業績

2024年の実績

Akashi J, Iwataki M, Nabeshima Y, Onoue T, Hayashi A, Tanaga T, Nishino S, Kimura T, Yano M, Watanabe N, Tsuda Y, Araki M, Shibata Y, Nishimura Y, Otsuji Y, Kataoka M. Potential Effects of Mild Atrial Secondary Mitral Regurgitation in Patients With Isolated Atrial Fibrillation. Circ Cardiovasc Imaging. 2024 Mar;17(3):e016239. doi: 10.1161/CIRCIMAGING.123.016239.
Amano M, Izumi C, Toki M, Yanagi Y, Hayashida A, Kawamoto T, Hiraoka A, Fukushima S, Sakaguchi T, Watanabe N, Yoshida K. Mitral Valve Early Systolic Billowing Induces Following Annular Expansion and Leaflet Augmentation in Barlow’s Disease: Sequential Analysis using Three-dimensional Echocardiography. Eur Heart J Cardiovasc Imaging. 2024 Jan 30:jeae031. doi: 10.1093/ehjci/jeae031.
Watanabe N, Ashikaga K. Mitral regurgitation improvement after successful atrial fibrillation ablation by using a 3D mapping system. Ann Cardiothorac Surg. 2024 Jan 30;13(1):99-101. doi: 10.21037/acs-2023-afm-0079.

2023年の実績

渡邉 望. 心エコー図による評価 臨牀と研究 100(9) 8-14 2023.9
Koiwaya H, Watanabe N, Kuriyama N, Shibata Y. Direct Oral Anticoagulants Would Be Best Choice for Atrial Fibrillation Patients After Coronary Stenting: Retrospective Study in a Japanese Population. Kurume Med J. 2023 Jul 3;68(2):97-106. doi: 10.2739/kurumemedj.MS682015.
Furugen M, Watanabe N, Kimura T, Yano M, Shibata Y. Leaflet tear or what? A challenging echocardiographic diagnosis after percutaneous mitral valve edge-to-edge repair. J Echocardiogr. 2023 Mar;21(1):61-62. doi: 10.1007/s12574-021-00550-9.
Madhyastha H, Madhyastha R, Chakraborty E, Banerjee K, Shah K, Nakajima Y, Chauhan NS, Sudhakaran SL, Ohe K, Muthukaliannan GK, Gopalakrishnan AV, Maruyama M, Watanabe N. Fluro-Protein C-Phycocyanin Docked Silver Nanocomposite Accelerates Cell Migration through NFkB Signaling Pathway. Int. J. Mol. Sci. 2023 Feb 6;24(4):3184. doi: 10.3390/ijms24043184.
Kagiyama N, Maekawara S, Izumi Y, Watanabe N, Otsuji Y, Yoshida K. Dynamic Nature of the Mitral Valve Morphology: Consideration of the Normal Ranges. J Am Soc Echocardiogr. 2023 Jan;36(1):125-126. doi: 10.1016/j.echo.2022.09.005.
Gangadaran P, Madhyastha H, Madhyastha R, Rajendran RL, Nakajima Y, Watanabe N, Velikkakath AKG, Hong CM, Gopi RV, Muthukalianan GK, Valsala Gopalakrishnan A, Jeyaraman M, Ahn BC. The emerging role of exosomes in innate immunity, diagnosis and therapy. Front Immunol. 2023 Jan 16;13:1085057. doi: 10.3389/fimmu.2022.1085057.

