Faculty of Medicine University of Miyazaki

Chemistry

Position opening for Ph.D., M.S.

xuyan@med.miyazaki-u.ac.jp

http://www.med.miyazaki-u.ac.jp/MMCCHEM/index_e_link_e.html

Combing chemistry and biology, the long-term objective of our research is to investigate DNA and RNA conformational changes associated with biological events for further understanding the life phenomenon and benefit to human.

Project

  1. Understanding the structures and function of human telomere DNA and RNA by chemical approaches
  2. Developing various chemical methods to targeting human telomeres and telomerase for the treatment of cancer

Lab technique

Chemistry

  • Synthesis: artificial nucleic acid or functional molecule
Biotechnology
  • Gel electrophoresis
  • Polymerase chain reaction (PCR)
  • DNA array
  • Molecular Cloning
  • DNA sequencing
  • Southern, Northern, Western blotting

Publication

  1. Sci. Rep. 5, 13693, 2015.
  2. Bioorg. Med. Chem. 22, 4419, 2014.
  3. J. Am. Chem. Soc. 135, 14, 2013.
  4. J. Am. Chem. Soc. 135, 18786, 2013.
  5. Angew. Chem. Int. Ed. 52, 13681, 2013.
  6. J. Biol. Chem. 287,  41787, 2012.
  7. Angew. Chem. Int. Ed. 51, 13681, 2012.
  8. Nature Communications, 2(1), 2011.
  9. J. Am. Chem. Soc. 133, 19153, 2011.
  10. Proc. Natl. Acad. Sci. USA. 107, 14579, 2010.
  11. Nature Protocols 2, 78, 2007.