Hot Topic: New insight into the RAMP-based Family B GPCRs and their peptide ligands

Editorial [The RAMP-interacting Family B G protein-coupled receptors and their specific bioactive peptides]
Kenji Kuwasako (Guest Editor)
Frontier Science Research Center, University of Miyazaki, Japan,

[Part 1] Calcitonin family peptides: AM, CGRP, AM2/Intermedin and amylin

1. Adrenomedullin as potential therapeutic agent for inflammatory bowel disease

   First author: Dr. Shinya Ashizuka
   Corresponding author: Prof. Kzauo Kitamura
   Division of Circulation and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan

2. Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application

   First and corresponding author: Dr. Toshio Nishikimi
   Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan

3. Antiinflammatory activities of CGRP modulating innate immune responses in health and disease

   Single author: Prof. Bernhard Holzmann
   Department of Surgery, Technische Universität München, Germany

4. Insulin resistance-induced hypertension and a role of perivascular CGRPergic nerves

   First and corresponding author: Dr. Shingo Takatori
   Department of Pharmaceutical Science, Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama
   University, Japan

5. Exploring new CGRP family peptides and their receptors in vertebrates

   First and corresponding author: Prof. Yoshio Takei
   Laboratory of Physiology, Department of Marine Bioscience, Atmosphere and Ocean Research Institute, University of
   Tokyo, Japan

6. Protective effects of Intermedin on cardiovascular, renal and pulmonary diseases:comparison with adrenomedullin and CGRP

   First author: Dr. Daivid Holmes
   Corresponding author: Dr. David Bell
   Therapeutic and Pharmacology, School of Medicine, Dentistry and Biomedical Sciences,
   The Queen’s University of Belfast, UK

7. Islet amyloid polypeptide and diabetes

   First author: Dr. Gunilla T. Westermark
   Corresponding author: Prof. Per Westermark
   Department of Immunology, Genetics and Pathology, Uppsala University, Sweden

8. Role of amylin and its receptors in neurodegeneration

   First author: Dr. Wen Fu
   Corresponding author: Prof. Jack H. Jhamandas
   Division of Neurology, Department of Medicine, Centres for Neuroscience and for Prions and Protein Folding Diseases, University of Alberta, Canada

[Part 2] RAMP-interacting Family B GPCRs

9. Regulation of adrenomedullin and its family peptides by RAMP system – Lessons from genetically engineered mice –

   First and corresponding author: Prof. Takayuki Shindo
   Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Japan

10. Comparing the molecular pharmacology of CGRP and adrenomedullin

    First author: Dr. Michael J Woolley
    Corresponding author: Dr. Alex C. Conner
    Warwick Medical School, University of Warwick, UK

11. Ectodomain structures of the CGRP and AM receptors

    First author: Dr. Seisuke Kusano
    Corresponding author: Prof. Shigeyuki Yokoyama
    RIKEN Systems and Structural Biology Center, Japan

12. CGRP receptor antagonism and migraine therapy

    First and corresponding author: Prof. Lars Edvinsson
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Sweden

13. Roles of CLR/RAMP receptor signaling in reproduction and development

    First and corresponding author: Dr. Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, 5 Fu-Shin Street, Kweishan, Taoyuan 333, Taiwan

14. Role of CGRP-receptor component protein (RCP) in CLR/RAMP function

    Single author: Dr. Ian M. Dickerson
    Department of Neurobiology & Anatomy, University of Rochester Medical Center, USA

15. Functions of third extracellular loop and heix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking

    First and corresponding author: Dr. Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, Japan

16. Is the cytoskeleton an intracellular receptor for adrenomedullin and PAMP?

    First author: Dr. Ignacio M. Larráyoz
    Corresponding author: Prof. Alfredo Martinez
    ngiogenesis Study Group, Oncology area, Center for Biomedical Research of La Rioja, Spain