Author Archives: kokusai

Summary

We are interested in the functional morphology of the gastric parietal cells associated with gastric acid secretion. Our recent studies are being carried out by taking the advantages of original ex vivo experimental model named “iGM” standing for isolated gastric mucosa processed by high-pressure freezing. Another aspect of our collaborative research concerns ultrastructural analysis of the iPS cell-derived blood cells, such as the megakaryocyte, platelet, erythroblasts, etc.

Education

  1. Clinical gross anatomy
  2. Basic life science
  3. Sports anatomy for professional athletes

Research Projects

  1. Functional morphology of the gastric parietal cells
  2. Innovation of electron microscopy
  3. Ultrastructural analysis of the iPS cell-derived blood cells
  4. Collaborative observation by live imaging and electron microscopy
  5. Establishment and characterization of cancer cell lines

Laboratory Techniques

  1. Histochemistry (including immuno- and lectin-histochemistry at the electron microscopic level using gold labeling)
  2. High-pressure freezing for electron microscopy
  3. Transmission and scanning electron microscopy
  4. Molecular biological analysis on cultured cell lines

Publications

  1. Takahashi, N. et al.: Establishment and biological characterization of a novel cell line derived from hepatoid adenocarcinoma originated at the ampulla of Vater..
    J Int Oncol, 44: 1139-45, 2014
    *collaborative contribution
  2. 2. Toshima, J.Y. et al.: Bifurcation of the endocytic pathway into Rab5 dependent and independent transport to the vacuole.
    Nature Commun, 5: 3498. doi: 10.1038/ncomms4498, 2014
    *collaborative contribution
  3. Nakamura, S. et al.: Expandable megakaryocyte cell lines enable clinically-applicable generation of platelets from human induced pluripotent stem cells.
    Cell Stem Cell, 14: 535-548, 2014
     *collaborative contribution
  4. Hirose, S., et al.: Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells.
    Stem Cell Reports, 1: 499-508, 2013.

Summary

The principal research focus in our department involves programs devoted to the molecular, nutritional, and genetic bases for leukemia/cancer and other common life-style related diseases. Four faculty members with many foreign postgraduate students pursue research linked to human diseases, including adult-T cell leukemia (ATL) with HTLV-1 infection, the patients of which are mainly accumulated in the southern part of Kyushu island including Miyazaki.

Research Projects

A broad spectrum of technical approaches utilizing the tools of enzymology, molecular biology, and genetics is being used to understand the origins of diseases which are common in our population. Among the studies underway are analyses of the inheritance and genetic analysis of cancer, mechanisms of resistance to anti cancer drugs by stress response (Nature comm 2014), which is related to leukemia stem cells with EVI1 (Cell 1988) or MEL1/PRDM16 transaction factors (Blood 2000), and altered metabolic function by AMPK linked to altered glucose metabolism (Cell stem cell 2015). Faculty members in this research area collaborate in a wide variety of studies with investigators in basic sciences and clinical faculties at both nationally and internationally. These investigations include basic research into the metabolism of drugs and environmental toxins, apoptosis, analyses of metabolism and gene regulation in normal and cancer cells, and direct diagnosis of cancer, diabetes, and other disorders in humans by molecular genetic and immunological techniques.

Laboratory Techniques

  1. Maintenance and handling of mammalian cells
  2. Basic molecular biology techs (e.g., PCR, Sanger sequencing, transformation, stem cell culture, iPS)
  3. NGS (next generation DNA sequencers) sequencing and bioinformatics
  4. Antibody production by phage display and development of molecular target therapy
  5. Generation of genetically modified mouse (Cre/lox, CRISPR/Cas)
  6. Mass spectrometry analysis

International Collaboration

  1. Department of Internal Medicine, Prince of Songkla University, Thailand
  2. Faculty of Veterinarian Science, Chulalongkorn University, Thailand
  3. Faculty of Medicine, Gadjah Mada University, Indonesia

