業績

2021年4月までの実績

Jayasindu Mathiyazhagan, Ramamoorthy Siva, Rama Jayaraj, Harishkumar Madhyastha 3, Gothandam Kodiveri Muthukaliannan. Preventive Effect of Combined Zingiber officinale and Terminalia chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition. Nutr Cancer. 2021 Apr 6;1-10. doi: 10.1080/01635581.2021.1903948.

Queen Intan Nurrahmah, Radha Madhyastha, Harishkumar Madhyastha, Bethasiwi Purbasari, Masugi Maruyama, Yuichi Nakajima. Retinoic acid abrogates LPS-induced inflammatory response via negative regulation of NF-kappa B/miR-21 signaling. Immunopharmacol Immunotoxicol. 2021 Mar 24;1-10. doi: 10.1080/08923973.2021.1902348.

Vishal Panchariya, Vishal Bhati, Harishkumar Madhyastha, Radha Madhyastha, Jagdish Prasad, Priyal Sharma, Paras Sharma, Harish, Mahesh Kumar Saini, Vishnu D Rajput, Yuichi Nakajima, S L Kothari, Vinod Singh Gour. Chromatic intervention and biocompatibility assay for biosurfactant derived from Balanites aegyptiaca (L.) Del. Sci Rep. 2021 Feb 18;11(1):4186. doi: 10.1038/s41598-021-83573-7.

Kaviyarasi Renu, Rituraj Chakraborty, Haritha Myakala, Rajeshwari Koti, Ademola C Famurewa, Harishkumar Madhyastha, Balachandar Vellingiri, Alex George, Abilash Valsala Gopalakrishnan. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) – induced hepatotoxicity – A review. Chemosphere. 2021 May; 271:129735. doi: 10.1016/j.chemosphere.2021.129735.

Radha Madhyastha, Harishkumar Madhyastha, Queen Intan Nurrahmah, Bethasiwi Purbasari, Masugi Maruyama & Yuichi Nakajima. MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles. Inflammation. Jan. 2021. doi: 10.1007/s10753-021-01415-0

R Ranjitha, K N Meghana, V G Dileep Kumar, Aarti S Bhatt, B K Jayanna, C R Ravikumar, Mysore Sridhar Santosh, H Madhyastha and K Sakai. Rapid photocatalytic degradation of cationic organic dyes using Li-doped Ni/NiO nanocomposites and their electrochemical performance. New J. Chem.,2021,45,796. doi:10.1039/d0nj05268j

Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, and Inderchand Manjubala. Characterization and In Vitro Evaluations of Injectable Calcium Phosphate Cement Doped with Magnesium and Strontium. ACS Omega 2021, 6, 4, 2477–2486. doi: 10.1021/acsomega.0c03927

Saravanan Krishnan, Deepthy Jayakumar, Harishkumar Madhyastha & Anju Chadha. The Complexity of Microbial Metal Nanoparticle Synthesis: A Study of Candida parapsilosis ATCC 7330 mediated Gold Nanoparticles Formation. Bio Nano Science. Jan. 2021 doi: 10.1007/s12668-021-00825-6

2020年の実績

Hidehiko Kikuchi, Kaori Harata, Harishkumar Madhyastha, Futoshi Kuribayashi. Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells. Biochemistry and Biophysics Reports Volume 25, March 2021, 100891 doi:10.1016/j.bbrep.2020.100891

Aya Shibata, Kaori Harata, Yuko Moriguchi, Risako Kanegawa, Ayaka Nagahira, Misaki Shigematsu, Yuri Takamura, Haruno Watanabe, Takefumi Sagara, Harishkumar Madhyastha and Hidehiko Kikuchi. Production and evaluation of the authentic milk bread using a lactose-utilizing yeast, Kluyveromyces marxianus. Current Topics in Biotechnology. Vol. 11, 2020

Meghana Matur, Harishkumar Madhyastha, T S Shruthi, Radha Madhyastha, S P Srinivas, P N Navya, Hemant Kumar Daima. Engineering bioactive surfaces on nanoparticles and their biological interactions. Sci Rep. 2020 Nov 12;10(1):19713. doi: 10.1038/s41598-020-75465-z.

