開催概要

研究内容

当教室の中里雅光教授が研究代表者として平成26年度から CRESTに採択されました。

CRESTは、「我が国の社会的・経済的ニーズの実現に向けた戦略目標に対して設定され、インパクトの大きなイノベーションシーズを創出するためのチーム型研究です。戦略創造事業のうち、全体の規模としては最大で、複数の山々がそびえ立つ八ヶ岳のように、１つの領域に強力な研究群団が並び立ち、国の政策実現に向け研究を推進します。」という理念の国家的なプロジェクトの一つであり、5.5年の長期研究計画になります。自治医科大学学長の永井良三先生が総括する「生体恒常性維持・変容・破綻機構のネットワーク的理解に基づく最適医療実現のための技術創出」領域で、宮崎大学農学部村上昇先生と国立循環器病研究センター研究所の宮里幹也部長との共同研究で「自律神経・ペプチド連関を基軸とするエネルギー代謝と免疫制御機構の解明」を研究課題として進めています。
　

業　績

【2017】

  1. Yanagi S, Sato T, Kangawa K, Nakazato M.: The homeostatic force of ghrelin. Cell Metab, 27: 786-804 (2018) doi: 10.1016/j.cmet.2018.02.008.

  2. Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.: Activation of AMPK-regulated CRH neurons in the PVH is sufficient and necessary to induce dietary preference for carbohydrate over fat. Cell Rep, 22: 706-721 (2018) doi: 10.1016/j.celrep.2017.11.102.

  3. Naznin F, Sakoda H, Okada T, Tsubouchi H, Waise TM, Arakawa K, Nakazato M.: Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice. Eur J Pharmacol, 794: 37-44 (2017) doi: 10.1016/j.ejphar.2016.11.028.

  4. Miki K, Maekura R, Nakazato M, Matsumoto N, Kitada S, Miki M, Yoshimura K, Mori M, Kangawa K.: Randomized, dose-finding trial of ghrelin treatment for chronic respiratory failure. Clin Respir J, 11: 496-505 (2017) doi: 10.1111/crj.12364.

  5. Ueno H, Shiiya T, Nagamine K, Tsuchimochi W, Sakoda H, Shiomi K, Kangawa K, Nakazato M.: Clinical application of ghrelin for diabetic peripheral neuropathy. Endocrine J, 64: S53-S57 (2017) doi: 10.1507/endocrj.64.S53.

  6. Tsubouchi H, Onomura H, Saito Y, Yanagi S, Miura A, Matsuo A, Matsumoto N, Nakazato M.: Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line. Endocrine J, 64: S41-S46 (2017) doi: 10.1507/endocrj.64.S41.

  7. Matsumoto N, Tsubouchi H, Imazu Y, Arimura Y, Yanagi S, Iiboshi H, Nakazato M. : Clinical application of ghrelin for chronic respiratory failure. Endocrine J, 64: S1-S3 (2017) doi: 10.1507/endocrj.64.S1.

  8. Ishii N, Mochizuki H, Sakai K, Shiomi K, Nakazato M. : Parkinsonism and high-intensity midbrain lesions on T2-weighted imaging in hepatic encephalopathy: a case report. Neurol Sci, 38: 1547-1549 (2017) doi: 10.1007/s10072-017-2976-8

  9. Yanagi S, Tsubouchi H, Miura A, Matsuo A, Matsumoto N, Nakazato M.: The impacts of cellular senescence in elderly pneumonia and in age-related lung disease that increase the risk of respiratory infections. Int J Mol Sci, 18: 503 (2017) doi: 10.3390/ijms18030503.

  10. Namkoong C, Toshinai K, Waise TM, Sakoda H, Sasaki K, Ueta Y, Kim MS, Minamino N, Nakazato M.: NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway. Biochem Biophys Res Commun, 485: 409-413 (2017) doi: 10.1016/j.bbrc.2017.02.064.

  11. Taniguchi A, Mochizuki H, Yamashita A, Shiomi K, Asada Y, Nakazato M.: Spinal cord anteroposterior atrophy in HAM/TSP: magnetic resonance imaging and neuropathological analyses. J Neurol Sci, 381: 135-140 (2017) doi: 10.1016/j.jns.2017.08.3243.

