Laboratory staff

Contact

Professor
Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Phone: +81-985-85-9815, Fax: +81-985-85-989

Summary

Research Projects

Lab Techniques

1.
Isolation and culture of immune cells from organ and tissue.
2.
Assay for immune cell function in vivo and in vitro.
3.
Detection of the expression of gene and protein (e.g., PCR, Southern blotting, Western blotting, ELISA).
4.
Generation of gene-modified protein, cells and mouse by molecular biology techs (e.g., mutagenesis, retroviral gene transduction, gene knock-out/knock-in) .
5.
Flow cytometry and cell sorting (immunolabeling [FACS and MACS]).
6.
Histological observation (e.g., immunostaining [confocal microscopy]).
7.
Assay for immunopathogenesis in murine models.

Publication

2021
Nishikawa Y., Fukaya, T., Fukui, T., Uto, T., Takagi, H., Nasu, J., Miyanaga, N., Riethmacher, D., Choijookhuu, N., Hishikawa, Y., Amano, M., and Sato, K. Congenital deficiency of conventional dendritic cells promotes the development of atopic dermatitis-like inflammation. Front. Immunol., 12:712676, 2021
Mitoma, S., El-khaiat, H.M.K., Uto, T., Sato, K., Sekiguchi, S., and Norimine, J. Characterization of bovine IL-2 stably expressed in HEK-293 cells. J. Vet. Med. Sci., 83:134-141, 2021
2020
Miyanaga, N., Takagi, H., Uto, T., Fukaya, T., Nasu, J., Fukui, T., Nishikawa, Y., Sparwasser, T., Choijookhuu, N., Hishikawa, Y., Nakamura, T., Tono, T., and Sato, K. Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Commun. Biol., 3:742, 2020
Konishi, H., Okamoto, T., Hara, Y., Komine, O., Tamada, H., Maeda, M., Osako, F., Kobayashi, M.., Nishiyama, A., Kataoka, Y., Takai, T., Udagawa, N., Jung, S., Ozato, K., Tamura, T., Tsuda, M., Yamanaka, K., Ogi, T., Sato. K., and Kiyama, H. Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction. EMBO J., 39:e104464, 2020
Mai, N.N.H., Yamaguchi, Y., Choijookhuu, N., Matsumoto, J., Nanashima, A., Takagi, H., Sato, K., Tuan, L.Q., and Hishikawa, Y. Photodynamic therapy using a novel phosphorus tetraphenylporphyrin induces an anticancer effect via Bax/Bcl-xL-related mitochondrial apoptosis in biliary cancer cells. Acta Histochem. Cytochem., 53:61-72, 2020
Nasu, J., Uto, T., Fukaya, T., Takagi, H., Fukui, T., Miyanaga, N., Nishikawa, Y., Yamasaki, S., Yamashita, Y., and Sato, K. Pivotal role of the carbohydrate recognition domain in self-interaction of CLEC4A to elicit the ITIM-mediated inhibitory function in murine conventional dendritic cells in vitro. Int. Immunol., 32:673-682, 2020
Fukui, T., Fukaya, T., Uto, T., Takagi, H., Nasu, J., Miyanaga, N., Nishikawa, Y., Koseki, H., Choijookhuu, N., Hishikawa, Y., Yamashita, Y., and Sato, K. Pivotal role of CD103 in the development of psoriasiform dermatitis. Sci. Rep., 10:8371, 2020
Kato, H. Okabe, K., Miyake, M., Hattori, K., Fukaya, T., Tanimoto, K., Beini, S., Mizuguchi, M., Torii, S., Arakawa, S., Ono, M., Saito, Y., Suguyama, T., Funatsu, T., Sato, K., Shimizu, S., Oyadomari, S., Ichijo, H., Kadowaki, H., and Nishitoh, H. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life Science Alliance, 3:e201900576, 2020