2022年の実績

Sharma S, Madhyastha H, Kirwale SS, Sakai K, Katakia YT, Majumder S, Roy A. Carbohydr Polym. Dual antibacterial and anti-inflammatory efficacy of a chitosan-chondroitin sulfate-based in-situ forming wound dressing. 2022 Dec 15;298:120126. doi: 10.1016/j.carbpol.2022.120126.
Yoshioka G, Tanaka A, Watanabe N, Nishihira K, Natsuaki M, Kawaguchi A, Shibata Y, Node K. Prognostic impact of incident left ventricular systolic dysfunction after myocardial infarction. Front Cardiovasc Med. 2022 Sep 29;9:1009691. doi: 10.3389/fcvm.2022.1009691.
Honda Y, Watanabe N, Nishino S, Shibata Y. Dynamic changes in the three-dimensional mitral complex geometry in a case of takotsubo cardiomyopathy with transient systolic anterior movement of the mitral valve. J Cardiol Cases. 2022 Jun 4;26(3):190-193. doi: 10.1016/j.jccase.2022.04.017.
Gi T, Nishino S, Yamashita A, Watanabe N, Shibata Y, Asada Y. Multiple asymptomatic coronary plaque ruptures and fissures in acute myocardial infarction. Pathol Int. 2022 Jun;72(6):355-357. doi: 10.1111/pin.13229.
Miyoshi M, Watanabe N, Fukuda T, Nishino S, Kimura T, Furugen M, Ashikaga K, Takahashi N, Shibata Y. Left atrial appendage orifice dimensions in Japanese atrial fibrillation population measured by multiplane transesophageal echocardiography. J Echocardiogr. 2022 May 19. doi: 10.1007/s12574-022-00575-8.
渡邉 望. 機能性僧帽弁逆流の診断と治療:弁膜症治療ガイドライン2020改訂を踏まえて 宮崎県医師会医学会誌 46(1) 1-7 2022
Bethasiwi Purbasari, Radha Madhyastha, Harishkumar Madhyastha, Queen Intan Nurrahmah, Masugi Maruyama, Yuichi Nakajima, Hiroaki Kataoka, Nozomi Watanabe. Retinoic acid attenuates nuclear factor kappaB mediated induction of NLRP3 inflammasome. Pharmacol Rep. 2022 Feb;74(1):189-203. doi: 10.1007/s43440-021-00321-4.

