研 究  Research

研究業績
Publications

宮崎大学医学部解剖学講座 超微形態科学分野
Department of Anatomy, Ultrastructural Cell Biology
Faculty of Medicine, University of Miyazaki

【 英文原著・総説 】
Imazato, H., Takahashi, N., Hirakawa, Y., Yamaguchi, Y., Hiyoshi, M., Tajima, T., Chosa, E., Sawaguchi, A.: Three-dimensional fine structures in deep fascia revealed by combined use of cryo-fixed histochemistry and low-vacuum scanning microscopy.
Sci Rep. 13(1): 6352 (2023) Apr. doi: 10.1038/s41598-023-33479-3.
DOI: 10.1038/s41598-023-33479-3.

Shinkawa, N., Takahashi, N., Yano, K., Sawaguchi, A., Sonoda, A., Kakizaki, E., Yukawa, N.: A Suggested Mechanism for Green Discoloration of the Postmortem Brain.
Am J Forensic Med Pathol. 44(2): 132-135 (2023) Jun. doi: 10.1097/PAF.0000000000000822.
DOI: 10.1097/PAF.0000000000000822.

Imazato, H., Takahashi, N., Sawaguchi, A., Hirakawa, Y., Yamaguchi, Y., Hiyoshi, M., Tajima, T., Chosa, E.: Insertion sites of the muscles attached to the clavicle: a cadaveric study of the clavicle.
BMC Musculoskelet Disord. 24(1): 160 (2023) Mar. doi: 10.1186/s12891-023-06266-4.
DOI: 10.1186/s12891-023-06266-4.

Sugimoto, N., Nakamura, S., Shimizu, S., Shigemasa, A., Kanda, J., Matsuyama, N., Tanaka, M., Hayashi, T., Fuchizaki, A., Nogawa, M., Watanabe, N., Okamoto, S., Handa, M., Sawaguchi, A., Momose, D., Koh, K.R., Tani, Y., Takaori-Kondo, A., Eto, K.: Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial.
Blood Adv. 6(23): 6056-6069 (2022) Dec. doi: 10.1182/bloodadvances.2022008512.
DOI: 10.1182/bloodadvances.2022008512

Sugimoto, N., Kanda, J., Nakamura, S., Kitano, T., Hishizawa, M., Kondo, T., Shimizu, S., Shigemasa, A., Hirai, H., Arai, Y., Minami, M., Tada, H., Momose, D., Koh, K.R., Nogawa, M., Watanabe, N., Okamoto, S., Handa, M., Sawaguchi, A., Matsuyama, N., Tanaka, M., Hayashi, T., Fuchizaki, A., Tani, Y., Takaori-Kondo, A., Eto, K.: PLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study.
Blood 140(22): 2398-2402 (2022) Dec. doi: 10.1182/blood.2022017296.
DOI: 10.1182/blood.2022017296

Sone, M., Nakamura, S., Umeda, S., Ginya, H., Oshima, M., Kanashiro, M.A., Paul, S.K., Hashimoto, K., Nakamura, E., Harada, Y., Tsujimura, K., Saraya, A., Yamaguchi, T., Sugimoto, N., Sawaguchi, A., Iwama, A., Eto, K., Takayama, N.: Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs.
Stem Cell Reports 16(12):2861-2870 (2021) Dec. doi: 10.1016/j.stemcr.2021.11.001.
DOI: 10.1016/j.stemcr.2021.11.001

Sawaguchi, A., Kamimura, T., Takahashi, N., Yamashita, A., Asada, Y., Imazato, H., Aoyama, F., Wakui, A., Sato, T., Choijookhuu, N., Hishikawa, Y.: In situ strategy for biomedical target localization via nanogold nucleation and secondary growth.
Commun Biol. 4(1):710, 2021 doi: 10.1038/s42003-021-02246-3.
DOI: 10.1038/s42003-021-02246-3

Fujii, T., Shimizu, T., Katoh, M., Nagamori, S., Koizumi, K., Fukuoka, J., Tabuchi, Y., Sawaguchi, A., Okumura, T., Shibuya, K., Fujii, T., Takeshima, H., Sakai, H.: Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase.
iScience. 24(5): 102412, 2021 doi: 10.1016/j.isci.2021.102412.
DOI: 10.1016/j.isci.2021.102412