2019
Katahira, Y., Higuchi, H., Matsushita, H., Yahata, T., Yamamoto, Y., Koike, R., Ando, K., Sato, K., Imadome, K.I., and Kotani, A. Increased granulopoiesis in the bone marrow following Epstein-Barr virus infection. Sci. Rep., 9:13445, 2019
Koda, Y., Nakamoto, N., Chu, P.S., Ugamura, A., Mikami, Y., Teratani, T., Tsujikawa, H., Shiba, S., Taniki, N., Sujino, T., Miyamoto, K., Suzuki, T., Yamaguchi, A., Morikawa, R., Sato, K., Sakamoto, M., Yoshimoto, T., and Kanai, T. Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35. J. Clin. Invest., 129:3201-3213, 2019
Saitoh, S.I., Saitoh, Y.M., Kontani, K., Sato, K., and Miyake, K. ADP-ribosylation factor-like 8b is required forthe development of mouse models of systemic lupus erythematosus. Int. Immunol., 31:225-237, 2019
Kyaw, M.T.H., Yamaguchi, Y., Choijookhuu, N., Yano, K., Takagi, H., Takahashi, N., Oo, P.S., Sato, K., and Hishikawa, Y. The HDAC inhibitor, SAHA, combined with cisplatin synergistically induces apoptosis in alpha-fetoprotein-producing hepatoid adenocarcinoma cells. Acta Histochem. Cytochem., 52:1-8, 2019
Kawaguchi, M., Yamamoto, K., Takeda, N., Fukushima, T., Yamashita, F., Sato, K., Kitamura, K., Hippo, Y. James W. Janetka, J.W., and Kataoka, H. Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the intestine. Commun. Biol., 2:11, 2019
2018
Fukaya, T., Fukui, T., Uto, T., Takagi, H., Nasu, J., Miyanaga, N., Arimura, K., Nakamura, T., Koseki, H., Choijookhuu, N., Hishikawa, Y., and Sato, K. Pivotal role of IL-22 binding protein in the epithelial autoregulation of interleukin-22 signaling in the control of skin inflammation. Frontiers. Immunol., 9:1418, 2018
Uto, T., Takagi, H., Fukaya, T., Nasu, J., Fukui, T., Miyanaga, N., Arimura, K., Nakamura, T., Choijookhuu, N., Hishikawa, Y., Yamashita, Y., and Sato, K. Critical role of plasmacytoid dendritic cells in induction of oral tolerance. J. Allergy Clin. Immunol., 141:2156-2147, 2018.
Ali, M.N., Choijookhuu, N., Takagi, H., Srisowanna, N., Huynh, M.N.N., Yamaguchi, Y., Oo, P.S., Kyaw, M.T.H., Sato, K., Yamaguchi, R., and Hishikawa.Y. The HDAC inhibitor, SAHA, prevents colonic inflammation by suppressing pro-inflammatory cytokines and chemokines in DSS-induced colitis. Acta Histochem. Cytochem., 51:33-40, 2018
Lee, D., Taniguchi, N., Sato, K., Choijookhuu, N., Hishikawa, Y., Kataoka, H., Morinaga, H., Lotz, M., and Chosa, E. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles. Sci. Rep., 8:9601, 2018
2017
Arimura, K., Takagi, H., Uto, T., Fukaya, T., Nakamura, T., Choijookhuu, N., Hishikawa, Y., Yamashita, Y., and Sato, K. Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation. Mucosal Immunol., 10:957-970, 2017
Nakamura, T., Fukaya, T., Uto, T., Takagi, H., Arimura, K., Tono, T., and Sato, K. Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis. Biochem. Biophys. Rep., 9:29-35, 2017
Konishi, H., Kobayashi, M., Kunisawa, T., Imai, K., Sayo, A., Malissen, B., Crocker, P.R., Sato, K., and Kiyama, H. Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes. GLIA, 65:1927-1943, 2017.