2021年の実績

Shinomiya H, Asano Y, Watanabe N, Tsuruda T, Arimura T, Miyashita Y, Miyasaka Y, Mashimo T, Takuwa A, Motooka D, Okuzaki D, Matsuoka K, Tsukamoto O, Hakui H, Yamada N, Lee JK, Kioka H, Kitakaze M, Takashima S, Sakata Y, Asano Y.et.al. Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy. Journal: FASEB J. 2021 Nov;35(11): e21994. doi: 10.1096/fj.202100800R.
Harishkumar M, Radha M, Yuichi N, Muthukalianan GK, Kaoru O, Shiomori K, Sakai K, Nozomi W. Designer Exosomes: Smart Nano-Communication Tools for Translational Medicine. Bioengineering (Basel, Switzerland). 2021 Oct 26;8(11):158. doi: 10.3390/bioengineering811015
Sharma S, Madhyastha H, Laxmi Swetha K, Maravajjala K.S, Singh A, Madhyastha R, Nakajima Y, Roy A. Development of an in-situ forming, self-healing scaffold for dermal wound healing: in-vitro and in-vivo studies. Mater Sci Eng C Mater Biol Appl. 2021 Sep;128:112263. doi: 10.1016/j.msec.2021.112263.
Banerjee K, Chatterjee M, Sandur V R, Nachimuthu R, Madhyastha H, Thiagarajan P. Azadirachta indica A. Juss (Neem) oil topical formulation with liquid crystals ensconcing depot water for anti-inflammatory, wound healing and anti-methicillin resistant Staphylococcus aureus activities. Journal of Drug Delivery Science and Technology.2021 May 64:102563, doi: 10.1016/j.jddst.2021.102563
Suresh K, Bankapur A, Chidangil S, Madhyastha H, Sa-Kai K, George S.D. A broadband optical pH sensor using upconversion luminescence. Journal of Materials Chemistry C.2021, doi: 10.1039/d1tc00792k
Asmi N, Ahmad A, Natsir H, Massi M.N. Karim H, Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M. Proportion of anticancer activity of protein and protein hydrolysate from epiphytic bacteria. Rasayan Journal of Chemistry.2021,14(3).1594-1599. doi: 10.31788/RJC.2021.1436313
Hidehiko Kikuchi, Kaori Harata, Sumiko Akiyoshi, Harishkumar Madhyastha, Futoshi Kuribayashi. 3′, 4′-Dihydroxyflavone enhances all-trans retinoic acid-induced superoxide-generating activity through up-regulating transcription of gp91-phox in human monoblastic U937 cells, as opposed to flavone and other. Fundamental Toxicological Sciences. 2021,8(2):53-59. doi: 10.2131/fts.8.53
Makoto Furugen, Nozomi Watanabe, Shun Nishino, Toshiyuki Kimura, Keiichi Ashikaga, Nehiro Kuriyama, Yoshisato Shibata. Impact of osteogenic activity on degenerative aortic valve disease in patients with osteoporotic hip fracture. Journal of Cardiology. 2021 Nov;78(5):423-430. doi: 10.1016/j.jjcc.2021.05.014.
Kaushita Banerjee, Radha Madhyastha, Yuichi Nakajima, Masugi Maruyama, Harishkumar Madhyastha. Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects. International Journal of Molecular Sciences. 2021 Apr 29;22(9):4748. doi: 10.3390/ijms22094748.
Koiwaya H, Watanabe N, Nishihira K, Goriki Y, Shibata Y. ST-Elevation Myocardial Infarction With Cardiogenic Shock and Severe Acute Ischemic Mitral Regurgitation Rescued by Primary Coronary Intervention Under Hemodynamic Support With Impella. Circulation Reports. 2021 Apr 10;3(5):304-305. doi: 10.1253/circrep.CR-20-0131.
Matsuura H, Watanabe N, Shibata Y, Asada Y. Combination of echocardiography and emergency endomyocardial biopsy for suspected myocarditis in the cardiovascular emergency medical care. J Echocardiogr. 2021 Jun;19(2):86-94. doi: 10.1007/s12574-021-00521-0.
Jayasindu Mathiyazhagan, Ramamoorthy Siva, Rama Jayaraj, Harishkumar Madhyastha 3, Gothandam Kodiveri Muthukaliannan. Preventive Effect of Combined Zingiber officinale and Terminalia chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition. Nutr Cancer. 2021 Apr 74(2);1-10. doi: 10.1080/01635581.2021.1903948.
Queen Intan Nurrahmah, Radha Madhyastha, Harishkumar Madhyastha, Bethasiwi Purbasari, Masugi Maruyama, Yuichi Nakajima. Retinoic acid abrogates LPS-induced inflammatory response via negative regulation of NF-kappa B/miR-21 signaling. Immunopharmacol Immunotoxicol. 2021 Jun;43(3):299-308. doi: 10.1080/08923973.2021.1902348.