Publications

  1. Saito Y, Chapple R, Lin A, Kitano A, Nakada D.AMPK protects leukemia-initiating cells of MLL-rearranged acute myeloid leukemia from metabolic stress in the bone marrow. Cell Stem Cell. 2015
  2. Ichikawa T, Nakahata S, Fujii M, Iha H, Morishita K. Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development. Scientific Reports 5:12841 (2015)
  3. Ichikawa T, Nakahata S, Tamura T, Manachai N, Morishita K. The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β. Cell Signal. 27:2087-98. 2015
  4. Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nature Comm. 5: 3393 (2014)
  5. Saito Y, Kaneda K, Suekane A, Ichihara E, Nakahata S, Yamakawa N, Nagai K, Mizuno N, Kogawa K, Miura I, Itoh H, Morishita K : Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. Leukemia 27: 1637-1649 (2013)

Summary

Our laboratory focuses on the pathogenesis of atherosclerosis, atherothrombosis, venous thromboembolism and thrombosis and hemostasis in obstetric disease. Thrombosis is a disease caused by a blood clot (thrombus). Thrombus may form in any part of the cardiovascular system, including arteries, veins the heart and the microcirculation. Arterial thrombi usually develop on the disrupted atherosclerotic lesions, causing myocardial infarction and ischemic stroke, etc. Venous thrombi likely occur in the lower limbs, which is a major cause of pulmonary thromboembolism. In this way, the thrombi can lead to serious complications. However, the mechanisms of thrombus formation and propagation remain unclear, because many factors, such as vessel wall constituents, local hemorheology, systemic thrombogenicity, also immune and inflammatory reactions, are involved in the process. We are studying the issues from the viewpoint of human and experimental pathology.

Research Projects

  1. Pathology of thrombosis
  2. Mechanisms of thrombus formation
  3. Atherogenesis and atherosclerotic plaque thrombogenicity
  4. Imaging of atherosclerosis and thrombosis
  5. Cancer-associated thrombosis and hemorrhage
  6. Thrombosis and hemostasis in obstetric disease

Laboratory Techniques

  1. Histological analysis
  2. Rabbit models of atherosclerosis and thrombosis
  3. Blood flow chamber
  4. Cell culture
  5. Imaging modalities

Publications

http://www.med.miyazaki-u.ac.jp/home/pathophysiology/works/

 

 

Summary

Our primary research interest focuses on the molecular basis of neurodegenerative diseases due to abnormal aggregation of protein, including Prion diseases (PrD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD). We recently established a highly sensitive cell-free prion conversion assay, designated “real-time quaking-induced conversion (RT-QUIC),” for detection of a tiny amount of prion in the samples. Accumulating evidence showed that this assay is useful for the diagnosis and drug screening for PrD. By developing the principal of the cell-free protein conversion assay, we would like to establish the diagnostic method for other neurodegenerative diseases, especially DLB and AD. Furthermore, we also investigate the development of effective drugs for PrD, DLB, and AD.

 

Research Projects

  1. Development of highly sensitive diagnostic assay for Neurodegenerative diseases
  2. Novel drug screening for prion diseases and Alzheimer diseases
  3. Molecular basis of prion formation and prion strain phenomenon
  4. The origin of biological homochirality

Laboratory Techniques

  1. Basic techniques for molecular biology, biochemistry, cell biology, and microbiology
  2. Conformational analysis of protein (e.g. FTIR, CD, Thermal stability assay)

International Collaboration

  1. TSE/Prion Biochemistry Section, Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
  2. The National CJD Research and Surveillance Unit, University of Edinburgh
  3. Department of Pathology, Mental Health Research Institute of Victoria, The University of Melbourne

