2024

(72) Akieda-Asai S, Ma H, Han W, Nagata J, Yamaguchi F, Date Y: Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes established by using a soft-pellet diet. Scientific Reports. 14,7670 (2024)

2021

(71) Horii Y, Nakajima S, Akieda-Asai S, Ohta R, Kawaguchi M: Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in Hatano rats. Physiol Behav 229:113209 (2021)

(70) Jang Y, Heo J, Lee M, Zhu J, Seo C, Go D, Yoon S, Date Y, Oike Y, Sohn J-W, Shong M, Kweon G: Angiopoietin-like growth factor involved in leptin signaling in the hypothalamus. Int J Mol Sci 22(7) (2021)

2019

(69) Akieda-Asai S, Ma H, Date Y: Palmitic acid induces guanylin gene expression through the Toll-like receptor 4/nuclear factor-κB pathway in rat macrophages. Am J Physiol Cell physiology 317(6):C1239-C1246 (2019)

(68) 喜多 也寸志, 伊達 紫, 中里 雅光, 山下 太郎, 安東 由喜雄, 吉田 幸司, 寺澤 英夫, 清水 洋孝, 上原 敏志: Val107ATTR変異を認めたFAP兄弟例. 臨床神経学 59(10):674-674 (2019)

(67) Koike H, Nakamura T, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Yasuda T, Mukai E, Date Y, Shiomi K, Nakazato M, Katsuno M, Sobue G: Common clinicopathological features in late-onset hereditary transthyretin amyloidosis (Ala97Gly, Val94Gly and Val30Met). Amyloid: Int J Exp Clin Investig: Off J Int Soc Amyloidosis 26(sup1):24-25 (2019)

2018

(66) Han W, Utoyama M, Akieda-Asai S, Hidaka A, Yamada C, Hasegawa K, Nunoi H, Date Y: Influence of food texture on energy metabolism and adiposity in male rats. Exp Physiol 103(10):1347-1356 (2018)

(65) Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y: Interleukin-15 derived from Guanylin–GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.Peptides 99:14-19 (2018)

2017

(64) Yasuda M, Kawabata J, Akieda-Asai S, Nasu T, Date Y: Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue. J Vet Sci 18(3):341-348 (2017)

2016

(63) Utoyama M, Akieda-Asai S, Koda S, Nunoi H, Date Y: Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats. Neurosci Lett, 614:83-88 (2016)

2015

(62) Hasegawa K, Akieda-Asai S, Fujii Y, Yasuda M, Date Y: Guanylin-Guanylyl Cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet. Endocrine J 62(10):939-947 (2015)

(61) Hasegawa K, Akieda-Asai S, Date Y: Characterization of inflammatory gene expression and chemotaxis of macrophages guanylin and guanylyl cyclase-C. Am J Life Sci 3(3):43-47 (2015)

2014

(60) Bae CR, Hasegawa K, Akieda-Asai S, Kawasaki Y, Cha YS, Date Y: The short-term effects of soft pellets on lipogenesis and insulin sensitivity in rats. Prev Nutr Food Sci 19(3):164-169 (2014)

(59) Bae CR, Hasegawa K, Akieda-Asai S, Kawasaki Y, Senba K, Cha YS, Date Y: Possible involvement of food texture in insulin resistance and energy metabolism in male rats. J Endocrinol 222(1):61-72 (2014)

(58) Akieda-Asai S, Poleni PE, Date Y: Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus. Am J Physiol Endocrinol Metab 306(11):E1284-E1291(2014)

(57) Akieda-Asai S, Poleni PE, Hasegawa K, Date Y: Role of the neural pathway from hindbrain to hypothalamus in interaction of GLP1 and leptin in rats. J Endocrinol 220(2):109-116 (2014)

2013

(56) Senba K, Matsumoto T, Yamada K, Shiota S, Iha H, Date Y, Ohtsubo M, Nishizono A: Passive carriage of rabies virus by dendritic cells. Springerplus 2(1):419 (2013)