Vishal Panchariya, Vishal Bhati, Harishkumar Madhyastha, Radha Madhyastha, Jagdish Prasad, Priyal Sharma, Paras Sharma, Harish, Mahesh Kumar Saini, Vishnu D Rajput, Yuichi Nakajima, S L Kothari, Vinod Singh Gour. Chromatic intervention and biocompatibility assay for biosurfactant derived from Balanites aegyptiaca (L.) Del. Sci Rep. 2021 Feb 18;11(1):4186. doi: 10.1038/s41598-021-83573-7.
Kaviyarasi Renu, Rituraj Chakraborty, Haritha Myakala, Rajeshwari Koti, Ademola C Famurewa, Harishkumar Madhyastha, Balachandar Vellingiri, Alex George, Abilash Valsala Gopalakrishnan. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) – induced hepatotoxicity – A review. Chemosphere. 2021 May; 271:129735. doi: 10.1016/j.chemosphere.2021.129735.
Radha Madhyastha, Harishkumar Madhyastha, Queen Intan Nurrahmah, Bethasiwi Purbasari, Masugi Maruyama & Yuichi Nakajima. MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles. Inflammation. Jan. 2021 Aug;44(4):1274-1287. doi: 10.1007/s10753-021-01415-0.
R Ranjitha, K N Meghana, V G Dileep Kumar, Aarti S Bhatt, B K Jayanna, C R Ravikumar, Mysore Sridhar Santosh, H Madhyastha and K Sakai. Rapid photocatalytic degradation of cationic organic dyes using Li-doped Ni/NiO nanocomposites and their electrochemical performance. New J. Chem.,2021,45,796. doi:10.1039/d0nj05268j
Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, and Inderchand Manjubala. Characterization and In Vitro Evaluations of Injectable Calcium Phosphate Cement Doped with Magnesium and Strontium. ACS Omega. 2021 Jan 20;6(4):2477-2486. doi: 10.1021/acsomega.0c03927.
Saravanan Krishnan, Deepthy Jayakumar, Harishkumar Madhyastha & Anju Chadha. The Complexity of Microbial Metal Nanoparticle Synthesis: A Study of Candida parapsilosis ATCC 7330 mediated Gold Nanoparticles Formation. Bio Nano Science. Jan. 2021. 11: 336–344. doi: 10.1007/s12668-021-00825-6
Hidehiko Kikuchi, Kaori Harata, Harishkumar Madhyastha, Futoshi Kuribayashi. Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells. Biochemistry and Biophysics Reports 2021 Jan 6;25:100891. doi: 10.1016/j.bbrep.2020.100891.
Jayasindu Mathiyazhagan, Ramamoorthy Siva, Rama Jayaraj, Harishkumar Madhyastha 3, Gothandam Kodiveri Muthukaliannan. Preventive Effect of Combined Zingiber officinale and Terminalia chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition. Nutr Cancer. 2021 Apr 6;1-10. doi: 10.1080/01635581.2021.1903948.
Queen Intan Nurrahmah, Radha Madhyastha, Harishkumar Madhyastha, Bethasiwi Purbasari, Masugi Maruyama, Yuichi Nakajima. Retinoic acid abrogates LPS-induced inflammatory response via negative regulation of NF-kappa B/miR-21 signaling. Immunopharmacol Immunotoxicol. 2021 Mar 24;1-10. doi: 10.1080/08923973.2021.1902348.
Vishal Panchariya, Vishal Bhati, Harishkumar Madhyastha, Radha Madhyastha, Jagdish Prasad, Priyal Sharma, Paras Sharma, Harish, Mahesh Kumar Saini, Vishnu D Rajput, Yuichi Nakajima, S L Kothari, Vinod Singh Gour. Chromatic intervention and biocompatibility assay for biosurfactant derived from Balanites aegyptiaca (L.) Del. Sci Rep. 2021 Feb 18;11(1):4186. doi: 10.1038/s41598-021-83573-7.
Kaviyarasi Renu, Rituraj Chakraborty, Haritha Myakala, Rajeshwari Koti, Ademola C Famurewa, Harishkumar Madhyastha, Balachandar Vellingiri, Alex George, Abilash Valsala Gopalakrishnan. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) – induced hepatotoxicity – A review. Chemosphere. 2021 May; 271:129735. doi: 10.1016/j.chemosphere.2021.129735.
Radha Madhyastha, Harishkumar Madhyastha, Queen Intan Nurrahmah, Bethasiwi Purbasari, Masugi Maruyama & Yuichi Nakajima. MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles. Inflammation. Jan. 2021. 44: 1274–1287. doi: 10.1007/s10753-021-01415-0
Hidehiko Kikuchi, Kaori Harata, Harishkumar Madhyastha, Futoshi Kuribayashi. Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells. Biochemistry and Biophysics Reports Volume 25, March 2021, 100891 doi:10.1016/j.bbrep.2020.100891