Saitoh, S.I., Abe, F., Kanno, A., Tanimura, N., Mori Saitoh, Y., Fukui, R., Shibata, T., Sato, K., Ichinohe, T., Hayashi, M., Kubota, K., Kozuka-Hata, H., Oyama, M., Kikko, Y., Katada, T., Kontani, K., and Miyake, K. TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat. Commun., 8:1592, 2017
2016
Takagi, H., Arimura, K., Uto, T., Fukaya, T., Nakamura, T., Choijookhuu, N., Hishikawa, Y., and Sato, K. Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation. Sci. Rep., 6:24477, 2016
Uto, T., Fukaya, T., Takagi, H., Arimura, K., Nakamura, T., Kojima, N., Malissen, B.,and Sato, K. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat. Commun., 7:11273, 2016
Matsuoka, Y., Takagi, H., Yamatani, M., Kuroda, Y., Sato, K., and Kojima N. Requirement of TLR4 signaling for the induction of a Th1 immune response elicited by oligomannose-coated liposomes. Immunol. Lett., 178:61-67, 2016
2013
Yamazaki, C., Sugiyama, M., Ohta, T., Hemmi, H., Hamada, E., Sasaki, I., Fukuda, Y., Yano, T., Nobuoka, M., Hirashima, T., Iizuka, A., Sato, K., Tanaka, T., Hoshino, K., and Kaisho, T. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J. Immunol., 190:6071-6082, 2013
2012
Sasaki, I., Hoshino, K., Sugiyama, Y., Yamazaki, C., Yano, T., Iizuka, A., Hemmi, H., Tanaka, T., Saito, M., Sugiyama, M., Fukuda, Y., Ohta, T., Sato, K., Ainai, A., Suzuki, T., Hasegawa, H., Toyama-Sorimachi, N., Kohara, H., Nagasawa, T., and Kaisho, T. Spi-B is critical for plasmacytoid dendritic cell function and development. Blood, 120:4733-4743, 2012
Kagiyama, Y., Kitaura, J., Togami, K., Uchida, T., Inoue, D., Matsukawa, T., Izawa, K., Kawabata, K.C., Komeno, Y., Oki, T., Nakahara, F., Sato, K., Aburatani, H., and Kitamura, T. Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Int. J. Hematol., 96:638-648, 2012
Fukaya, T., Murakami, R., Takagi, H., Sato, K., Sato, Y., Otsuka, H., Ohno, M.,Hijikata, A., Ohara, O., Hikida, M., Malissen, B., and Sato, K. Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T cell immunity and homeostasis in vivo. Proc. Natl. Acad. Sci. USA, 109:11288-11293, 2012
2011
Takagi, H., Fukaya, T., Eizumi, K., Sato, Y., Sato, K., Shibazaki, A., Otsuka, H., Hijikata, A., Watanabe, T., Ohara, O., Kaisho, T., Malissen, B., and Sato, K. Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity, 35:958-971, 2011
2010
Fukaya, T., Takagi, H., Sato, Y., Sato, K., Eizumi, K., Taya, H., Shin, T., Chen, L., Dong, C., Azuma, M., Yagita, H., Malissen, B., and Sato, K. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood, 116:2266-2276, 2010
2009
Sato, K., Eizumi, K., Fukaya, T., Fujita, S., Sato, Y., Takagi, H., Yamamoto, M., Yamashita, N., Hijikata, A., Kitamura, H., Ohara, O., Yamasaki, S., Saito, T., and Sato, K. Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood, 113:4780-4789, 2009
Candolfi, M., Yagiz, K., Foulad, D., Alzadeh, G.E., Tesarfreund, M., Muhammad, A.K., Puntel, M., Kroeger, K.M., Liu, C., Lee, S., Curtin, J.F., King, G.D., Lerner,J., Sato, K., Mineharu, Y., Xiong, W., Lowenstein, P.R., and Castro, M.G. Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. Clin. Cancer Res., 15:4401-4414, 2009
2008
Fujita, S., Yamashita, N., Ishii, Y., Sato, Y., Sato, K., Eizumi, K., Fukaya, T., Nozawa, R., Takamoto, Y., Yamashita, N., Taniguchi, M., and Sato, K. Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model. J. Allergy Clin. Immunol., 121:95-104, 2008
2007
Uto, T., Wang, X., Sato, K., Haraguchi, M., Akagi, T., Akashi, M. and Baba, M. Targeting of antigen to dendritic cells with poly(?-glutamic acid) nanoparticles induce antigen-specific humoral and cellular immunity. J. Immunol., 178:2979-2986, 2007