Publications

  1. McGuire LI, Poleggi A, Poggiolini I, Suardi S, Grznarova K, Shi S, de Vil B, Sarros S, Satoh K, Cheng K, Cramm M, Fairfoul G, Schmitz M, Zerr I, Cras P, Equestre M, Tagliavini F, Atarashi R, Knox D, Collins S, Haïk S, Parchi P, Pocchiari M, Green A. CSF RT-QuIC is a robust and reliable test for sporadic CJD: An international study. Ann Neurol. 2016 Apr 30.
  2. Mori T, Atarashi R, Furukawa K, Takatsuki H, Satoh K, Sano K, Nakagaki T, Ishibashi D, Ichimiya K, Hamada M, Nakayama T, Nishida N. A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion. Sci Rep. 2016 Apr 26;6:24993.
  3. Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N. Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS One. 2015 Jun 12;10(6):e0126930.
  4. Sano K, Atarashi R, Ishibashi D, Nakagaki T, Satoh K, Nishida N. Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion. J Virol. 2014 Oct;88(20):11791-801.
  5. Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R. FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy. 2013 Sep;9(9):1386-94.
  6. Sano K, Satoh K, Atarashi R, Takashima H, Iwasaki Y, Yoshida M, Sanjo N, Murai H, Mizusawa H, Schmitz M, Zerr I, Kim YS, Nishida N. Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS One.
  7. Ishibashi D, Atarashi R, Fuse T, Nakagaki T, Yamaguchi N, Satoh K, Honda K, Nishida N. Protective role of interferon regulatory factor 3-mediated signaling against prion infection. J Virol. 2012 May;86(9):4947-55.2013;8(1):e54915.
  8. Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med. 2011 Feb;17(2):175-8. 
 

Division of Hepato-Biliary-Pancreas Surgery

Since the Miyazaki University opened, the field of hepato-biliary-pancreas surgery has been developed in both first and second department of surgery by each strategy or techniques. Eventually, this group has newly started according to reunion of the department of surgery since April 2016.

At this stage, HBP clinical works is instructed by the professor and chairman, Atsushi Nanashima and the divisions divided by two groups with the associate professor, Yoshiro Fujii and Jiro Ouchida, the assistant professors, Masahide Hiyoshi, Naoya Imamura, Koichi Yano, Takeomi Hamada and Yuki Tsuchimochi as expert staffs. We perform the highly advanced liver and pancreas surgery, operations for biliary maljunctions or endoscopic examinations or treatments in a large number of patients. The laparoscopic liver and pancreas surgery has been also increased under the indication covered by the health insurance.

In the research works, researches for tumor immunology, surgical site infections, preoperative biliary drainage, biliary reconstruction, digestive tract reconstruction after pancreaticoduodenectomy, usefulness of liver GSA scintigraphy have been historically performed. Graduate students were studied the new bio-markers to indicate malignant behaviors in malignancies of the HBP field. As a new research, basic and clinical research trial of photodynamic therapy for bile duct carcinomas is started this year.

Surgical works of HBP surgery has been intensificated to university hospital and the patients are referred from the places in the entire Miyazaki prefecture. By joing the new staffs of the internal medicine specialized biliary and pancreas diseases, the general power of HBP clinics can be improved in the near future. We are waiting for the new young staffs to aim the world level quality together with professor Nanashima and colleagues together!

Professor and Chairman: Atsushi Nanashima, MD, PhD.

Division of the Gastrointestinal, Endocrine and Pediatric Surgery

At the time of April, 2015, the former the first and second department of surgery have been united and the new division of the gastrointestinal, endocrine and pediatric surgery is established.

Group of the gastrointestinal and endocrine surgery

Our clinical works includes the general surgery with the gastrointestinal and endocrine diseases. With respect to the digestive tract diseases as gastric and colorectal cancers, endocrine diseases as thyroid cancers or Basedow diseases (hyperthyroidism), the improvement of treatment efficacy from the preoperative evaluation, perioperative managements to the postoperative treatments are always aimed. We also do efforts for acute difficult abdominal diseases (perforation, obstruction of the intestines and peritonitis) or acute advanced trauma surgery by the collaboration with other surgical staffs, aggressively at every single day.

Not only promoting the expert young surgeons in the field of the gastrointestinal and endocrine surgery but also training surgeons who can correspond the any difficult situations are aimed. For the patients who undergo operation safely in Miyazaki, our staff attempt to do full effort to establish the best surgical group by considering the traditional works and the new advanced skills.