  12. Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, Takayama K, Hayashi Y, Nakazato M.: Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells. Biochem Biophys Res Commun, 493: 677-683 (2017) doi: 10.1016/j.bbrc.2017.08.132.

  13. Shimizu K, Yonekawa T, Yoshida M, Miyazato M, Miura A, Sakoda H, Yamaguchi H, Nakazato M.: Conformational Change in the Ligand-binding Pocket via a Novel KISS1R Mutation (P147L) Leads to Isolated GnRH Deficiency, J Endo Soc, 1: 1259-1271 (2017) doi: 10.1210/js.2017-00277.

  14. Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.: Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice. Eur J Pharmacol, 819: 35-42 (2017) doi: 10.1016/j.ejphar.2017.11.024.

  15. Naznin F, Toshinai K, Waise TM, Okada T, Sakoda H, Nakazato M.: Restoration of metabolic inflammation−related ghrelin resistance by weight loss. J Mol Endocrinol, 60: 109-118 (2017) doi: 10.1530/JME-17-0192.

  16. Miura K, Nojiri T, Akitake Y, Ando K, Fukuhara S, Zenitani M, Kimura T, Hino J, Miyazato M, Hosoda H, Kangawa K. CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading. Biochemical Journal. 2017, 474, 1897-1918, doi:10.1042/BCJ20160841.

  17. Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K. Overexpression of C-type natriuretic peptide in endothelial cells protects against insulin resistance and inflammation during diet-induced obesity. Scientific Reports. 2017, 7, 9807, doi:10.1038/s41598-017-10240-1.

  18. Mori K, Ida T, Fudetani M, Mori M, Kaiya H, Hino J, Nakahara K, Murakami N, Miyazato M, Kangawa K. Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release. Scientific Reports. 2017, 7, 10468, doi:10.1038/s41598-017-10319-9.

  19. Ensho T, Maruyama K, Mori K, Miyazato M, Kangawa K, Nakahara K, Murakami N. Neuromedin U precursor-related peptide (NURP) exerts neuromedin U-like sympathetic nerve action in the rat. Biochem Biophys Res Commun. 2017, 492, 412-418, doi:10.1016/j.bbrc.2017.08.084.

  20. Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, Takayama K, Hayashi Y, Nakazato M. Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic cells. Biochem Biophys Res Commun. 2017, 493, 677-683, doi:10.1016/j.bbrc.2017.08.132.

  21. Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, Hanada R, Kangawa K, Nakao K. Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice. Peptides. 2018, 99, 134-141, doi:10.1016/j.peptides.2017.09.011.

  22. Miyoshi T, Umekawa T, Hosoda H, Asada T, Fujiwara A, Kurosaki K, Shiraishi I, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N. Plasma natriuretic peptide levels in fetuses with congenital heart defect and arrhythmia: a single-center prospective study. Ultrasound in Obstetrics & Gynecology. 2017, doi:10.1002/uog.18925.

  23. Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y. Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes. Peptides. 2018, 99, 14-19, doi:10.1016/j.peptides.2017.10.012.

  24. Bae CR, Hino J, Hosoda H, Son C, Makino H, Tokudome T, Tomita T, Hosoda K, Miyazato M, Kangawa K. Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet. Scientific Reports. 2018, 8, 2093, doi:10.1038/s41598-018-20469-z.

  25. Ensho T, Nakahara K, Suzuki Y, Murakami N.: Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation. Neuropeptides, 65: 21-27 (2017)

  26. Suzuki Y, Nakahara K, Ensho T, Murakami N.: Sex difference of hyperinsulinemia in the C57BL/6J-Daruma (obese) mouse. Journal of veterinary Medical Science, 79: 1284-1293 (2017)

  27. Okamoto A, Nojiri T, Konishi K, Tokudome T, Miura K, Hosoda H, Hino J, Miyazato M, Kyomoto Y, Asai K, Hirata K, Kangawa K. Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice : ANP for pulmonary fibrosis. Respiratory Research, 18: 1 (2017)

  28. Hino J, Nakatani M, Arai Y, Tsuchida K, Shirai M, Miyazato M, Kangawa K. Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity. International Journal of Obesity. 41: 483-488 (2017)