2020年の実績

Aya Shibata, Kaori Harata, Yuko Moriguchi, Risako Kanegawa, Ayaka Nagahira, Misaki Shigematsu, Yuri Takamura, Haruno Watanabe, Takefumi Sagara, Harishkumar Madhyastha and Hidehiko Kikuchi. Production and evaluation of the authentic milk bread using a lactose-utilizing yeast, Kluyveromyces marxianus. Current Topics in Biotechnology. Vol. 11, 2020
Meghana Matur, Harishkumar Madhyastha, T S Shruthi, Radha Madhyastha, S P Srinivas, P N Navya, Hemant Kumar Daima. Engineering bioactive surfaces on nanoparticles and their biological interactions. Sci Rep. 2020 Nov 12;10(1):19713. doi: 10.1038/s41598-020-75465-z.
Akhela Umapathi, Navya PN, Harishkumar Madhyastha, Mandeep Singh, Radha Madhyastha, Masugi Maruyama, Hemant Kumar Daima. Curcumin and isonicotinic acid hydrazide functionalized gold nanoparticles for selective anticancer action. Colloids and Surfaces A. Volume 607, 20 December 2020, 125484. doi:10.1016/j.colsurfa.2020.125484
Harishkumar Madhyastha, Radha Madhyastha, Abhishek Thakur, Sakai Kentaro, Abhimanyu Dev, Sneha Singh, Bistivalli Chandrashekharappa R, Hemanth Kumar, Orlando Acevedo, Yuichi Nakajima, Hemant Kumar Daima, Akhela Aradhya, Navya Nagaraj P, Masugi Maruyama. c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism. Colloids Surf B Biointerfaces. 2020 Oct; 194:111211. doi: 10.1016/j.colsurfb.2020.111211.
Akshay Bhatt, Kentaro Sakai, Radha Madhyastha, Masugi Murayama, Harishkumar Madhyastha, Subha Narayan Rath. Biosynthesis and characterization of nano magnetic hydroxyapatite (nMHAp): An accelerated approach using simulated body fluid for biomedical applications. Ceramics International on December 01, 2020. doi:10.1016/j.ceramint.2020.07.285
Madhyastha H, Halder S, Queen Intan N, Madhyastha R, Mohanapriya A, Sudhakaran R, Sajitha L. S, Banerjee K, Bethasiwi P, Daima H, Navya P N, Maruyama M and Nakajima Y. Surface refined AuQuercetin nanoconjugate stimulates dermal cell migration: possible implication in wound healing. RSC Advances 10(62):37683-37694. doi: 10.1039/d0ra06690g
Hidehiko Kikuchi, Kaori Harata, Chikage Kawai, Harishkumar Madhyastha, Akira Yamauchi, Futoshi Kuribayashi. Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils. Fundamental Toxicological Scie .7 (2020) 4. doi: 10.2131/fts.7.201
Kaviyarasi Renu, Anusha Saravanan, Anushree Elangovan, Sineka Ramesh, Sivakumar Annamalai, Arunraj Namachivayam, Praveena Abel, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vellingiri Balachandar, Abilash Valsala Gopalakrishnan. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity.p Life Sci. 2020 Nov 1;260:118438. doi: 10.1016/j.lfs.2020.118438.
Kaushita Banerjee, Harishkumar Madhyastha, Rajendra Sandur V, Manikandanath NT, Thiagarajan N, Padma Thiagarajan. Anti-inflammatory and wound healing potential of a clove oil emulsion. Colloids and Surfaces B: Biointerfaces Volume 193, September 2020, 111102. doi: 10.1016/j.colsurfb.2020.111102

2019年の実績

H. Kikuchi,H. Mimuro, H.Madhyastha and F. Kuribayashi. Chalcone skeleton promots transcription of gp91-phox gene but inhibits expression of gp91-phox protein and hydroxyl groups in hydroxychalcones participates in the stable expression of gp-91-Phox protein. Microbiol Immunol. 2019 Oct;63(10):438-443. doi: 10.1111/1348-0421.12732.
A Umapathi., N P Nagaraju, H Madhyastha, D Jain, S P Srinivas, V M Rotello, H K Daima. Highly efficient and selective antimicrobial isonicotinnylhydrazide-coated polyoxometalate-functionalized silver nanoparticles. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110522. doi: 10.1016/j.colsurfb.2019.110522.
R Ranjitha, A.S.Bhat, C R Ravikumar, M S Santhosh, B K Jayanna, H.P Nagaswarupa, K Sakai and H Madhyastha. Electroactive Li incorporated cobalt oxide nanostructures for photocatalytic applications. Mater. Res. Express 6 1150d6 Published 1 November 2019
S. Akiyoshi, H.Kikuchi, F. Kuribayashi, H.Madhyastha and H.Minami. Sulforaphane displays the growth inhibition cytotoxicity and enhancement of retinoic acid induced superoxide generating activity in human monoblastic U937 cells. Fundamental Toxicological Sciences. DOI:10.2131/fts.6.319
Navya PN, Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M, Srinivas SP,Jain D, Amin MH, Bhargava SK, Daima HK. Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide.Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:286-294. 10.1016/j.msec.2018.11.024
Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M. The pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin. J Nat Med. 2019 Jan;73(1):59-66. doi: 10.1007/s11418-018-1237-3.
Sharma P, Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M, Verma KS, Verma S, Prasad J, Kothari SL, Gour VS. An appraisal of cuticular wax of Calotropis procera (Ait.) R. Br.: Extraction, chemical composition, biosafety and application. J Hazard Mater. 2019 Apr 15;368:397-403. doi:10.1016/j.jhazmat.2019.01.067.
Madhyastha H, Madhyastha R, Nakajima Y, Daima HK, Navya PN, Maruyama M. An opinion on nanomedicine and toxico-cellular crosstalk: Considerations and Caveats. ScienceDirect. doi:10:p100-105. 2019
Queen Intan Nurrahmah, Radha Madhyastha, Hrishkumar Madhyastha, Yuichi Nakajima, Masugi Maruyama. Nuclear factor-kappa B and JNK mediate macrophage polarization shift induced by C-phycocyanin. Indian Journal of Experimental Biology. 57: p381-389. 2019
Khin Phyu Phyu, Phyo Wai Zin, Myo Nanda Aung, Mya Mar Lar, Yoshitaka Hishikawa, Masugi Maruyama, Hiroshi Yokota, Hitoshi Mochizuki, Kyaw Zin Thant, Khin Thet Wai, Yasunori Yano. Contamination of arsenic in drinking water in Ayeyarwady delta region, MYANMAR. World journal of Pharmaceutical and Life Sciences WJPLS. 5(8): 42-48. 2019
Mochizuki H, Phyu KP, Aung MN, Zin PW, Yano Y, Myint MZ, Thit WM, Yamamoto Y, Hishikawa Y, Thant KZ, Maruyama M, Kuroda Y. Peripheral neuropathy induced by drinking water contaminated with low-dose arsenic in Myanmar. Environ Health Prev Med. 2019 Apr 23;24(1):23. doi: 10.1186/s12199-019-0781-0.

