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1\uff1a\u96e3\u6cbb\u6027\u611f\u67d3\u75c7\u306e\u514b\u670d\u3092\u76ee\u6307\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a<\/h4>\n\n\n\n

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2\uff1a\u5fae\u5c0f\u74b0\u5883\u306e\u30ed\u30fc\u30eb\u30d7\u30ec\u30a4\u30e4\u30fc\u306b\u7740\u76ee\u3057\u305f\u80ba\u304c\u3093\u3068\u96e3\u6cbb\u6027\u547c\u5438\u5668\u75be\u60a3\u306e\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/h4>\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

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3\uff1a\u5185\u5206\u6ccc\u7684\u6052\u5e38\u6027\u306e\u7834\u7dbb\u306b\u7740\u773c\u3057\u305f\u547c\u5438\u5668\u75be\u60a3\u3078\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/h4>\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

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\u81a0\u539f\u75c5\u5185\u79d1<\/h3>\n\n\n\n

1\uff1aHTLV-1\u611f\u67d3\u3068\u81a0\u539f\u75c5\u30ea\u30a6\u30de\u30c1\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e<\/h4>\n\n\n\n

HTLV-1\uff08\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b\uff09\u306fATL\uff08\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\uff09\u3084HAM\uff08HTLV-1\u95a2\u9023\u810a\u9ac4\u708e\uff09\u306e\u539f\u56e0\u3068\u306a\u308a\u3001\u4e5d\u5dde\u30fb\u6c96\u7e04\u5730\u65b9\u306b\u611f\u67d3\u8005\u304c\u591a\u3044\u3053\u3068\u3067\u77e5\u3089\u308c\u307e\u3059\u304c\u3001\u8fd1\u5e74\u3067\u306f\u5927\u90fd\u5e02\u570f\u3067\u3082\u611f\u67d3\u8005\u6570\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u904e\u53bb\u306e\u79c1\u9054\u306e\u7814\u7a76\u6210\u679c\u3067\u3001HTLV-1\u611f\u67d3\u304c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u708e\u75c7\u75c5\u614b\u3092\u5897\u60aa\u3055\u305b\u6cbb\u7642\u62b5\u6297\u6027\u3068\u306a\u308b\u3053\u3068\u3084\u3001\u5165\u9662\u3092\u8981\u3059\u308b\u611f\u67d3\u75c7\u306e\u5408\u4f75\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u6a5f\u5e8f\u306f\u672a\u3060\u306b\u4e0d\u660e\u3067\u3042\u308a\u3001\u6297\u30ea\u30a6\u30de\u30c1\u7642\u6cd5\u304cHTLV-1\u611f\u67d3\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3084ATL\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u306e\u304b\u3001\u306a\u3069\u306e\u7591\u554f\u3082\u89e3\u660e\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u3088\u308a\u591a\u6570\u306e\u75c7\u4f8b\u3067\u306e\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u30012020\u5e74\u304b\u3089\u306fAMED\u304c\u63a8\u9032\u3059\u308b\u96e3\u75c5\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u30012012\u5e74\u304b\u3089\u904b\u55b6\u3057\u3066\u304d\u305fHTLV-1\u967d\u6027\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u304c\u9023\u7d50\u3055\u308c\u3001\u4e5d\u5dde\u3092\u4e2d\u5fc3\u306b\u5168\u56fd\u306e\u533b\u7642\u6a5f\u95a2\u3068\u9023\u643a\u3057\u305f\u591a\u65bd\u8a2d\u5171\u540c\u30ec\u30b8\u30b9\u30c8\u30ea\u7814\u7a76\u304c\u30b9\u30bf\u30fc\u30c8\u3057\u3066\u3044\u307e\u3059\u3002\u30ec\u30b8\u30b9\u30c8\u30ea\u3078\u767b\u9332\u3055\u308c\u305f\u611f\u67d3\u8005\u306e\u65b9\u306e\u672b\u68a2\u8840\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30fc\u30bf\u30fc\u3067\u89e3\u6790\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u72b6\u6cc1\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3082\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u3066\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3092\u3082\u3068\u306b\u3001HTLV-1\u611f\u67d3\u3068\u81ea\u5df1\u514d\u75ab\u306e\u95a2\u9023\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306b\u8ca2\u732e\u3059\u308b\u305f\u3081\u3001\u57fa\u790e\u7814\u7a76\u30fb\u81e8\u5e8a\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u300cHTLV-1\u967d\u6027\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\u8a3a\u7642\u306e\u624b\u5f15\u304d\u300d\u306e\u4f5c\u6210\u3082\u884c\u306a\u3063\u3066\u304a\u308a\u3001\u533b\u7642\u95a2\u4fc2\u8005\u3084\u60a3\u8005\u69d8\u304c\u3044\u3064\u3067\u3082\u95b2\u89a7\u3067\u304d\u308b\u3088\u3046\u306b\u516c\u958b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

