Identification and Pathological Analysis of Biologically Active Peptide
Information for Exchange Students
Name of the department: Division for Identification and Pathological Analysis of Biologically Active Peptide, Frontier Science Research Center, University of Miyazaki
Name of the research project: Biologically active peptides: from identification of unknown peptides to clinical application
Head of the department: Professor Johji Kato, MD, PhD
Tutor(s): Associate Professor Kenji Kuwasako, MD, PhD
Duration of the project: One month
Period of year: all year except from Aug 13 to 15 and Dec 29 to Jan 3
Acceptable number of students (per period/per year): 1/period, 4/year
Description of the project (including, relation to the main work of the laboratory, procedures and methods used in the project):
We are doing research on the field ranging from the basic medicine to clinical sciences with the most important keyword being “biologically active peptide”. A number of biologically active peptides are involved in regulating the physiological functions of the mammals, including blood pressure and body fluid balance. To isolate unknown peptides, establishing a bioassay for detection of biological activity is essential. We have tried to develop the method, utilizing cultured cells stably expressing orphan receptors and cellular internalization of the receptors, to discover novel bioactive peptides. It is also challenging to identify unknown functions or pathophysiological roles of known peptides by cell culture, animal experiments, or clinical studies. By doing so, we may be able to propose possibility of biologically active peptides as therapeutic or diagnostic tools. The peptides we have mainly studied during the past decades are those regulating blood pressure and fluid volume such as natriuretic peptides, adrenomedullin, CGRP, and angiotensins.
Exchange students or researchers who join in our laboratory would learn the methods of cell culture, animal experiments, and clinical studies, which are essential to the above-described research on biologically active peptides.
Aim of the project: “Biologically active peptide” is a research field characteristic of the University of Miyazaki. The aim of this project is to understand a series of steps ranging from identification of unknown peptides to clinical application as a therapeutic or diagnostic tool.
Requirements (if special knowledge is needed): It would be helpful for you if you have a background of biology, biochemistry, physiology, or basic or clinical medicine.
Further information from:
Johji Kato, MD, PhD