Takahashi, N., Aoyama, F., Sawaguchi, A.: Three-dimensional culture of a pancreatic cancer cell line, SUIT-58, with air exposure can reflect the intrinsic features of the original tumor through electron microscopy.
Microscopy. 70(2): 192-200, 2021 doi: 10.1093/jmicro/dfaa046.
DOI: 10.1093/jmicro/dfaa046

Ozono, Y., Shide, K., Kameda, T., Kamiunten, A., Tahira, Y., Sekine, M., Akizuki, K., Nakamura, K., Iwakiri, H., Sueta, M., Hidaka, T., Kubuki, Y., Yamamoto, S., Hasuike, S., Sawaguchi, A., Nagata, K., Shimoda, K.: Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice.
Leukemia 35(2): 454-467, 2021 doi: 10.1038/s41375-020-0880-3.
DOI: 10.1038/s41375-020-0880-3

Suzuki, D., Flahou, C., Yoshikawa, N., Stirblyte, I., Hayashi, Y., Sawaguchi, A., Akasaka, M., Nakamura, S., Higashi, N., Xu, H., Matsumoto, T., Fujio, K., Manz, M.G., Hotta, A., Takizawa, H., Eto, K., Sugimoto, N.: iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.
Stem Cell Reports, 14(1): 49-59, 2020
DOI: 10.1016/j.stemcr.2019.11.011

Tin Htwe Kyaw, M., Yamaguchi, Y., Choijookhuu, N., Yano, K., Takagi, H., Takahashi, N., Oo, P.S., Sato, K., Hishikawa, Y.: The HDAC Inhibitor, SAHA, Combined with Cisplatin Synergistically Induces Apoptosis in Alpha-fetoprotein-producing Hepatoid Adenocarcinoma Cells.
Acta Histochem Cytochem, 52(1):1-8, 2019 doi: 10.1267/ahc.18044
DOI: 10.1267/ahc.18044

Ozono, Y., Shide, K., Toyoshima, F., Takaishi, Y., Tsuchimochi, M., Kamiunten, A., Kameda, T., Nakamura, K., Miike, T., Kusumoto, K., Iwakiri, H., Hasuike, S., Nagata, K., Sawaguchi, A., Shimoda, K.: Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis.
Hepatobiliary Pancreat Dis Int, S1499-3872(19) 30029-3, 2019
DOI: 10.1016/j.hbpd.2019.02.002

Seo, H., Chen, S.J., Hashimoto, K., Endo, H., Nishi, Y., Ohta, A., Yamamoto, T., Hotta, A., Sawaguchi , A., Hayashi, H., Koseki, N., Murphy, G.J., Fukuda, K., Sugimoto, N., Eto, K.: A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.
Blood Adv, 2: 2262-2272, 2018
PMCID: PMC6134216

Ito, Y., Nakamura, S., Sugimoto, N., Shigemori, T., Kato, Y., Ohno, M., Sakuma, S., Ito, K., Kumon, H., Hirose, H., Okamoto, H., Nogawa, M., Iwasaki, M., Kihara, S., Fujio, K., Matsumoto, T., Higashi, N., Hashimoto, K., Sawaguchi, A., Harimoto, K.I., Nakagawa, M., Yamamoto, T., Handa, M., Watanabe, N., Nishi, E., Arai, F., Nishimura, S., Eto, K.: Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
Cell, 174(3): 636-648, 2018
DOI: 10.1016/j.cell.2018.06.011

Sawaguchi, A., Kamimura, T., Yamashita, A., Takahashi, N., Ichikawa, K., Aoyama, F., Asada, Y.: Informative three-dimensional survey of cell/tissue architectures in thick paraffin sections by simple low-vacuum scanning electron microscopy.
Sci Rep, 8(1): 7479. doi: 10.1038/s41598-018-25840-8, 2018
DOI: 10.1038/s41598-018-25840-8

Oo, P.S., Yamaguchi, Y., Sawaguchi, A., Tin Htwe Kyaw, M., Choijookhuu, N., Noor Ali, M., Srisowanna, N., Hino, S.I., Hishikawa, Y.: Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells.
Acta Histochem Cytochem, 51(1): 21-31, 2018
PMCID: PMC5880800

Shide, K., Kameda, T., Yamaji, T., Sekine, M., Inada, N., Kamiunten, A., Akizuki, K., Nakamura, K., Hidaka, T., Kubuki, Y., Shimoda, H., Kitanaka, A., Honda, A., Sawaguchi, A., Abe, H., Miike, T., Iwakiri, H., Tahara, Y., Sueta, M., Hasuike, S., Yamamoto, S., Nagata, K., Shimoda, K.: Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib
Leukemia, 31(5): 1136-1144, 2017
DOI: 10.1038/leu.2016.308