2\uff1a\u81ea\u5df1\u514d\u75ab\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u306b\u304a\u3051\u308b\u81ea\u5df1\u6297\u4f53\u3068\u81e8\u5e8a\u7684\u7279\u5fb4\u306e\u89e3\u660e<\/h4>\n\n\n\n

\u76ae\u819a\u7b4b\u708e\u30fb\u591a\u767a\u6027\u7b4b\u708e\u3092\u542b\u3080\u81ea\u5df1\u514d\u75ab\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u3067\u306f\u3001\u967d\u6027\u3068\u306a\u308b\u75be\u60a3\u7279\u7570\u7684\u81ea\u5df1\u6297\u4f53\u306b\u3088\u3063\u3066\u81e8\u5e8a\u7684\u75c5\u578b\u3084\u4e88\u5f8c\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6297SRP\u6297\u4f53\u967d\u6027\u58ca\u6b7b\u6027\u7b4b\u75c7\u306a\u3069\u306e\u7a00\u306a\u75be\u60a3\u306b\u95a2\u3057\u3066\u306f\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5c11\u306a\u304f\u3001\u4e0d\u660e\u306a\u70b9\u3082\u591a\u3044\u305f\u3081\u6cbb\u7642\u306b\u96e3\u6e0b\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u81ea\u5df1\u6297\u4f53\u306e\u9055\u3044\u306b\u3088\u308b\u81e8\u5e8a\u50cf\u3001\u753b\u50cf\u691c\u67fb\u30fb\u75c5\u7406\u5b66\u7684\u6240\u898b\u306e\u7279\u5fb4\u3084\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u89e3\u6790\u3057\u3066\u304a\u308a\u30012024\u5e74\u306b\u306f\u540c\u3058\u81ea\u5df1\u514d\u75ab\u6027\u708e\u75c7\u6027\u7b4b\u75be\u60a3\u306b\u304a\u3044\u3066\u3082ARS\u6297\u4f53\u3068SRP\u6297\u4f53\u3067\u306f\u5927\u817f\u90e8MRI\u306e\u7b4b\u708e\u6240\u898b\u304c\u7570\u306a\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

3\uff1a\u81a0\u539f\u75c5\u95a2\u9023\u9593\u8cea\u6027\u80ba\u75be\u60a3\u306b\u304a\u3051\u308b\u4e88\u5f8c\u4e88\u6e2c\u56e0\u5b50\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u63a2\u7d22<\/h4>\n\n\n\n

