Internal medicine 2

Information for Exchange Students



Name of the department: Division of Gastroenterology and hematology, Department of Internal medicine, Faculty of Medicine, University of Miyazaki

Head of the department: Professor Kazuya Shimoda, MD, PhD

Tutor(s): Professor Kazuya Shimoda, MD, PhD

Associate Professor Kenji Nagata, MD, PhD

Language(s): English/Japanese

Duration: Two week*(please choose one month or two weeks)

Period of year: January 10 to March 30

Acceptable number of students (per period/per year): 2/period, 4/year


Clinical training:

Details of the clinical training and training contents

Our department consists of The Hematology section and The Gastroenterolgy and Hepatology section.  The student(s) who joins our training would learn specialized and most advanced contents as follows.

(1) Gastroenterology and Hepatology


Watching: abdominal ultrasonography (including contrast enhanced US), liver

biopsy, gastric endoscopy, colonic endscopy.

Practice: Training simulator: US, GI endoscopy.

・Endoscopic/US guided therapeutic procedure

Endoscopic mucosal resection, endoscopic submucosal dissection for

gastrointestinal tumor, etc.  Radiofrequency ablation therapy.

・Training for interpretation of liver blood tests, and abdominal imaging

(MR, CT, etc)

(2) Hematology

・Training for clinical diagnosis and treatment of hematological malignancy patient.

・Watching bone marrows aspiration and biopsy procedure.

・Training for evaluation of bone marrow aspiration and peripheral blood smear.

・How to use the anticancer drug


Research Project:

Name of the project: Molecular analysis of Myeroproliferative disease.

Description of the project (including, relation to the main work of the laboratory, procedures and methods used in the project):

The myeloproliferactive diseases (MPDs) are a group of diseases of the bone marrow in which excess cells are produced.  They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the MPDs on the whole have a much better prognosis than these conditions.  Janus kinase 2 (commonly called JAK2) is a human protein that has been implicated in signaling by members of the type II sytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors.  JAK2 mutation in blood cell is often detected in the patient of primary myelofibrosis (up to 50%), polycythemia vera (up to 80 %) and essential thrombocytosis (up to 20 %).  We established the JAK2 mutant transgenic mouse model and have been analyze the mechanism of MPDs with this TG mouse.  We have used combining FACS, DNA microarray system, mouse bone marrow transplantation and retroviral gene transfer etc.

The student(s) who joins our laboratory would work on the project proceeding at the team and learn techniques including biochemistry and molecular biology as follows.

1. Handling and analysis of DNA by cloning, sequencing, PCR, and protein expression and functional analysis of the genes.

2. Protein chemistry of transcription factors.

3. Analyses of animal models of diseases and transgenic animals.


Requirements (if special knowledge is needed): No special knowledge is needed.


Further information from:

Satoru Hasuike