Hirata, S., Murata, T., Suzuki, D., Nakamura, S., Jono-Ohnishi, R., Hirose, H., Sawaguchi, A., Nishimura, S., Sugimoto, N., Eto, K.: Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.
Stem Cells Transl Med, 6 (3): 720 -730, 2017
DOI: 10.5966/sctm.2016-0104

Aihara, A., Koike, T., Abe, N., Nakamura, S., Sawaguchi, A., Nakamura, T., Sugimoto, N., Nakauchi, H., Nishino, T., Eto, K.: Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells.
Blood Adv, 1: 468-476, 2017
PMCID: PMC5738977

Mondal, S.I., Islam, M.R., Sawaguchi, A., Asadulghani, M., Ooka, T., Gotoh, Y., Kasahara, Y., Ogura, Y., Hayashi, T.: Genes essential for the morphogenesis of the Shiga toxin 2-transducing phage from Escherichia coli O157:H7.
Sci Rep, 6: 39036, 2016
DOI: 10.1038/srep39036

Zhao, C., Ichimura, A., Qian, N., Iida, T., Yamazaki, D., Noma, N., Asagiri, M., Yamamoto, K., Komazaki, S., Sato, C., Aoyama, F., Sawaguchi, A., Kakizawa, S., Nishi, M., Takeshima, H.: Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.
Sci Signal, 9 (428): ra49, 2016
DOI: 10.1126/scisignal.aad9055

Onishi, J., Sato, Y., Sawaguchi, A., Yamashita, A., Maekawa, K., Sameshima, H., Asada, Y.: Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Hum Pathol, 55: 174-81, 2016
DOI: 10.1016/j.humpath.2016.05.007

Takahashi, N., Aoyama, F., Ohuchida, J., Sameshima, N., Asada, Y., Sawaguchi, A.: Establishment and characterization of SUIT-58 pancreas cancer cell line and its subline S58-SF adapted to serum-free condition derived from metastatic liver tumor.
Hum Cell, 28 (4): 190-198, 2015
DOI: 10.1007/s13577-015-0122-6

Nishimura, S., Nagasaki, M., Kunishima, S., Sawaguchi, A., Sakata, A., Sakaguchi, H., Ohmori, T., Manabe, I., Italiano, J.E. Jr, Ryu, T., Takayama, N., Komuro, I., Kadowaki, T., Eto, K., Nagai, R.: IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.
J Cell Biol, 209(3): 453-66, 2015
DOI: 10.1083/jcb.201410052

Kawaguchi, M., Kanemaru, A., Sawaguchi, A., Yamamoto, K., Baba, T., Lin, C.Y., Johnson, M.D., Fukushima, T., Kataoka, H.: Hepatocyte Growth Factor Activator Inhibitor Type 1 Maintains the Assembly of Keratin into Desmosomes in Keratinocytes by Regulating Protease-Activated Receptor 2-Dependent p38 Signaling.
Am J Pathol, 185: 1610-1623, 2015
DOI: 10.1016/j.ajpath.2015.02.009

Miyauchi, S., Umekitga, K., Hidaka, T., Umeki, K., Aratake, Y., Takahashi, N., Sawaguchi, A., Nakatake, A., Morinaga, I., Morishita, K., Okayama, A.: Increased plasma lactoferrin levels in leucocytapheresis therapy in patients with rheumatoid arthritis
Rheumatol, 53: 1966-1972, 2014
DOI: 10.1093/rheumatology/keu219

Toshima, J.Y., Nishinoaki, S., Sato, Y., Yamamoto, W., Furukawa, D., Siekhaus, D.E., Sawaguchi, A., Toshima, J.: Bifurcation of the endocytic pathway into Rab5 dependent and independent transport to the vacuole.
Nature Commun, 5: 3498. doi: 10.1038/ncomms4498, 2014
DOI: 10.1038/ncomms4498

Nakamura, S., Takayama, N., Hirata, S., Seo, H., Endo, H., Ochi, K., Fujita, K., Koike, T., Harimoto, K., Dohda, T., Watanabe, A., Okita, K., Takahashi, N., Sawaguchi, A., Yamanaka, S., Nakauchi, H., Nishimura, S., Eto, K.: Expandable megakaryocyte cell lines enable clinically-applicable generation of platelets from human induced pluripotent stem cells.
Cell Stem Cell, 14(4): 535-548, 2014
DOI: 10.1016/j.stem.2014.01.011

