Pathology of thrombosis
2. Mechanisms of thrombus formation
3. Atherogenesis and atherosclerotic plaque thrombogenicity
4. Imaging of atherosclerosis and thrombosis
5. Cancer-associated thrombosis and hemorrhage
6. Thrombosis and hemostasis in obstetric disease

Laboratory Techniques

1. Histological analysis
2. Rabbit models of atherosclerosis and thrombosis
3. Blood flow chamber
4. Cell culture
5. Imaging modalities

Publications

http://www.med.miyazaki-u.ac.jp/home/pathophysiology/works/