\u81a0\u539f\u75c5\u95a2\u9023\u9593\u8cea\u6027\u80ba\u75be\u60a3\u306f\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3084\u5168\u8eab\u6027\u5f37\u76ae\u75c7\u3001\u591a\u767a\u6027\u7b4b\u708e\/\u76ae\u819a\u7b4b\u708e\u306a\u3069\u306e\u5404\u81a0\u539f\u75c5\u306b\u304a\u3044\u3066\u983b\u5ea6\u306e\u9ad8\u3044\u81d3\u5668\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001\u81f4\u6b7b\u7684\u3067\u91cd\u8981\u306a\u5408\u4f75\u75c7\u3067\u3059\u3002\u4e00\u65b9\u3067\u3001\u8fd1\u5e74\u3067\u306f\u5f37\u76ae\u75c7\u95a2\u9023\u9593\u8cea\u6027\u80ba\u708e\u3084\u9032\u884c\u6027\u7dda\u7dad\u5316\u3092\u4f34\u3046\u9593\u8cea\u6027\u80ba\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6297\u7dda\u7dad\u5316\u85ac\u306e\u6cbb\u7642\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u81a0\u539f\u75c5\u95a2\u9023\u9593\u8cea\u6027\u80ba\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u9078\u629e\u80a2\u306f\u5897\u3048\u3064\u3064\u3042\u308a\u307e\u3059\u304c\u3001\u5b9f\u81e8\u5e8a\u306b\u304a\u3044\u3066\u6cbb\u7642\u5bfe\u8c61\u306e\u75c7\u4f8b\u306e\u9078\u629e\u304c\u96e3\u3057\u3044\u3053\u3068\u3082\u591a\u304f\u7d4c\u9a13\u3057\u307e\u3059\u3002\u3053\u3046\u3044\u3063\u305f\u80cc\u666f\u304b\u3089\u3001\u81a0\u539f\u75c5\u95a2\u9023\u9593\u8cea\u6027\u80ba\u75be\u60a3\u306e\u75c7\u4f8b\u306e\u60c5\u5831\u3092\u96c6\u7a4d\u3057\u3001\u8840\u6db2\u691c\u4f53\u3092\u7528\u3044\u3066\u6cbb\u7642\u52b9\u679c\u3084\u4e88\u5f8c\u3092\u4e88\u6e2c\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u63a2\u7d22\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u611f\u67d3\u75c7\u5185\u79d1<\/h3>\n\n\n\n

\uff11\uff1aSFTS\u306e\u75c5\u614b\u89e3\u660e\u3001\u691c\u67fb\u6cd5\u306e\u958b\u767a<\/strong><\/p>\n\n\n\n

SFTS\uff08\u91cd\u75c7\u71b1\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u5019\u7fa4\uff09\u306f\u3001\u30de\u30c0\u30cb\u306b\u3088\u3063\u3066SFTS\u30a6\u30a4\u30eb\u30b9\u304c\u5a92\u4ecb\u3055\u308c\u308b\u3053\u3068\u3067\u767a\u75c7\u3057\u3001\u56fd\u5185\u3067\u306e\u60a3\u8005\u5831\u544a\u6570\u306f\u5bae\u5d0e\u770c\u304c\u6700\u591a\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002SFTS\u306f\u91cd\u75c7\u5316\u306e\u6a5f\u5e8f\u3082\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3001\u81f4\u6b7b\u7387\u306f20-30%\u3068\u975e\u5e38\u306b\u9ad8\u3044\u305f\u3081\u3001\u75c5\u614b\u3092\u89e3\u660e\u3057\u9069\u5207\u304b\u3064\u8fc5\u901f\u306a\u8a3a\u65ad\u3092\u884c\u3046\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u7c21\u6613\u8fc5\u901f\u8a3a\u65ad\u691c\u67fb\u6cd5\u306e\u958b\u767a\u3092\u9032\u3081\u3001\u7279\u8a31\u7533\u8acb\u3092\u7d42\u3048\u307e\u3057\u305f\u3002\u81e8\u5e8a\u7814\u7a76\u306b\u3082\u529b\u3092\u5165\u308c\u3066\u304a\u308a\u3001\u540c\u3058\u304f\u30de\u30c0\u30cb\u5a92\u4ecb\u611f\u67d3\u75c7\u3067\u3042\u308b\u65e5\u672c\u7d05\u6591\u71b1\u3068\u306e\u6bd4\u8f03\u3084\u6b7b\u4ea1\u4e88\u6e2c\u56e0\u5b50\u306e\u691c\u8a0e\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u6295\u4e0e\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u30012023\u5e74\u304b\u3089\u306f\u5168\u56fd\u898f\u6a21\u306e\u591a\u65bd\u8a2d\u5171\u540c\u30ec\u30b8\u30b9\u30c8\u30ea\u3092\u7acb\u3061\u4e0a\u3052\u3066\u304a\u308a\u3001\u30c0\u30cb\u5a92\u4ecb\u611f\u67d3\u75c7\u306e\u8a3a\u65ad\u53ca\u3073\u6cbb\u7642\u306e\u6a19\u6e96\u5316\u3084\u3001\u4e88\u5f8c\u306e\u6539\u5584\u306b\u5411\u3051\u305f\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u8133\u795e\u7d4c\u5185\u79d1<\/h3>\n\n\n\n