Matsumura, Y., Kobayashi, T., Ichiyama, K., Yoshida, R., Hashimoto, M., Takimoto, T., Tanaka, K., Chinen, T., Shichita, T., Wyss-Coray, T., Sato, K.,and Yoshimura, A. Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by SOCS3-deficient dendritic cells. J. Immunol., 179:2170-2179, 2007
Fujita, S., Sato, Y., Sato, K., Eizumi, K., Fukaya, T., Kubo, M., Yamashita, N., and Sato, K. Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ T cells. Blood, 110: 3793-3803, 2007
Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kubo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K., Ohno, H., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Sato, K., Seino, K., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng. A., Watanabe, T., Watarai, H., Yamasaki, S., and Ohara, O. Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics, 21: 2934-2941, 2007
2006
Fujita, S., Seino, K., Sato, K., Sato, Y., Eizumi, K., Yamashita, N., Taniguchi, M., and Sato, K. Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response. Blood, 107: 3656-3664, 2006
Yamashita, N., Tashimo, H., Matsuo, Y., Ishida, H., Yoshiura, K., Sato, K., Yamashita, N., Kakiuchi, T., and Ohta, K. Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model. J. Allergy Clin. Immunol., 117: 1040-1046, 2006
2005
Kawamura, M., Wang, X., Uto, T., Sato, K., Ueno, M., Akagi, T., Hiraishi, K., Matsuyama, T., Akashi, M., and Baba, M. Induction of dendritic cell-mediated immune responses against HIV-1 by antigen-capturing nanospheres in mice. J. Med. Virol., 76: 7-15, 2005
Sato, K., Nakaoka, T., Yamashita, N., Yagita, H., Kawasaki, H., Morimoto, C., Baba, M., and Matsuyama, T. TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse. J. Immunol., 174: 4025-4033, 2005
Wang, X., Uto, T., Sato, K., Ide, K., Akagi, T., Okamoto, M., Kaneko, T., Akashi, M., and Baba, M. Potent activation of antigen-specific T cells by antigen-loaded nanospheres. Immunol. Lett., 98: 123-130, 2005
Nagayoshi, R., Nagai, T., Matsushita, K., Sato, K., Sunahara, N., Matsuda, T.,Nakamura, T., Komiya, S., Onda, M., and Matsuyama, T. Effectiveness of anti-folate receptor b antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages. Arthritis Rheum., 52: 2666-2675, 2005
Yoshiura, K., Nakaoka, T., Nishishita, T., Sato, K., Yamamoto, A., Shimada, S., Saida, T., Kawakami, Y., Takahashi. T.A., Fukuda, H., Imajoh-Ohmi, S., Oyaizu, N., and Yamashita, N. Carbonic anhydrase II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy. Clin. Cancer Res., 11: 8201-8207, 2005
2004
Morishita, M., Uchimaru, K., Sato, K., Ohtsuru, A., Yamashita, S., Kanematsu, T., and Yamashita, N. Thyroglobulin-pulsed human monocyte-derived dendritic cells induce CD4+ T cell activation. Int. J. Mol. Med., 13: 33-39, 2004
2003
Sato, K., Yamashita, N., Yamashita, N., Baba, M., and Matsuyama, T. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity, 18: 367-379, 2003
Sato, K., Yamashita, N., Baba, M., and Matsuyama, T. Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood, 101: 3581-3589, 2003
Nagayama, H., Sato, K., Morishita, M., Uchimaru, K., Oyaizu, N., Inazawa, T.,Yamasaki, T.,Enomoto, M., Nakaoka, T., Nakamura, T., Maekawa, T., Yamamoto, A., Shimada, S., Saida, T., Kawakami,T., Asano, S.,Tani, K., Takahashi, T.A., and Yamashita, N. Results of phase I clinical study using autologous tumor lysate- pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2. Melanoma Res., 13: 521-530, 2003
2002