Takahashi, N., Aoyama, F., Hiyoshi, M., Kataoka, H., Sawaguchi, A.: Establishment and biological characterization of a novel cell line derived from hepatoid adenocarcinoma originated at the ampulla of Vater.
J Int Oncol, 44: 1139-45, 2014
DOI: 10.3892/ijo.2014.2282

Nemoto, T., Toyoshima-Aoyama, F., Yanagita, T., Maruta, T., Fujita, H., Koshida, T., Yonaha, T., Wada, A., Sawaguchi, A., Murakami, M.: New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: Amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β.
Cell Signal, 26(2): 253-259, 2014
DOI: 10.1016/j.cellsig.2013.11.017

Hirose, S., Takayama, N., Nakamura, S., Nagasawa, K., Ochi, K., Hirata, S., Yamazaki, S., Yamaguchi, T., Otsu, M., Sano, S., Takahashi, N., Sawaguchi, A., Ito, M., Kato, T., Nakauchi, H., Eto, K.: Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells.
Stem Cell Reports, Dec 5;1(6):499-508, 2013. doi: 10.1016/j.stemcr.2013.10.010.
DOI: 10.1016/j.stemcr.2013.10.010

Nemoto, T., Toyoshima-Aoyama, F., Ueda, Y., Ohba, T., Yanagita, T., Watanabe, H., Shirasaka, T., Tsuneyoshi, I., Ishida, Y., Hirota, K., Sawaguchi, A., Murakami, M.:Involvement of the orexin system in adrenal sympathetic regulation.
Pharmacology, 91(5-6) : 250-258, 2013
DOI: 10.1159/000350391

Akieda-Asai, S., Sugiyama, M., Miyazawa, T., Koda, S., Okano, I., Senba, K., Poleni, P.E., Hizukuri, Y., Okamoto, A., Yamahara, K., Mutoh, E., Aoyama, F., Sawaguchi, A., Furuya, M., Miyazato, M., Kangawa, K., Date, Y.: Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to high-fat diet.
J Lipid Res, 54(1): 85-96, 2013
PMCID: PMC3520543

Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Van, B., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A., Takeshima, H.: TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells.
J Bioll Chem, 287(40): 33523-32, 2012
PMCID: PMC3460453

Kuroki, M., Nakada, H., Yamashita, A., Sawaguchi, A., Uchino, N., Sato, S., Asanuma, T., Asada, Y., Tamura, S.: Loss of cellular viability in areas of ground-glass opacity on computed tomography images immediately after pulmonary radiofrequency ablation in rabbits.
Jap J Radiol, 30: 323-330, 2012
DOI: 10.1007/s11604-012-0054-y

Tajiri, S., Fukui, T., Sawaguchi, A., Yoshinaga, K.: Cell- and region-specific expression of sugar chains in the mouse epididymal epithelium using lectin histochemistry combined with immunohistochemistry.
Okajimas Folia Anatomica Japonica, 88: 141-146, 2012
DOI: 10.2535/ofaj.88.141

Tajiri, S., Fukui, T., Sawaguchi, A., Yoshinaga, K.: Changes in lectin-binding sites on epididymal cells during postnatal development of the muse.
Okajimas Folia Anatomica Japonica, 88: 153-157, 2012
DOI: 10.2535/ofaj.88.153

Ohta, K., Higashi, R., Sawaguchi, A., Nakamura, KI.: Helical arrangement of filaments in microvillar actin bundles.
J Struc Biol, 177: 513-519, 2012
DOI: 10.1016/j.jsb.2011.10.012

Kawaguchi, M., Takeda, N., Hoshiko, S., Yorita, K., Baba, T., Sawaguchi, A., Nezu, Y., Yoshikawa, T., Fukushima, T., Kataoka, H.: Membrane-bound serine protease inhibitor HAI-1 is required for maintenance of intestinal epithelial integrity.
Am J Pathol, 179: 1815-1826, 2011
DOI: 10.1016/j.ajpath.2011.06.038

Aoyama, F., Sawaguchi, A.: Functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters in the apical canalicular membrane associated with acid secretion.
Biol Pharm Bull 34: 813-816, 2011
DOI: 10.1248/bpb.34.813

