Information for Exchange Students
Name of the department: Department of Pathology, Division of pathophysiology, Faculty of Medicine, University of Miyazaki
Name of the research project: Pathological investigations on thrombogenesis and atherogenesis.
Head of the department: Professor Yujiro Asada, MD, PhD
Tutor(s): Associate Professor Kousuke Marutsuka, MD, PhD
Assistant Professor: Kinta Hatakeyama, MD, PhD
Research associate: Yuichiro Sato, MD, PhD; Atsushi Yamashita, MD, PhD
Duration of the project: One month
Period of year: all year except from July 15th to 30th, Dec. 25th to Jan. 6th
Acceptable number of students (per period/per year): 1/period, 4/year
Description of the project (including, relation to the main work of the laboratory, procedures and methods used in the project): Our laboratory focuses on the pathogenesis of thrombosis and atherosclerosis. Thrombosis is the formation of a blood clot (thrombus). Thrombus may form in any part of the cardiovascular system, including arteries, veins the heart and the microcirculation. Arterial thrombi usually develop on the disrupted atherosclerotic lesions (atherothrombosis), causing myocardial infarction and ischemic stroke, etc. Venous thrombi usually occur in the lower limbs, which is a major cause of pulmonary thromboembolism. Thrombi are composed of fibrin and blood cells. However the mechanisms of thrombus formation and propagation remain unclear, because many factors, such as vessel wall constituents, local hemorheology, systemic thrombogenicity, also immune and inflammatory reactions, are involved in the process. We have studied the issue from the viewpoint of human and experimental pathology, and have elucidated the crucial role of vascular tissue factor and blood flow alteration.
The student(s) who joins our laboratory would learn;
- fundamental mechanisms of thrombogenesis and atherogenesis
- techniques for morphological examination and molecular pathology
- laboratory tests of platelet function and coagulation pathway
- development and analyses of animal models with thrombotic disorders.
Aim of the project: Thrombosis is the most significant cause of disability and death in the world. I hope that medical knowledge gained from this project would be instrumental for further researches and clinical practice.
Requirements (if special knowledge is needed): No special knowledge is needed, but students who are interested in the research field are highly recommended.