Combing chemistry and biology, the long-term objective of our research is to investigate DNA and RNA conformational changes associated with biological events for further understanding the life phenomenon and benefit to human.
Project
- Understanding the structures and function of human telomere DNA and RNA by chemical approaches
- Developing various chemical methods to targeting human telomeres and telomerase for the treatment of cancer
Lab technique
Chemistry
- Synthesis: artificial nucleic acid or functional molecule
Biotechnology
- Gel electrophoresis
- Polymerase chain reaction (PCR)
- DNA array
- Molecular Cloning
- DNA sequencing
- Southern, Northern, Western blotting
Publication
- Sci. Rep. 5, 13693, 2015.
- Bioorg. Med. Chem. 22, 4419, 2014.
- J. Am. Chem. Soc. 135, 14, 2013.
- J. Am. Chem. Soc. 135, 18786, 2013.
- Angew. Chem. Int. Ed. 52, 13681, 2013.
- J. Biol. Chem. 287, 41787, 2012.
- Angew. Chem. Int. Ed. 51, 13681, 2012.
- Nature Communications, 2(1), 2011.
- J. Am. Chem. Soc. 133, 19153, 2011.
- Proc. Natl. Acad. Sci. USA. 107, 14579, 2010.
- Nature Protocols 2, 78, 2007.