(55) Akieda-Asai S, Koda S, Sugiyama M, Furuya M, Miyazato M, Date Y: Metabolic features of rats resistant to a high-fat diet. Obes Res Clin Pract 7(4):e243-e250 (2013)

(54) Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y: Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to high-fat diet. J Lipid Res 54(1):85-96 (2013)

2012

(53) Date Y, Kangawa K: Ghrelin as a starvation signal. Obes Res Clin Pract 6(4):e263-e346 (2012)

(52) Poleni PE, Akieda-Asai S, Koda S, Sakurai M, Bae CR, Senba K, Cha YS, Furuya M, Date Y: Possible involvement of melanocortin-4-receptor and AMP-activated protein kinase in the interaction of glucagon-like peptide-1 and leptin on feeding in rats. Biochem Biophys Res Commun 420(1):36-41 (2012)

2011

(51) Mutoh E, Senba K, Akieda-Asai S, Miyashita A, Poleni PE, Date Y: Sex differences in energy metabolism in pre-pubescent, early pubescent and adult rats. Obes Res Clin Pract 5(2):e119-e128 (2011)

2010

(50) Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N: Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J Neurochem 114(4):1097-1106 (2010)

(49) Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M: Neuropeptide W: An anorectic peptide regulated by leptin and metabolic state. Endocrinology 151(5):2200-2210 (2010)

(48) Takenoya F, Yagi M, Kageyama H, Shiba K, Endo K, Nonaka N, Date Y, Nakazato M, Shioda S: Distribution of neuropeptide W in the rat brain. Neuropeptides 44(2):99-106 (2010)

2008

(47) Shibata M, Mondal MS, Date Y, Nakazato M, Suzuki H, Ueta Y: Distribution of orexins-containing fibers and contents of orexins in the rat olfactory bulb. Neurosci Res 61(1):99-105 (2008)

(46) Mondal MS, Yamaguchi H, Date Y, Tsuruta T, Shimbara T, Toshinai K, Shimomura Y, Mori M, Nakazato M: Ontogeny of a new enteric peptide, neuropeptide W (NPW), in the developing rat stomach. Regul Pept. 145(1-3):141-146 (2008)

(45) Takenoya F, Kitamura S, Kageyama H, Nonaka N, Seki M, Itabashi K, Date Y, Nakazato M, Shioda S: Neuronal interactions between neuropeptide W- and orexin- or melanin-concentrating hormone-containing neurons in the rat hypothalamus. Regul Pept 145(1-3):159-164 (2008)

2007

(44) Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, González LJ, Shioda S, Takao T, Nakazato M, Minamino N: Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2. J Biol Chem 282(36):26354-26360 (2007)

2006

(43) Ishimoto H, Mukae H, Date Y, Shimbara T, Mondal MS, Ashitani J, Hiratsuka T, Kubo S, Kohno S, Nakazato M: Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia. Eur Respir J 27(2):253-260 (2006)

(42) Sato M, Nakahara K, Goto S, Kaiya H, Miyazato M, Date Y, Nakazato M, Kangawa K, Murakami N: Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord. Biochem Biophys Res Commun 350(3):598-603 (2006)

(41) Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N, Miyazato M, Kokame K, Ishizuka Y, Ishida Y, Kageyama H, Shioda S, Kangawa K, Nakazato M: Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab 4(4):323-331 (2006)

(40) Toshinai K, Yamaguchi H, Sun Y, Smith RG, Yamanaka A, Sakurai T, Date Y, Mondal MS, Shimbara T, Kawagoe T, Murakami N, Miyazato M, Kangawa K, Nakazato M: Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 147(5): 2306-2314 (2006)

(39) Sawada H, Yamaguchi H, Shimbara T, Toshinai K, Mondal MS, Date Y, Murakami N, Katafuchi T, Minamino N, Nunoi H, Nakazato M: Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats. Endocrinology 147(4): 2043-2050 (2006)