\u7814\u7a76\u3068\u306f\u81ea\u5206\u304c\u8208\u5473\u3092\u6301\u3064\u3053\u3068\u3092\u81ea\u7531\u306b\u7a81\u304d\u8a70\u3081\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u898f\u6a21\u306e\u5c0f\u3055\u3044\u5730\u65b9\u5927\u5b66\u3067\u306f\u5358\u72ec\u306e\u8a3a\u7642\u79d1\u3084\u8b1b\u5ea7\u3067\u81ea\u5206\u304c\u3084\u308a\u305f\u3044\u30c6\u30fc\u30de\u3092\u6df1\u304f\u8ffd\u6c42\u3059\u308b\u3053\u3068\u306f\u73fe\u5b9f\u7684\u306b\u56f0\u96e3\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u81ea\u5206\u305f\u3061\u306e\u6bbb\u306b\u9589\u3058\u3053\u3082\u3089\u305a\u3001\u57fa\u790e\u533b\u5b66\u306e\u7814\u7a76\u5ba4\u3084\u4ed6\u5b66\u90e8\u3068\u3082\u7a4d\u6975\u7684\u306b\u4ea4\u6d41\u3057\u3066\u5171\u540c\u7814\u7a76\u306e\u8f2a\u3092\u5e83\u3052\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u300c\u81ea\u7531\u306b\u3001\u81ea\u5206\u306e\u3084\u308a\u305f\u3044\u3053\u3068\u3092\u3001\u6df1\u304f\u8ffd\u6c42\u3059\u308b\u300d\u3068\u3044\u3046\u7814\u7a76\u3092\u884c\u3046\u4e0a\u3067\u57fa\u672c\u7684\u306a\u59ff\u52e2\u3092\u5927\u5207\u306b\u3057\u3066\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1\uff1a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n

\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306f\u672a\u3060\u306b\u5341\u5206\u306b\u75c5\u614b\u304c\u89e3\u660e\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u3082\u306e\u3070\u304b\u308a\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8\u6a5f\u80fd\u751f\u5316\u5b66\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u5c0f\u80de\u4f53\u95a2\u9023\u5206\u89e3\u306b\u95a2\u308f\u308bDerlin\u30d5\u30a1\u30df\u30ea\u30fc\u304c\u6b20\u640d\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u7d30\u80de\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u304c\u4f4e\u4e0b\u3057\u3066\u5c0f\u8133\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u8133\u840e\u7e2e\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3001\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b4\u30d5\u30a7\u30cb\u30eb\u916a\u9178\u304c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u4f4e\u4e0b\u3068\u8133\u840e\u7e2e\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306fALS\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u53c8\u3001\u5927\u5b66\u9662\u751f\u304c\u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8\u5fae\u751f\u7269\u5b66\u306b\u6240\u5c5e\u3057\u3066\u30d7\u30ea\u30aa\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u57fa\u790e\u7814\u7a76\u3082\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n\n\n\n

1. Sugiyama T and Nishitoh, J Biochem. 2024<\/p>\n\n\n\n

2. Sugiyama T et al., Sci Rep. 2022<\/p>\n\n\n\n

3. Sugiyama T et al., iScience. 2021<\/p>\n\n\n\n

4. Nakazato Y et al., J Neurol Sci. 2015<\/p>\n\n\n\n

2\uff1a\u795e\u7d4c\u514d\u75ab\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n

