Our laboratory focuses on the pathogenesis of thrombosis and atherosclerosis.

Thrombosis is the formation of a blood clot (thrombus). Thrombus may form in any part of the cardiovascular system, including arteries, veins the heart and the microcirculation. Arterial thrombi usually develop on the disrupted atherosclerotic lesions (atherothrombosis), causing myocardial infarction and ischemic stroke, etc. Venous thrombi usually occur in the lower limbs, which is a major cause of pulmonary thromboembolism. Thrombi are composed of fibrin and blood cells. However the mechanisms of thrombus formation and propagation remain unclear, because many factors, such as vessel wall constituents, local hemorheology, systemic thrombogenicity, also immune and inflammatory reactions, are involved in the process. We have studied the issue from the viewpoint of human and experimental pathology, and have elucidated the crucial role of vascular tissue factor and blood flow alteration.

Staff information
Atsushi Yamashita, MD, PhD
Associate Professor:
Yuichiro Sato, MD, PhD (Division of Diagnostic Pathology, University Hospital)
Assistant Professor:
Murasaki Aman, MD, PhD
Sayaka Moriguchi, MD, PhD
Kazunari Maekawa, MD, PhD
Toshihiro Gi, MD, PhD
Clinical Fellow:
Eriko Nakamura, MD, PhD
Nobuyuki Oguri, MD
Mayu Kurogi, MD

Contact information
Division of Pathophysiology, Department of Pathology
Faculty of Medicine, University of Miyazaki

5200 Kihara, Kiyotake, Miyazaki, Miyazaki, Japan

TEL: +81-985-85-2810
Fax: +81-985-85-7614