Yoshida, A., Nagayasu, E., Nishimaki, A., Sawaguchi, A., Yanagawa, S., Maruyama, H.: Transcripts analysis of infective larvae of an intestinal nematode, Stongyloides venezuelensis.
Parasitol Int 60: 75-83, 2011
DOI: 10.1016/j.parint.2010.10.007

Takayama, N., Nishimura, S., Nakamura, S., Shimizu, T., Ohnishi, R., Endo, H., Yamaguchi, T., Otsu, M., Nishimura, K., Nakanishi, M., Sawaguchi, A., Nagai, R., Takahashi, K., Yamanaka, S., Nakauchi, H., Eto, K.: Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
J Exp Med 207: 2817-2830, 2010
DOI: 10.1084/jem.20100844

Sawaguchi, A.: Immunoelectron microscopy of cryofixed freeze substituted mammalian tissue culture cells.
Methods in Molecular Biology. 657: 181-190, 2010
DOI: 10.1007/978-1-60761-783-9_14

Takizawa, H., Nishimura, S., Takayama, N., Oda, A., Nishikii, H., Morita, Y., Kakinuma, S., Yamazaki, S., Okamura, S., Tamura, N., Goto, S., Sawaguchi, A., Manabe, I., Takatsu, K., Nakauchi, H., Takaki, S., Eto, K.: Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo.
J Clin Invest 120: 179-190, 2010
DOI: 10.1172/JCI39503

Asadulghani, M., Ogura, Y., Ooka, T., Itoh, T., Sawaguchi, A., Iguchi, A., Nakayama, K., Hayashi, T.: The defective prophage pool of Escherichia coli O157: prophage-prophage interaction potentiate horizontal transfer of virulence determinants.
PLoS Pathog, 5: e1000408, 2009
DOI: 10.1371/journal.ppat.1000408

Sawaguchi, A., Aoyama, F., Ide S., Suganuma, T.: Capsule-supporting ring: a new device for resin embedding of glass-mounted specimens.
J Microsc, 234: 113-117, 2009
DOI: 10.1111/j.1365-2818.2009.03161.x

Umekita, K., Hidaka, T., Ueno, S., Takajo, I., Kai, Y., Nagatomo, Y., Sawaguchi, A., Suganuma, T., Okayama, A.: Leukocytapheresis (LCAP) decreases the level of platelet-derived microparticles (MPs) and increases the level of granulocytes-derived MPs: a possible connection with the effect of LCAP on rheumatoid arthritis.
Mod Rheumatol, 19(3) 265-272, 2009
DOI: 10.1007/s10165-009-0164-2

Huang, L., Adachi, T., Shimizu, Y., Goto, Y., Toyama, J., Tanaka, H., Akashi, R., Sawaguchi, A., Iwata, H., Haga, T.: Characterization of lectin isolated from Momordica charantia seed as a B cell activator.
Immunol. Lett, 121:148-156, 2008
DOI: 10.1016/j.imlet.2008.10.004

Sawaguchi, A., Aoyama, F., Ide S., Goto, Y., Suganuma, T.: A new device for high-pressure freezing of cultured cell monolayer using 10 µm-thin stainless discs as both culture plate and specimen carrier.
J Electron Mircosc 57: 203-206, 2008
DOI: 10.1093/jmicro/dfn020

Nagaike, K., Kawaguchi, M., Takeda, N., Fukushima, T., Sawaguchi, A., Hohama, K., Setoyama, M., Kataoka, H.: Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condiction and abnormal hair development in mice.
Am J Pathol 173: 1464-1475, 2008
DOI: 10.2353/ajpath.2008.071142

Nishikii, H., Eto, K., Tamura, N., Hattori, K., Heissig, B., Kanaji, T., Sawaguchi, A., Goto, S., Ware, J., Nakauchi, H.: Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.
J Exp Med 205: 1917-1927, 2008
DOI: 10.1084/jem.20071482

Takayama, N.,Nishikii, H., Usui, J., Tsukui, H., Sawaguchi, A., Hiroyama, T., Eto, K., Nakauchi, H.: Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.
Blood 111: 5298-5306, 2008
DOI: 10.1182/blood-2007-10-117622

Aoyama, F., Sawaguchi, A., Ide, S., Kitamura, K., Suganuma, T.: Exfoliation of gastric pit-parietal cells into the gastric lumen associated with a stimulation of isolated rat gastric mucosa in vitro: a morphological study by the application of cryotechniques.
Histochem Cell Biol 129: 785-793, 2008
DOI: 10.1007/s00418-008-0403-1