2018年の実績

Madhyastha H, Madhyastha R, Nakajima Y, Maruyama M. Deciphering the molecular events during arsenic induced transcription signal cascade activation in cellular milieu. Biometals. 2018 Feb;31(1):7-15. doi: 10.1007/s10534-017-0065-3.
Medha M. Ugru, Sanjana Sheshadri, Devendra Jain, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, P.N. Navya, Hemant Kumar Daima. Insight into the composition and surface corona reliant biological behaviour of quercetin engineered nanoparticles. Colloids and Surfaces A. 548:1-9. 2018 doi: 10.1016/j.colsurfa.2018.03.055
Ahmad A, Agus R, Massi MN, Natzir R, Madhyastha R, Madhyastha HK, Maruyama M. Cloning and expression of MPT83 gene from Mycobacterium tuberculosis in E. coli BL21 as vaccine candidate of tuberculosis: A preliminary study. J Genet Eng Biotechnol. 2018 Dec;16(2):335-340. doi: 10.1016/j.jgeb.2018.04.001.
Renu K, Madhyastha H, Madhyastha R, Maruyama M, Arunachlam S, V G A. Role of arsenic exposure in adipose tissue dysfunction and its possible implication in diabetes pathophysiology. Toxicol Lett. 2018 Mar 1;284:86-95. doi:10.1016/j.toxlet.
Renu K, Madhyastha H, Madhyastha R, Maruyama M, Vinayagam S, Valsala Gopalakrishnan A. Review on molecular and biochemical insights of arsenic-mediated male reproductive toxicity. Life Sci. 2018 Nov 1;212:37-58. doi:10.1016/j.lfs.2018.09.045.

2017年以前の実績

Chayapong J, Madhyastha H, Madhyastha R, Nurrahmah QI, Nakajima Y, Choijookhuu N, Hishikawa Y, Maruyama M. Arsenic trioxide induces ROS activity and DNA damage,leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway. Environ Sci Pollut Res Int. 2017 Feb;24(6):5316-5325. doi:10.1007/s11356-016-8215-7.
Tajima T, Sekimoto T, Yamaguchi N, Taniguchi N, Kurogi S, Maruyama M, Chosa E. Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage. BMC Musculoskelet Disord. 2017 Nov 14;18(1):449. doi: 10.1186/s12891-017-1815-7.
Yamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y, Pengjam Y, Nakajima Y, Maruyama M. Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. J Toxicol Sci. 2016 Feb;41(1):105-13. doi: 10.2131/jts.41.105.
Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y, Maruyama M. NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells. Phytomedicine. 2016 Apr 15;23(4):417-28. doi: 10.1016/j.phymed.2016.01.006.
Pengjam Y, Madhyastha H, Madhyastha R, Yamaguchi Y, Nakajima Y, Maruyama M. Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling. Biomolecules & Therapeutics. 2016 Mar 1;24(2):123-31. doi: 10.4062/biomolther.2015.106.