\u8fd1\u5e74\u306e\u795e\u7d4c\u514d\u75ab\u5206\u91ce\u306b\u304a\u3051\u308b\u6cbb\u7642\u306e\u767a\u5c55\u306f\u51c4\u307e\u3058\u304f\u3001\u69d8\u3005\u306a\u5206\u5b50\u6a19\u7684\u85ac\u3092\u4f7f\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u300110\u5e74\u524d\u3067\u306f\u8003\u3048\u3089\u308c\u306a\u3044\u307b\u3069\u75be\u60a3\u306e\u6d3b\u52d5\u6027\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u307e\u3060\u591a\u767a\u6027\u786c\u5316\u75c7\u306a\u3069\u306e\u75c5\u614b\u89e3\u660e\u306f\u5341\u5206\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u6211\u3005\u306e\u4e2d\u304b\u3089\u3001\u56fd\u5185\u306b\u304a\u3051\u308b\u795e\u7d4c\u514d\u75ab\u5b66\u7684\u7814\u7a76\u306e\u5148\u7aef\u3092\u8d70\u3063\u3066\u3044\u308b\u5927\u962a\u5927\u5b66\u5206\u5b50\u795e\u7d4c\u79d1\u5b66\u306b\u56fd\u5185\u7559\u5b66\u3057\u3001\u5b9f\u9a13\u7684\u306b\u4e2d\u67a2\u795e\u7d4c\u306b\u708e\u75c7\u3092\u8a98\u5c0e\u3059\u308bEAE\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3092\u5b66\u3073\u306b\u884c\u304d\u307e\u3057\u305f\u3002\u795e\u7d4c\u304b\u3089\u5206\u6ccc\u3055\u308c\u308bCCL2\u3068\u3044\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u30ea\u30f3\u30d1\u7403\u306e\u8a98\u5c0e\u306b\u95a2\u308f\u308b\u3068\u3044\u3046\u65b0\u3057\u3044\u77e5\u898b\u3092\u5831\u544a\u3057\u3001\u73fe\u5728\u306fEAE\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u63a2\u7d22\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002
\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e
1. Nakazato et al., Sci Rep. 2020<\/p>\n\n\n\n

3\uff1a\u81e8\u5e8a\u795e\u7d4c\u751f\u7406\u304a\u3088\u3073\u795e\u7d4c\u75c7\u5019\u306e\u5b9a\u91cf\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n

\u4ee5\u524d\u304b\u3089\u5bae\u5d0e\u3067\u306f\u8133\u6ce2\u3084\u7b4b\u96fb\u56f3\u3068\u3044\u3063\u305f\u81e8\u5e8a\u795e\u7d4c\u751f\u7406\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3057\u305f\u304c\u3001\u77ac\u76ee\u53cd\u5c04\u3092\u5fdc\u7528\u3057\u3066\u5074\u5c48\u3092\u4f34\u3063\u305f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u75c7\u4f8b\u3067\u306f\u8133\u5e79\u6a5f\u80fd\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306f\u3001\u5bae\u5d0e\u5927\u5b66\u5de5\u5b66\u90e8\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u5f93\u6765\u306f\u5b9a\u6027\u7684\u3082\u3057\u304f\u306f\u534a\u5b9a\u91cf\u7684\u3067\u3057\u304b\u8a55\u4fa1\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u795e\u7d4c\u75c7\u5019\u3092\u5b9a\u91cf\u5316\u3067\u304d\u308b\u3088\u3046\u306a\u88c5\u7f6e\u3084\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n\n\n\n