(38) Nakahara K, Nakagawa M, Baba Y, Sato M, Toshinai K, Date Y, Nakazato M, Kojima M, Miyazato M, Kaiya H, Hosoda H, Kangawa K, Murakami N: Maternal ghrelin plays an important role in rat fetal development during pregnancy. Endocrinology 147(3):1333-1342 (2006)

(37) Mondal MS, Kawagoe T, Yamaguchi H, Date Y, Kawagoe T, Tsuruta T, Kageyama H, Kawamura Y, Shioda S, Shimomura Y, Mori M, Nakazato M: Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. J Endocrinol 188(1):49-57 (2006)

2005

(36) Yanagi S, Ashitani J, Ishimoto H, Date Y, Mukae H, Chino N, Nakazato M: Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection. Respir Res 6(1):130 (2005)

(35) Date Y, Toshinai K, Koda S, Miyazato M, Shimbara T, Tsuruta T, Niijima A, Kangawa K, Nakazato M: Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 146(8): 3518-3525 (2005)

(34) Koda S, Date Y, Murakami N, Shimbara T, Hanada T, Toshinai K, Niijima A, Furuya M, Inomata N, Osuye K, Nakazato M: The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146(5): 2369-2375 (2005)

(33) Mondal MS, Date Y, Yamaguchi H, Toshinai K, Kangawa K, Nakazato M: Identification of ghrelin neurons and its receptor, GHS-R, in rat brain. Regul Pept 126(1-2): 55-59 (2005)

2004

(32) Isomoto H, Mukae H, Ishimoto H, Date Y, Nishi Y, Inoue K, Wada A, Hirayama T, Nakazato M, KohnoS: Elevated concentrations of alpha-defensins in gastric juice of patients with Helicobacter pylori infection. Am J Gastroenterol 99(10): 1916-1923 (2004)

(31) Hanada T, Toshinai K, Date Y, Kajimura N, Tsukada T, Hayashi Y, Kangawa K, Nakazato M: Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells. Metabolism 53(1):84-88 (2004)

2003

(30) Hanada T, Date Y, Shimbara T, Sakihara S, Murakami N, Hayashi Y, Kanai Y, Suda T, Kangawa K, Nakazato M: Central actions of neuromedin U via corticotropin-releasing hormone. Biochem Biophys Res Commun 311(4):954-958 (2003)

(29) Mondal MS, Yamaguchi H, Date Y, Shimbara T, Toshinai K, Shimomura Y, Mori M, Nakazato M: A role for neuropeptide W in the regulation of feeding behavior. Endocrinology 144(11):4729-4733 (2003)

(28) Mondal MS, Date Y, Murakami N, Toshinai K, Shimbara T, Kangawa K, Nakazato M: Neuromedin U acts in the central nervous system to inhibit gastric acid secretion via corticotropin-releasing hormone system. Am J Physiol 284:G963-G969 (2003)

(27) Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M: Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 144:1506-1512 (2003)

2002

(26) Date Y, Murakami N, Toshinai K, Matsukura S, Nijima A, Matsuo H, Kangawa K, Nakazato M: The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion. Gastroenterology 123(4):1120-1128 (2002)

(25) Hayashida T, Nakahara K, Mondal MS, Date Y, Nakazato M, Kojima M, Kangawa K, Murakami N: Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 173(2):239-245 (2002)

(24) Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S: Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87(1):240-244 (2002)

(23) Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Kojima M, Kangawa K, Arima T, Yada T, Matsuo H, Matsukura S: Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion. Diabetes 51(1):124-129 (2002)

2001

(22) Hiratsuka T, Nakazato M, Date Y, Mukae H, Matsukura S: Nucleotide sequence and expression of rat beta-defensin-1: its significance in diabetic rodent models. Nephron 88(1):65-70 (2001)

(21) Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature 409(6817):194-198 (2001)

(20) Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S: Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280(3):904-907 (2001)

2000

(19) Ashitani J, Nakazato M, Mukae H, Taniguchi H, Date Y, Matsukura S: Recombinant granulocyte colony-stimulating factor induces production of human neutrophil peptides in lung cancer patients with neutropenia. Regul Pept 95(1-3):87-92 (2000)