Pediatric group

At this stage, only one expert pediatric surgeon perform surgical works by co-operating of other surgical staffs and the University of Kagoshima. Min diseases are inguinal hernia, undescended testes, Hirschsprung disease, the infant congenital diseases as the diaphragmatic hernia, intestinal atresia, imperforated anus and so on. As emergency diseases, appendicitis or infantile perforation intestines are treated. When the infants with small body weightless than 1000g, my performance is activated in such a case. The young surgeons can experience the wide field of pediatric diseases at our group. This group is good for young doctors who are curious and aggressive for medicines. By co-operating with other members or medical institutes, we aim to contribute the pediatric surgery in Miyazaki as well as possible.

Chairman: Takuto Ikeda, MD, PhD.

Division of Cardiovascular Surgery

This group is instructed by the professor, Kunihide Nakamura (graduated in 1981) and consisted of other six expert surgeons, who perform the daily clinics, education and research works. The main diseases which we treat arecardiac valvular disease, ischemic heart disease as angina or cardiac infarction, congenital heart diseases, thoracic or abdominal aortic aneurysm, atherosclerosis and limb varices. The number of total operation in 2014 was 241 cases including open heart surgery in 136 ((acquired in 114 and congenital in 22), abdominal aneurysm (laparotomy in 24 and stent graft technique in 38) and others (the lower limb reconstruction or varices) in 105 cases. At November 2015, the hybrid operation room has been opened to use and, thus we aim to increase stent-graft treatments or trans-catheter aortic valve treatments. Dr Syuhei Sakaguchi (graduated in 2009) went to learn at Fukuoka municipal children hospital and Katsuya Kawagoe (2009, graduated at Yamaguchi University) joined the cardiovascular group of Miyazaki city and county hospital this year.

With respect to research works, graduate students, Masanori Nishimura (2002 graduated at Shimane University) studies mechanism of atherosclerosis at the department of Pathology (prof Asada group), Atsuko Yokota (2004) studies the mechanism of vascular contractions at the first department of pharmacology of Kyusyu health and wealfare university (prof Ryuuichi Yamamoto) and Mitsuyuki Furukawa (1995 graduated at Yamaguchi university) are newly going to study

The present cardiovascular group adopts the latest treatments and performs the research works with good balance of performances. Recently, young surgeons join our department and the associated hospitals have been increased. Our performance is still insufficient and, however, we attempt to work by self-efforts to aim the world standard levels.

Professor and Chairman: Kunihide Nakamura, MD, PhD.

Division of the Thoracic and Breast surgery

Since April 2015, the department of Surgery was newly established and the division of respiratory and breast surgery has been started. The associate professor, Masaki Tomita (Hospital professor, graduated in 1988), the assistant professor, Takanori Ayabe (hospital associate professorat the section of medical safety management graduated in 1991), the associate professor Eiichi Chosa (graduated in 1992 and colleagues performed the outpatient clinic, the ward clinic and related education or research works. The main subject diseases are pulmonary diseases including lung carcinoma, tracheal or bronchial tumor, pneumothorax, thoracic wall tumor, mediatinal tumor, diaphragmatic diseases and thoracic trauma. The number of operation ahs been increased. Although the clinical staffs are chronically insufficient, the expert surgeons spend the great works by the full manpower day by day. The new resident has not belonged and, however, Dr. Hiroki Mori (graduated in 2012), Mayumi Kawasaki (2012) et al. joined to be a respiratory surgeon recently, who activate the department atmospheres.

In the clinical research, the induction chemotherapy for lung cancers, identification of prognostic tumor markers, the chemotherapy combined hyperthermia for thoracic disseminated malignant diseases have been progressed. Under the insufficient manpower, these works were established as well as possible. Even though thi situations, The seven English articles were published last year, and still the five articles have been accepted in-press this year.

As a new department, the professor Nanashima was invited since this April and were going to do full efforts to develop surgical works in Miyazaki. As one of these trial, the conference regarding respiratory and breast surgery in Miyazaki or other attempts have been started. Breast cancer patients tended to have the variety of anxiety with respect to operation or anti-cancer chemotherapy, tumor recurrence, cosmetic problems of surgical wounds, the lymphatic edema, mental or economic problems and so on. We aim to solve these problems together with the warm hearts in these patients.