【2016】
  1. Ueno H, Nakazato M. Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation. J Diabetes Investig. 2016, 7, 812-818 (2016)

  2. Ueno H, Nakazato M. Is ghrelin a glucagon-like peptide-1 secretagogue? J Diabetes Investig. 7: 466-467 (2016)

  3. Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H. Central insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor. Cell Rep. 14: 2362-2374 (2016)

  4. Mochizuki H, Taniguchi A, Nakazato Y, Ishii N, Ebihara Y, Sugiyama T, Shiomi K, Nakazato M. Increased body mass index associated with autonomic dysfunction in Parkinson's disease. Parkinsonism Relat Disord. 24: 129-31 (2016)

  5. Mochizuki H, Yagi K, Tsuruta K, Taniguchi A, Ishii N, Shiomi K, Nakazato M. Prolonged central sensory conduction time in patients with chronic arsenic exposure. J Neurol Sci. 361, 39-42 (2016)

  6. Tsubouchi H, Matsumoto N, Yanagi S, Arimura Y, Nakazato M. Successful treatment of sepsis due to Pantoea agglomerants by polymyxin B-immobilized fiber column direct hemoperfusion therapy in a small cell lung carcinoma patient. Respir Med Case Rep. 19: 155-158 (2016)

  7. Nojiri T, Hosoda H, Kimura T, Tokudome T, Miura K, Takabatake H, Miyazato M, Okumura M, Kangawa K. Protective effects of ghrelin on cisplatin-induced nephrotoxicity in mice. Peptides. 82: 85-91 (2016)

【2015】
  1. Kim JW, Rhee M, Park JH, Yamaguchi H, Sasaki K, Minamino N, Nakazato M, Song DK, Yoon KH.: Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic β-cells. Biochem Biophys Res Commun, 457: 148-153 (2015)

  2. Tsuchimochi W, Ueno H, Yamashita E, Tsubouchi C, Sakoda H, Nakamura S, Nakazato M.: Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients. Endocr J, 62: 13-20 (2015)

  3. Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K.: Ghrelin administration for chronic respiratory failure: a randomized dose-comparison trial. Lung, 193: 239-247 (2015)

  4. Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.: Ghrelin. Mol Metab, 4: 437-460 (2015)

  5. Kawaguchi M, Kanemaru A, Fukushima T, Yamamoto K, Tanaka H, Haruyama Y, Itoh H, Matsumoto N, Kangawa K, Nakazato M, Kataoka H.: Ghrelin administration suppresses inflammation-associated colorectal carcinogenesis in mice. Cancer Sci, 106: 1130-1136 (2015)

  6. Naznin F, Toshinai K, Waise TM, Namkoong C, Moin AS, Sakoda H, Nakazato M.: Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation. J Endocrinol, 226: 81-92 (2015)

  7. Waise TM, Toshinai K, Naznin F, NamKoong C, Md Moin AS, Sakoda H, Nakazato M.: One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice. Biochem Biophys Res Commun, 464: 1157-1162 (2015)

  8. Miki K, Maekura R, Nakazato M, Matsumoto N, Kitada S, Miki M, Yoshimura K, Mori M, Kangawa K.: Randomized, dose-finding trial of ghrelin treatment for chronic respiratory failure, Clin Respir J, 2015 Aug 10.

  9. Ueno H, Nakazato M.: The mechanistic relationship between the vagal afferent pathway, central nervous system, and peripheral organs in appetite regulation. J Diabetes Investig, 10.1111/jdi.12492

  10. Mao Y, Tokudome T, Kishimoto I, Otani K, Nishimura H, Yamaguchi O, Otsu K, Miyazato M, Kangawa K.: Endogenous ghrelin attenuates pressure overload-induced cardiac hypertrophy via a cholinergic anti- inflammatory pathway. Hypertension. 65: 1238-44 (2015)

  11. Okame R1, Nakahara K, Kato Y, Bannai M, Murakami N.: Comparison of amino acid profiles between rats subjected to forced running and voluntary running exercises. J Vet Med Sci. 77: 661-668 (2015) doi: 10.1292/jvms.15-0020. Epub 2015 Feb 10.

　

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