(18) Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M: Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 275(2):477-480 (2000)

(17) Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M: Ghrelin, a novel growth- hormone- releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141(11):4255-4261 (2000)

(16) Date Y, Mondal MS, Matsukura S, Ueta Y, Yamashita H, Kaiya H, Kangawa K, Nakazato M: Distribution of orexin/hypocretin in the rat median eminence and pituitary. Mol Brain Res 76(6):1-6 (2000)

(15) Date Y, Mondal MS, Matsukura S, Nakazato M: Distribution of orexin-A and orexin-B in the rat spinal cord. Neurosci Lett 288(2):87-90 (2000)

1999

(14) Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402(6762):656-660 (1999)

(13) Date Y, Nakazato M, Yamaguchi H, Kangawa K, Kinoshita Y, Chiba T, Ueta Y, Yamashita H, Matsukura S: Enterochromaffin-like cell, a cellular source of uroguanylin in rat stomach. Endocrinology 140(5):2398-2404 (1999)

(12) Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M: Orexins, novel orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 96(2):748-753 (1999)

1998

(11) Hiratsuka T, Nakazato M, Date Y, Ashitani J, Minematsu T, Chino N, Matsukura S: Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 249(3):943-947 (1998)

(10) Nakazato M, Yamaguchi H, Date Y, Kangawa K, Goy F.M, Chino N, Matsukura S: Tissue distribution, cellular source and structural analysis of rat immunoreactive uroguanylin. Endocrinology 139(12):5247-5254 (1998)

1997

(9) Kinoshita H, Fujimoto S, Nakazato M, Yokota N, Date Y, Yamaguchi H, Hisanaga S, Eto T: Plasma and urine levels of uroguanylin and its molecular forms in renal diseases. Kidney Int 52(4):1028-1034 (1997)

(8) Date Y, Nakazato M, Kangawa K, Shirieda K, Fujimoto T, Matsukura S: Detection of three transthyretin gene mutations in familial amyloidotic polyneuropathy by analysis of DNA extracted from formalin-fixed and paraffin-embedded tissues. J Neurol Sci 150(2):143-148 (1997)

1996

(7) Date Y, Nakazato M, Yamaguchi H, Miyazato M, Matsukura S: Tissue distribution and plasma concentration of human guanylin. Int Med 35(3):171-175 (1996)

(6) Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S: Cloning and characterization of a cDNA encoding a precursor for human uroguanylin. Biochem Biophys Res Commun 219(2):644-648 (1996)

1995

(5) Mukae H, Ashitani J, Nakazato M, Taniguchi H, Date Y, Ihi T, Shiomi K, Mashimoto H, Kadota J, Kohno S, et al: A study of defensins in bronchoalveolar lavage fluid in patients with diffuse panbronchiolitis. Kansenshogaku Zasshi 69(9):975-981 (1995)

(4) Nakazato M, Shiomi K, Date Y, Matsukura S, Kangawa K, Minamino N, Matsuo H: Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils. Biochem Biophys Res Commun 211(3):1053-1062 (1995)

(3) Nakazato M, Shiomi K, Date Y, Matsukura S, Kangawa K, Minamino N, Matsuo H: Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides form bone marrow, plasma and peripheral blood neutrophils. Biochem Biophys Res Commun 211(3):1053-1062 (1995)

1994

(2) Date Y, Nakazato M, Shiomi K, Toshimori H, Kangawa K, Matsuo H, Matsukura S: Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series. Ann Hematol　69(2):73-77 (1994)

(1) Nakazato M, Yamaguchi H, Shiomi K, Date Y, Fujimoto S, Kangawa K, Matsuo H, Matsukura S: Identification of 10-kDa proguanylin as a major guanylin molecule in human intestine and plasma and its increase in renal insufficiency. Biochem Biophys Res Commun 205(3):1966-1975 (1994)