Our department provides the nationwide standard examination, operation, chemotherapy and brachytherapy according to the Japan guideline. Furthermore, the adequate treatments are always considered and undergone in each patient. We recommend to consult our department if the patients with breast diseases are aware of the daily life. Please come to our hospital with ease mind. Again, the chronic lack of staffs is continued and, however, we aim to go forward by talking the attractive surgical works to medical students or internship young doctors to join our team.

Chairman: Masaki Tomita, MD, PhD.

Division of Plastic Surgery

Plastic surgery is a field of wound repair expert division to improve the patient condition by operation cosmetically or functionally, or to improve the patient quality of life. Therefore, the field of treatment is variety in the entire body.

In detail:
・Face trauma, fracture or postoperative deformation
・Scars (contracture, thickness, keloid)
・Burn
・Anomaly of head, face, the body, limb as congenital drooping eyelid, synpolydactyly
・Benign neoplasm as stain, nevus, atheroma, hemangioma etc.
・Reconstructions after wide resection for malignant diseases
・Incurable dermal ulceration
・Others(deformation of nails, face paralysis, drooping eyelid by aging, body odor etc.)

We can consult any other diseases at the body surface by the plastic surgical treatments.

Our group has chances to co-operate with other divisions and the high level of quality can be provided by facing each patient with warm heart as the expertized team. We also contribute the department of surgery in Miyazaki by performing high quality medicine. Please come and join us!

Chairman: Hiroshi Ito, MD, PhD.

Thank you for visiting the official site of the Department of Urology at University of Miyazaki. The Department of Urology has a long tradition of serving the needs of Miyazaki Prefecture by delivering the highest quality healthcare. As Miyazaki’s central urological service, we treat a wide range of urologic problems, from the routine to the rare. Please take some time to read through our page to familiarize yourself with the specialized areas of treatment we offer.

 

Toshiyuki Kamoto, M.D., Ph.D.
Chairman
Department of Urology
Faculty of Medicine
University of Miyazaki

Major subspecialties

Urological oncology

In the area of urological oncology we treat a wide range of diseases such as malignant tumor of the urinary tract (kidney, ureter, urinary bladder, urethra), male genitalia (prostate, seminal vesicle, testis, penis) and retroperitoneal organs (adrenal gland, retroperitoneal tumor etc.).
The surgical treatment available here includes laparoscopic surgery (total resection of kidney, prostate and urinary bladder, partial resection of kidney and urinary bladder), open surgery (resection for renal cell carcinoma with IVC extension, urinary diversion etc.), and transurethral endoscopic surgery (transurethral resection of tumor in urinary tract).
Non-surgical treatment options include chemotherapy, molecular targeted therapy, androgen deprivation therapy, and external beam radiotherapy.      Other options are multimodal treatment for advanced cancer, palliative care, cancer prevention, and active surveillance for prostate cancer and small renal masses.

Pediatric urology

In pediatric urology, we mainly focus on cryptorchidism, vesicoureteral reflux (VUR), hypospadias, congenital hydronephrosis due to ureteropelvic junction obstruction (UPJO) and ureterovesical junction obstruction (UVJO).
Surgical treatment includes orchidopexy, ureterocystostomy, urethroplasty and pyeloplasty.

Voiding dysfunction

In the area of voiding dysfunction we treat benign prostatic hyperplasia (BPH), urethral stricture, and neurogenic bladder.
Specific examinations performed in the department include pressure-flow study and video urodynamics.
Our surgical treatment includes holmium laser enucleation of the prostate (HoLEP), and transurethral surgery.

Other

In the area of female urology we provide tension-free vaginal mesh (TVM) for pelvic organ prolapse, and trans-obturator tape (TOT) surgery for stress incontinence.
We also offer hydraulic pressure therapy for the treatment of interstitial cystitis.
In addition, we started living related kidney transplant.