Hasebe, H., Sato, K., Yanagie, H., Takeda, Y., Nonaka, Y., Takahashi, T.A., Eriguchi, M., and Nagawa, H. Bcl-2, Bcl-xL and c-FLIP(L) potentially regulate the susceptibility of human peripheral blood monocyte-derived dendritic cells to cell death at different developmental stages. Biomed. Pharmacother., 56: 144-151, 2002
Sato, K., Kawasaki, H., Morimoto, C., Yamashita, N., and Matsuyama, T. An abortive ligand-induced activation of CC chemokine receptor (CCR)1-mediated downstream signaling event and a deficiency of CCR5 expression are associated with the hyporesponsiveness of human naive CD4+ T cells to CCL3 and CCL5. J. Immunol., 168: 6263-6272, 2002
Sato, K., Yamashita, N., and Matsuyama, T. Human peripheral blood monocyte-derived interleukin-10-induced semi-mature dendritic cells induce anergic CD4+ and CD8+ T cells via presentation of the internalized soluble antigen and cross-presentation of the phagocytosed necrotic cellular fragments. Cell. Immunol., 215: 186-194, 2002
2001
Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., and Takahashi, T.A. Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stage. Int. Immunol.,13: 167-179, 2001
Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., and Takahashi, T.A. Chemokine receptor expression and responsiveness of cord blood T cells. J. Immunol., 166: 1659-1666, 2001
2000
Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., and Takahashi, T.A. TGF-?1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors. J. Immunol., 164: 2285-2295, 2000
Suzuki, S., Tobiume, M., Kameoka, M., Sato, K., Takahashi, T.A., Mukai, T., and Ikuta, K. Exposure of normal monocyte-derived dendritic cells to human immunodeficiency virus type 1 particles leads to induction of apoptosis in co-cultured CD4+ as well as CD8+ T cells. Microbiol. Immunol., 44: 111-121, 2000
Enomoto, M., Nagayama, H., Sato, K., Xu, Y., Asano, S., and Takahashi, T.A. In vitrogeneration of dendritic cells derived from cryopreserved CD34+ cells mobilized into peripheral blood in lymphoma patients. Cytotherapy, 2: 95-104, 2000
Sato, K., Nagayama, H., Enomoto, M., Tadokoro, K., Juji, T., and Takahashi, T.A. Autocrine active-induced cell death of T cells by human peripheral blood monocyte-derived CD4+ dendritic cells. Cell. Immunol., 199: 115-125, 2000
Nagayama, H., Sato, K., Kawasaki, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., and Takahashi, T.A. IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J. Immunol., 165: 59-66, 2000
Hasebe, H., Nagayama, H., Sato, K., Enomoto, M., Takeda, Y.,Takahashi, T.A., Hasumi, K.,and Eriguchi, M. Dysfunctional regulation of the development of monocyte-derived dendritic cells in cancer patients. Biomed. Pharmacother., 54: 291-298, 2000
1999
Sato, K., Kawasaki, H., Nagayama, H., Serizawa, R., Ikeda, J., Morimoto, C., Yasunaga, K., Yamaji, N.,Tadokoro, K., Juji, T., and Takahashi, T.A. CC chemokine receptors, CCR-1 and CCR-3, are potentially involved in antigen-presenting cell function of human peripheral blood monocyte-derived dendritic cells. Blood, 93: 34-42, 1999
Wang, P.-L., Sato, K., Oido, M., Kowashi, Y., Ohura, K., Tani, H., and Kuboki, Y. Porphyromonas gingivalis protease degrades cell adhesion molecules of human
gingival fibroblasts. J. Hard Tissue Biol., 8: 1-5, 1999
Sato, K., Nagayama, H., Tadokoro, K., Juji, T., and Takahashi, T.A. Interleukin-13 is involved in functional maturation of human peripheral blood monocyte-derived dendritic cells. Exp. Hematol., 27: 326-336, 1999
Sato, K., Nagayama, H., Tadokoro, K., Juji, T., and Takahashi, T.A. Extracellular
signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-?-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J. Immunol., 162: 3865-3872, 1999
Sato, K., Nagayama, H., and Takahashi. T.A. Aberrant CD3- and CD28-mediated signaling events in cord blood T cells are associated with dysfunctional regulation of Fas ligand-mediated cytotoxicity. J. Immunol., 162: 4464-4471, 1999
1998
Sato, K. and Ochi, A. Inhibition of B cell-receptor antigen complex internalization by Fc?RIIB1 signals. Immunol. Lett., 61: 135-143, 1998
Sato, K. and Ochi, A. Superclustering of B cell receptor and Fc?RIIB1 activates Src homology 2-containing protein tyrosine phosphatase-1. J. Immunol., 161: 2716-2722, 1998
Wang, P.-L., Sato, K., Oido, M., Takeo, F., Kowashi, Y., Shinohara, M., Ohura, K., Tani, H., and Kuboki, Y. Involvement of CD14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-6 secretion. Arch. Oral Biol., 43: 687-694, 1998
Sato, K., Nagayama, H., and Takahashi, T.A. Generation of dendritic cells from fresh and frozen cord blood CD34+ cells. Cryobiology, 37: 362-371, 1998
1996
Sato, K., Yoo, Y.C., Matsuzawa, K., Watanabe, R., Saiki, I., Tono-oka, S., and Azuma, I. Tolerance to the antimetastatic effect of lipopolysaccharide against liver metastasis in mice. Int. J. Cancer, 66: 98-103, 1996
1995
Sato, K., Yoo, Y.C., Mochizuki, M., Saiki, I., Takahashi, T.A., and Azuma, I. Inhibition of tumor-induced angiogenesis by a synthetic lipid A analogue with low endotoxicity DT-5461. Jpn. J. Cancer Res., 86: 374-382, 1995
Sato, K., Yoo, Y.C., Fukushima, A., Saiki, I., Takahashi, T.A., Fujihara, M., Tono-oka, S., and Azuma,I. A novel synthetic lipid A analogue with low endotoxicity, DT-5461, prevents lethal endotoxemia. Infect. Immun., 63: 2859-2866, 1995
Mochizuki, M., Yoo, Y.C., Matsuzawa. K., Sato, K., Saiki, I., Tono-oka, S., Samukawa, K., and Azuma, I. Inhibitory effect of tumor metastasis in mice by saponines, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol. Pharm. Bull., 18: 1197-1202, 1995
Sato, K., Fujihara, M., Takahashi, T.A., Yoo, Y.C., Hata, K., Tono-oka, S., Suzuki, T., Sekiguchi, S., and Azuma, I. Endotoxin antagonism by a synthetic lipid A analogue, DT-5461, with low endotoxicity in human peripheral blood monocytes.Biochem. Biophys. Res.Commun., 216: 367-374, 1995
1994
Yoo, Y.C., Saiki, I., Sato, K., and Azuma, I.MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, inhibits the metastasis of hematogenous and non-hematogenous tumor in mice. Vaccine, 12: 175-180, 1994
Sato, K., Mochizuki, M., Saiki, I., Yoo, Y.C., Samukawa, K., and Azuma, I. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol. Pharm. Bull., 17: 635-639, 1994
Yoshida, R., Sato, K., Yoo, Y.C., Yoshimatsu, K., Tamura, M., Ishihara, C., Arikawa, J., and Azuma, I. Effect of the synthetic lipid A-related compound, DT-5461, on resistance to sendai virus infection in mice. Immunopharmacology, 28: 153-161,1994
1992
Saiki, I., Sato, K., Yoo, Y.C., Murata, J., Yoneda, J., Kiso, M., Hasegawa, A., and Azuma, I. Inhibition of tumor-induced angiogenesis by the administration of recombinant interferon-? followed by a synthetic lipid A analogue (GLA-60). Int. J. Cancer, 51: 641-645, 1992
Sato, K., Saiki, I., Yoo, Y.C., Igarashi, Y., Kiso, M., Hasegawa, A., and Azuma, I. DT-5461, a new synthetic lipid A analogue, inhibits lung and liver metastasis of tumor in mice. Jpn. J. Cancer Res., 83: 1081-1087, 1992
Yoo, Y.C., Saiki, I., Sato, K., and Azuma, I. B30-MDP, a synthetic muramyl dipeptide derivative for tumor vaccination to enhance antitumor immunity and antimetastatic effect in mice. Vaccine, 10: 792-797, 1992