Our laboratory focuses on the pathogenesis of thrombosis and atherosclerosis.
Thrombosis is the formation of a blood clot (thrombus). Thrombus may form in any part of the cardiovascular system, including arteries, veins the heart and the microcirculation. Arterial thrombi usually develop on the disrupted atherosclerotic lesions (atherothrombosis), causing myocardial infarction and ischemic stroke, etc. Venous thrombi usually occur in the lower limbs, which is a major cause of pulmonary thromboembolism. Thrombi are composed of fibrin and blood cells. However the mechanisms of thrombus formation and propagation remain unclear, because many factors, such as vessel wall constituents, local hemorheology, systemic thrombogenicity, also immune and inflammatory reactions, are involved in the process. We have studied the issue from the viewpoint of human and experimental pathology, and have elucidated the crucial role of vascular tissue factor and blood flow alteration.
Yujiro Asada, MD, PhD
Yuichiro Sato, MD, PhD (Division of Diagnostic Pathology, University Hospital)
Atsushi Yamashita, MD, PhD
Sayaka Moriguchi, MD, PhD (Division of Diagnostic Pathology, University Hospital)
Naoki Sameshima, MD, PhD
Division of Pathophysiology, Department of Pathology
Faculty of Medicine, University of Miyazaki
5200 Kihara, Kiyotake, Miyazaki, Miyazaki, Japan
E-mail: y\s\d\@med.miy\z\ki-u.\c.jp (change ‘\’ to ‘a’ before send your mail)