Major clinical research

1)    Cohort study of BPH patients in Miyazaki prefecture
2)    Prospective study on voiding function using “Flow-sky”
3)    Cohort study of renal cell carcinoma patients in Miyazaki prefecture
4)    Prospective study on the clinical relevance of partial nephrectomy
5)    Retrospective clinicopathological analysis of the expression of growth factor-related protein in urological malignancy by immunohistochemistly

As an integral part of the community healthcare system we apply the most advanced medical technologies to a broad range of diagnostic and therapeutic strategies to meet and exceed the expectations of the patients we serve. We welcome visitors who wish to learn more about the urological care we offer here at the University of Miyazaki’s Department of Urology.

Research in the Department of Urology prioritizes practical science that contributes to actual medical treatment. Postgraduate students in the department are also actively involved in research, and their studies can be found in prestigious international journals.
The department’s main areas of research are urogenital oncology and nephrogenesis, and we actively collaborate with individuals and groups involved in basic research. A quick look at the projects and publications listed below shows the department’s extensive involvement in basic and clinical studies.

Toshiyuki Kamoto, M.D., Ph.D.
Chairman
Department of Urology
Faculty of Medicine
University of Miyazaki

Ongoing Research Projects

  1. Identifications of clinically relevant molecular markers for urogenital cancers
  2. Analysis for “failure of ureteric bud invasion (FUBI)”: Using a new model of renal agenesis in mice
  3. Analysis of DNA polymorphisms in carcinogenesis and progression of urogenital cancers
  4. Identifications of molecular mechanism in metastasis of urogenital cancer: Using animal model

Laboratory Techniques

  1. Basic molecular biology techniques (e.g., PCR, Cell cultures)
  2. Immunological examination (e.g., ELISA, Western blotting analysis)
  3. Morphological analysis (e.g., Scanning and transmission electron microscopy, Immunohistochemistry)
  4. Animal experiments

Collaboration

  1. Department of Urology, Kyoto University, Kyoto, Japan
  2. Laboratory Medicine, Faculty of Health Care, Tenri Health Care University, Nara, Japan
  3. Laboratory of Veterinary Biochemistry and Molecular Biology, Miyazaki University, Miyazaki, Japan

Publications

  1. Dysregulated HAI-2 plays an important role in renal cell carcinoma bone metastasis through ligand-dependent MET phosphorylation, Yamasaki K, Mukai S, Sugie S, Nagai T, Nakahara K, Kamibeppu T, Sakamoto H, Shibasaki N, Terada N, Toda Y, Kataoka H, Kamoto T. Cancers. 2018, 10(6)
  2. Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression., Sugie S, Mukai S, Yamasaki K, Kamibeppu T, Tsukino H, Kamoto T. Cancer Genomics Proteomics. 2015, 12(6):391-396.
  3. Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis., Mukai S, Yorita K, Kawagoe Y, Katayama Y, Nakahara K, Kamibeppu T, Sugie S, Tukino H, Kamoto T, Kataoka H. Hum Cell. 2015, 28(1):44-50
  4. Plasma macrophage-stimulating protein and hepatocyte growth factor levels are associated with prostate cancer progression., Sugie S, Mukai S, Yamasaki K, Kamibeppu T, Tsukino H, Kamoto T. Hum Cell. 2015, [Epub ahead of print], PMID:26250899.
  5. Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis., Mukai S, Yorita K, Yamasaki K, Nagai T, Kamibeppu T, Sugie S, Kida K, Onizuka C, Tsukino H, Kamimura T, Kamoto T, Kataoka H. Hum Cell. 2015, 28(3):133-142.
  6. Cyclooxygenase 2 Genotypes Influence Progression of Prostate Cancer Susceptibility in Japanese Men., Sugie S, Tsukino H, Mukai S, Akioka T, Shibata N, Nagano M, Kamoto T. Tumor Biology. 2014 Mar;35(3):2717-21. doi: 10.1007/s13277-013-1358-y.
  7. Effect of Dutasteride on Microvessel Density in Benign Prostatic Hyperplasia., Sugie S, Mukai S, Tsukino H, Iwamoto H, Kobayashi T, Toda Y, Kamoto T.In Vivo. 2014 May-June; 28(3):355-60.
  8. Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis., Mukai S, Yorita K, Kawagoe Y, Katayama Y, Nakahara K, Kamibeppu T, Sugie S, Tukino H, Kamoto T, Kataoka H. Hum Cell. 2014 Sep 4.
  9. Functional Polymorphism in the CAV1 T29107A Gene and Its Association with Prostate Cancer Risk among Japanese Men., Sugie S, Tsukino H, Yamauchi T, Mukai S, Fujii M, Shibata N, Kuroda Y, Kamoto T. Anticancer Res. 2013 Mar;33(3):1023-7.
  10. Increased Plasma Caveolin-1 Levels Are Associated with Progression of Prostate Cancer among Japanese Men., Sugie S, Mukai S, Tsukino H, Toda Y, Yamauchi T, Nishikata I, Kuroda Y, Morishita K, Kamoto T. Anticancer Res. 2013 May;33(5):1893-7.
  11. Analysis of multimodal treatment outcome in renal cell carcinoma patients with bone metastasis., Mukai S, Tsukino H, Goto T, Sugie S, Shitamura T, Kamimura T, Kamoto T. Hinyokika Kiyo. 2013 Apr;59(4):207-12. Japanese.