1. Ishii N et al., J Neurol Sci. 2020<\/p>\n\n\n\n

2. Sugiyama T et al., J Clin Neurophysiol. 2018<\/p>\n\n\n\n

3. Sakai K et al., Epileptic Disord. 2018<\/p>\n\n\n\n

4. Hayashida T, Sugiyama T, Sakai K et al, Electronics. 2023<\/p>\n\n\n\n

4\uff1a\u795e\u7d4c\u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n

\u7d30\u83cc\u6027\u9ac4\u819c\u708e\u3092\u7b46\u982d\u3068\u3057\u305f\u795e\u7d4c\u611f\u67d3\u75c7\u306f\u9069\u5207\u306a\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u826f\u597d\u306a\u4e88\u5f8c\u304c\u671f\u5f85\u3067\u304d\u308b\u3082\u306e\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u4e00\u65b9\u3067\u6cbb\u7642\u306b\u305f\u3069\u308a\u7740\u304b\u305a\u3001\u81f4\u547d\u7684\u306b\u306a\u3063\u305f\u308a\u6df1\u523b\u306a\u6a5f\u80fd\u969c\u5bb3\u3092\u6b8b\u3057\u3066\u3057\u307e\u3063\u305f\u308a\u3059\u308b\u3082\u306e\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u6211\u3005\u306f\u3001\u7d30\u83cc\u6027\u9ac4\u819c\u708e\u75c7\u4f8b\u306e\u8133\u810a\u9ac4\u6db2\u4e2d\u3067LEAP2\u3068\u3044\u3046\u751f\u7406\u6d3b\u6027\u30da\u30d7\u30c1\u30c9\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u7d30\u83cc\u6027\u9ac4\u819c\u708e\u306e\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u306a\u308a\u3046\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u306f\u795e\u7d4c\u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u30ec\u30b8\u30b9\u30c8\u30ea\u7814\u7a76\u3092\u7acb\u3061\u4e0a\u3052\u3066\u4e88\u5f8c\u306b\u95a2\u308f\u308b\u56e0\u5b50\u306e\u89e3\u6790\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n\n\n\n

1. Sakai K, et al., Brain Behav. 2021<\/p>\n\n\n\n

2. Sakai K, Nakazato Y, et al., Endocr J. 2025<\/p>\n\n\n\n

<\/p>\n\n\n\n

5\uff1a\u81e8\u5e8a\u75ab\u5b66\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h4>\n\n\n\n

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\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n\n\n\n

1. Sugiyama T et al., Int J Environ Res Public Health. 2021<\/p>\n\n\n\n

2. Ishii N et al., J Neurol Sci. 2019<\/p>\n\n\n\n

3. Mochizuki H., Int. J. Mol. Sci. 2019<\/p>\n\n\n\n

4. Ishii N et al., Arch Environ Contam Toxicol. 2018<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"\u7814\u7a76\u5185\u5bb9\u306e\u7d39\u4ecb \u5352\u696d\u6570\u5e74\u76ee\u307e\u3067\u306e\u82e5\u624b\u306e\u5148\u751f\u65b9\u306b\u304a\u304b\u308c\u307e\u3057\u3066\u306f\u3001\u65e5\u3005\u306e\u81e8\u5e8a\u7814\u4fee\u306b\u71b1\u5fc3\u306b\u53d6\u308a\u7d44\u307e\u308c\u3001\u5145\u5b9f\u3057\u305f\u65e5\u3005\u3092\u9001\u3063\u3066\u3044\u3089\u3063\u3057\u3083\u308b\u3053\u3068\u3068\u601d\u3044\u307e\u3059\u3002\u3042\u308b\u7a0b\u5ea6\u81e8\u5e8a\u3092\u5b9f\u8df5\u3059\u308b\u3068\u3001\u3053\u306e\u75c5\u6c17\u306e\u6b63\u78ba\u306a\u8a3a\u65ad\u65b9\u6cd5\u306f\u306a\u306b\u304b\u3001\u672c\u5f53\u306e\u75c5\u614b\u306f\u306a\u306b","protected":false},"author":1,"featured_media":0,"parent":27,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false},"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/pages\/42"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/comments?post=42"}],"version-history":[{"count":35,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/pages\/42\/revisions"}],"predecessor-version":[{"id":1970,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/pages\/42\/revisions\/1970"}],"up":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/pages\/27"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/resprheuminfecneur9640\/wp-json\/wp\/v2\/media?parent=42"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}