Ohashi, M., Ide, S., Sawaguchi, A., Kimitsuki, T., Komune, S., Suganuma, T.: Histochemical localization of the extracellular matrix components in the annular ligament of rat stapediovestibular joint with special reference to fibrillin, 36-kD microfibril-associated glycoprotein (MAGP-36), and hyaluronic acid.
Med Mol Morphol 41: 28-33, 2008
DOI: 10.1007/s00795-007-0394-3

Tsubokawa, D., Goso, Y., Sawaguchi, A., Kurihara, M., Ichikawa, T., Sato, M., Suganuma, T., Hotta, K., Ishihara, K.: An anti-mucin monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen on the carbohydrate moiety of mucin: Analysis of the epitope sequence and immunohistochemical study.
FEBS Journal 274: 1833-1848, 2007
DOI: 10.1111/j.1742-4658.2007.05731.x

Sawaguchi, A., Aoyama, F., Ohashi, M., Ide S., Suganuma, T.: Ultrastructural transformation of gastric parietal cells reverting from the active to the resting state of acid secretion revealed in isolated rat gastric mucosa model processed by high-pressure freezing.
J Electron Microsc 55: 97-105, 2006
DOI: 10.1093/jmicro/dfl004

Ohashi, M., Sawaguchi, A., Ide, S., Kimitsuki, T., Komune, S., Suganuma, T.: Histochemical characterization of the rat ossicular joint cartilage with a special reference to stapediovestibular joint.
Acta Histochem Cytochem 38: 387-392, 2005

Sawaguchi, A., Aoyama, F., Ide, S., Suganuma, T.: The cryofixation of isolated rat gastric mucosa provides new insights into the functional transformation of gastric parietal cells: an in vitro experimental model study.
Arch Histol Cytol 68: 151-160, 2005
DOI: 10.1679/aohc.68.151

Inagaki-Ohara, K., Sawaguchi, A., Suganuma, T., Matsuzaki, G., Nawa, Y.: Intraepithelial lymphocytes express junctional molecules in murine small intestine.
Biochem and Biophys Res Comm, 331: 977-983, 2005
DOI: 10.1016/j.bbrc.2005.04.025

Sawaguchi, A., Ide, S., Suganuma, T.: Application of 10-µm thin stainless foil to a new assembly of the specimen carrier in high pressure freezing.
J Electron Microsc, 54: 143-146, 2005
DOI: 10.1093/jmicro/dfi023

Nagaike, R., Sawaguchi, A., Kawano, J., Aoyama, F., Oinuma, T., Suganuma, T.: Regeneration of gastric mucosa during ulcer healing follows pathways that correspond to the ontogenetic course of rat fundic glands.
Virchows Arch, 445: 580-588, 2004
DOI: 10.1007/s00428-004-1134-x

Sawaguchi, A., McDonald, K.L., Forte, J.G.: High-pressure freezing of isolated gastric glands provides new insight into the fine structure and subcellular localization of H+/K+-ATPase in gastric parietal cells.
J Histochem Cytochem, 52: 77-86, 2004
DOI: 10.1177/002215540405200108

Sawaguchi, A., Yao, X., Forte, J.G., McDonald, K.L.: Direct attachment of cell suspensions to high pressure freezing specimen planchettes.
J Microsc 212: 13-20, 2003
DOI: 10.1046/j.1365-2818.2003.01225.x

Sawaguchi, A., McDonald, K.L., Karvar, S., Forte, J.G.: A new approach for high-pressure freezing of primary culture cells: the fine structure and stimulation-associated transformation of cultured rabbit gastric parietal cells.
J Microsc 208: 158-166, 2002
DOI: 10.1046/j.1365-2818.2002.01085.x

Yuchi, H., Suganuma, T., Sawaguchi, A., Ide, S., Kawano, J., Aoki, T., Kitamura, K., Eto, T.: Cryofixation processing is an excellent method to improve the retention of adrenomedullin antigenicity.
Histochem Cell Biol 118: 259-265, 2002
DOI: 10.1007/s00418-002-0431-1

Sawaguchi, A., Ishihara, K., Kawano, J., Oinuma, T., Hotta, K., Suganuma, T.: Fluid dynamics of the excretory flow of zymogenic and mucin contents in rat gastric gland processed by high pressure freezing/freeze substitution.
J Histochem Cytochem 50: 223-234, 2002
DOI: 10.1177/002215540205000210

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