At the University of Miyazaki Hospital Department of Dermatology, founded in 1977, comprehensive diagnosis and treatment are performed while coordinating operations with various departments as a core hospital of Miyazaki prefecture.
The department provides specialized treatment for diseases including skin cancer and severe burns, as well as skin disorders such as psoriasis vulgaris, atopic dermatitis and phacomatosis.
The department conducts twice-weekly teaching rounds and ward conferences, weekly diagnostics at clinical conferences, makes decisions on treatment strategies and evaluates therapeutic outcomes.

Particularly strong areas

  • Pathodiagnosis of the skin, and multimodal treatment for conditions including severe burns, skin cancer, and phacomatosis.

Ongoing clinical research

  • Analysis of the underlying mechanism of adult T-cell leukemia/lymphoma skin invasion
  • The relationship between propionibacterium acne and lupus miliaris disseminatus feciei

Overseas cooperation

  • Miami University, Florida State, United States

Our ophthalmology department can accept all kinds of eye disease as shown below. Through this management and treatment, we identify many kinds of problems and questions. We resolve these using state of the art ophthalmological instruments, discussion, and basic researches. Therefore, our department is full of conversation, many machines for diagnosis and treatment, clinical and basic research, and patients’ smiles. We would like to share these with you. For residents, we offer 4-year training courses in which sufficient quality and quantity of clinical experiences are provided with our good teaching staffs that enables them to pass the ophthalmology subspecialist examination.

Major Ophthalmology subspeciality

  1. Retina and vitreous: Surgical and medical treatment for retina and vitreous diseases including macular holes, proliferative diabetic retinopathy, rhegmatogenous retinal detachment, age-related macular degeneration, retinopathy of premarurity, and retinitis pigmentosa.
  2. Neuro-Ophthalmology: diagnosis and treatment for ischemic optic neuropathy, optic neuritis, and diplopia.
  3. Glaucoma: Surgical and medical treatment for open angle, angle closure and congenital glaucoma.
  4. Pediatric ophthalmology &strabismus: we have performed the most numbers of strabismus surgeries in Kyushu.
  5. Cornea: Surgical and medical treatment for corneal ulcer.
  6. Oculoplastic: Surgical and medical treatment for ptosis, nasolacrimal obstruction, and orbital diseases.

Main clinical researches

  1. ROP treatment trial
  2. AMD treatment trial
  3. Ischemic optic neuropathy treatment trial

Extramural activities

  1. University of Michigan, Kellogg eye center
  2. Eye Hospital of Wenzhou medical University

Basic research

  1. Development of effective treatment for nonarteritic ischemic optic neuropathy (NAION) using rodent model of NAION
  2. Pharmacological effect for isolated rabbit posterior ciliary artery
  3. Molecular pathogenesis of inherited retinal disease
  4. Molecular analysis of ocular infectious disease

Administration

Chairman’s office
Phone: +81-985-85-2806
Fax: +81-985-84-2065
Email: megumi_kawano@med.miyazaki-u.ac.jp