Akhela Umapathi, Navya PN, Harishkumar Madhyastha, Mandeep Singh, Radha Madhyastha, Masugi Maruyama, Hemant Kumar Daima. Curcumin and isonicotinic acid hydrazide functionalized gold nanoparticles for selective anticancer action. Colloids and Surfaces A. Volume 607, 20 December 2020, 125484. doi:10.1016/j.colsurfa.2020.125484

Harishkumar Madhyastha, Radha Madhyastha, Abhishek Thakur, Sakai Kentaro, Abhimanyu Dev, Sneha Singh, Bistivalli Chandrashekharappa R, Hemanth Kumar, Orlando Acevedo, Yuichi Nakajima, Hemant Kumar Daima, Akhela Aradhya, Navya Nagaraj P, Masugi Maruyama. c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism. Colloids Surf B Biointerfaces. 2020 Oct; 194:111211. doi: 10.1016/j.colsurfb.2020.111211.

Akshay Bhatt, Kentaro Sakai, Radha Madhyastha, Masugi Murayama, Harishkumar Madhyastha, Subha Narayan Rath. Biosynthesis and characterization of nano magnetic hydroxyapatite (nMHAp): An accelerated approach using simulated body fluid for biomedical applications. Ceramics International on December 01, 2020. doi:10.1016/j.ceramint.2020.07.285

Madhyastha H, Halder S, Queen Intan N, Madhyastha R, Mohanapriya A, Sudhakaran R, Sajitha L. S, Banerjee K, Bethasiwi P, Daima H, Navya P N, Maruyama M and Nakajima Y. Surface refined AuQuercetin nanoconjugate stimulates dermal cell migration: possible implication in wound healing. RSC Advances 10(62):37683-37694. doi: 10.1039/d0ra06690g

Hidehiko Kikuchi, Kaori Harata, Chikage Kawai, Harishkumar Madhyastha, Akira Yamauchi, Futoshi Kuribayashi. Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils. Fundamental Toxicological Scie .7 (2020) 4. doi: 10.2131/fts.7.201

Kaviyarasi Renu, Anusha Saravanan, Anushree Elangovan, Sineka Ramesh, Sivakumar Annamalai, Arunraj Namachivayam, Praveena Abel, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vellingiri Balachandar, Abilash Valsala Gopalakrishnan. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity.p Life Sci. 2020 Nov 1;260:118438. doi: 10.1016/j.lfs.2020.118438.

Kaushita Banerjee, Harishkumar Madhyastha, Rajendra Sandur V, Manikandanath NT, Thiagarajan N, Padma Thiagarajan. Anti-inflammatory and wound healing potential of a clove oil emulsion. Colloids and Surfaces B: Biointerfaces Volume 193, September 2020, 111102. doi: 10.1016/j.colsurfb.2020.111102

2019年の実績

H. Kikuchi,H. Mimuro, H.Madhyastha and F. Kuribayashi. Chalcone skeleton promots transcription of gp91-phox gene but inhibits expression of gp91-phox protein and hydroxyl groups in hydroxychalcones participates in the stable expression of gp-91-Phox protein. Microbiol Immunol. 2019 Oct;63(10):438-443. doi: 10.1111/1348-0421.12732.

A Umapathi., N P Nagaraju, H Madhyastha, D Jain, S P Srinivas, V M Rotello, H K Daima. Highly efficient and selective antimicrobial isonicotinnylhydrazide-coated polyoxometalate-functionalized silver nanoparticles. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110522. doi: 10.1016/j.colsurfb.2019.110522.

R Ranjitha, A.S.Bhat, C R Ravikumar, M S Santhosh, B K Jayanna, H.P Nagaswarupa, K Sakai and H Madhyastha. Electroactive Li incorporated cobalt oxide nanostructures for photocatalytic applications. Mater. Res. Express 6 1150d6 Published 1 November 2019

S. Akiyoshi, H.Kikuchi, F. Kuribayashi, H.Madhyastha and H.Minami. Sulforaphane displays the growth inhibition cytotoxicity and enhancement of retinoic acid induced superoxide generating activity in human monoblastic U937 cells. Fundamental Toxicological Sciences. DOI:10.2131/fts.6.319

Navya PN, Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M, Srinivas SP,Jain D, Amin MH, Bhargava SK, Daima HK. Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide.Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:286-294. 10.1016/j.msec.2018.11.024

Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M. The pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin. J Nat Med. 2019 Jan;73(1):59-66. doi: 10.1007/s11418-018-1237-3.

Sharma P, Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M, Verma KS, Verma S, Prasad J, Kothari SL, Gour VS. An appraisal of cuticular wax of Calotropis procera (Ait.) R. Br.: Extraction, chemical composition, biosafety and application. J Hazard Mater. 2019 Apr 15;368:397-403. doi:10.1016/j.jhazmat.2019.01.067.

Madhyastha H, Madhyastha R, Nakajima Y, Daima HK, Navya PN, Maruyama M. An opinion on nanomedicine and toxico-cellular crosstalk: Considerations and Caveats. ScienceDirect. doi:10:p100-105. 2019

Queen Intan Nurrahmah, Radha Madhyastha, Hrishkumar Madhyastha, Yuichi Nakajima, Masugi Maruyama. Nuclear factor-kappa B and JNK mediate macrophage polarization shift induced by C-phycocyanin. Indian Journal of Experimental Biology. 57: p381-389. 2019

Khin Phyu Phyu, Phyo Wai Zin, Myo Nanda Aung, Mya Mar Lar, Yoshitaka Hishikawa, Masugi Maruyama, Hiroshi Yokota, Hitoshi Mochizuki, Kyaw Zin Thant, Khin Thet Wai, Yasunori Yano. Contamination of arsenic in drinking water in Ayeyarwady delta region, MYANMAR. World journal of Pharmaceutical and Life Sciences WJPLS. 5(8): 42-48. 2019

Mochizuki H, Phyu KP, Aung MN, Zin PW, Yano Y, Myint MZ, Thit WM, Yamamoto Y, Hishikawa Y, Thant KZ, Maruyama M, Kuroda Y. Peripheral neuropathy induced by drinking water contaminated with low-dose arsenic in Myanmar. Environ Health Prev Med. 2019 Apr 23;24(1):23. doi: 10.1186/s12199-019-0781-0.

2018年の実績

Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M. Deciphering the molecular events during arsenic induced transcription signal cascade activation in cellular milieu. Biometals. 2018 Feb;31(1):7-15. doi: 10.1007/s10534-017-0065-3.

Medha M. Ugru, Sanjana Sheshadri, Devendra Jain, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, P.N. Navya, Hemant Kumar Daima. Insight into the composition and surface corona reliant biological behaviour of quercetin engineered nanoparticles. Colloids and Surfaces A. 548:1-9. 2018 doi: 10.1016/j.colsurfa.2018.03.055

Ahmad A, Agus R, Massi MN, Natzir R, Madhyastha R, Madhyastha HK, Maruyama M. Cloning and expression of MPT83 gene from Mycobacterium tuberculosis in E. coli BL21 as vaccine candidate of tuberculosis: A preliminary study. J Genet Eng Biotechnol. 2018 Dec;16(2):335-340. doi: 10.1016/j.jgeb.2018.04.001.

Renu K, Madhyastha H, Madhyastha R, Maruyama M, Arunachlam S, V G A. Role of arsenic exposure in adipose tissue dysfunction and its possible implication in diabetes pathophysiology. Toxicol Lett. 2018 Mar 1;284:86-95. doi:10.1016/j.toxlet.

Renu K, Madhyastha H, Madhyastha R, Maruyama M, Vinayagam S, Valsala Gopalakrishnan A. Review on molecular and biochemical insights of arsenic-mediated male reproductive toxicity. Life Sci. 2018 Nov 1;212:37-58. doi:10.1016/j.lfs.2018.09.045.

2017年以前の実績

Chayapong J, Madhyastha H, Madhyastha R, Nurrahmah QI, Nakajima Y, Choijookhuu N, Hishikawa Y, Maruyama M. Arsenic trioxide induces ROS activity and DNA damage,leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway. Environ Sci Pollut Res Int. 2017 Feb;24(6):5316-5325. doi:10.1007/s11356-016-8215-7.

Tajima T, Sekimoto T, Yamaguchi N, Taniguchi N, Kurogi S, Maruyama M, Chosa E. Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage. BMC Musculoskelet Disord. 2017 Nov 14;18(1):449. doi: 10.1186/s12891-017-1815-7.

Yamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y, Pengjam Y, Nakajima Y, Maruyama M. Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. J Toxicol Sci. 2016 Feb;41(1):105-13. doi: 10.2131/jts.41.105.

Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y, Maruyama M. NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells. Phytomedicine. 2016 Apr 15;23(4):417-28. doi: 10.1016/j.phymed.2016.01.006.

Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y, Maruyama M. Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling. Biomolecules & Therapeutics. 2016 Mar 1;24(2):123-31. doi: 10.4062/biomolther.2015.106.