{"id":21,"date":"2014-08-18T15:43:28","date_gmt":"2014-08-18T06:43:28","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/?page_id=21"},"modified":"2026-01-28T13:32:50","modified_gmt":"2026-01-28T04:32:50","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"

2026\u5e74<\/h4>\n

Syaban MFR<\/span>, Shalihah SM<\/span>, Kage Y<\/span>, Sulistomo HW, Takeya R<\/span>. Structural basis underlying the autoinhibition of the formin FHOD1 and its phosphorylation-dependent activation. J. Biol. Chem.<\/em><\/strong> 2026; 302: 111109. doi: 10.1016\/j.jbc.2025.111109.<\/a><\/p>\n

Shii H, Minami K, Takeya R<\/span>, Ikeda R. BHLHE41 Enhances Gemcitabine Sensitivity of Pancreatic Cancer Cells Through IGFBP4 Suppression. Anticancer Res.<\/em><\/strong> 2026 Jan;46:213-226. doi: 10.21873\/anticanres.17936.<\/a><\/p>\n

2025\u5e74<\/h4>\n

Kouroki S, Maruta T, Hidaka K, Koshida T, Kurogi M, Kage Y<\/span>, Miura A<\/span>, Nakagawa H<\/span>, Yanagita T, Takeya R<\/span>, Tsuneyoshi I.Reversible neuropathic pain model created by long-term optogenetic nociceptor stimulation using light-responsive pain mice. PLoS One.<\/strong><\/em> 2025;20:e0323628. doi: 10.1371\/journal.pone.0323628.<\/a><\/p>\n

Zhang W, Nakazato Y, Minamino N, Okumura N, Miura A<\/span>, Tarusawa T, Mizukami H, Sakoda H, Nakazato M. NERP-4-Deleted VGF Impairs \u03b2-Cell Granulogenesis and Insulin Secretion. FASEB J<\/em><\/strong>. 2025 Dec 31;39(24):e71365. doi: 10.1096\/fj.202502474R.<\/a><\/p>\n

2024\u5e74<\/h4>\n

Boussaty EC, Ninoyu Y, Andrade L, Li Q, Takeya R<\/u>, Sumimoto H, Ohyama T, Wahlin KJ, Manor U, Friedman RA. Altered Fhod3 Expression Involved in Progressive High-Frequency Hearing Loss via Dysregulation of Actin Polymerization Stoichiometry in The Cuticular Plate. PLoS Genet<\/em><\/strong>. 2024; 20: e1011211. doi: 10.1371\/journal.pgen.1011211. <\/a><\/p>\n

Yamamoto E, Kanaoka M, Nemoto T<\/u>, Kinoshita Y, Takeya R<\/u>, Yanagita T. Effectiveness of Interprofessional Education Based on the Case-and Communication-Based Approach. IAFOR Journal of Psychology & the Behavioral Sciences,<\/em> <\/strong>9<\/em>(2). https:\/\/doi.org\/10.22492\/ijpbs.9.2.03<\/a><\/p>\n

Maruta T, Kouroki S, Kurogi M, Hidaka K, Koshida T, Miura A<\/span>, Nakagawa H<\/span>, Yanagita T, Takeya R<\/span>, and Tsuneyoshi I. Comparison of nocifensive behavior in NaV<\/sub>7-, NaV<\/sub>1.8-, and NaV<\/sub>1.9-Channelrhodopsin-2 mice by selective optogenetic activation of targeted sodium channel subtype-expressing afferents. J. Neurosci. Res.,<\/em><\/strong> 2024; 102 :e25386. doi: 10.1002\/jnr.25386.<\/p>\n

Nakagawa H<\/span>, Kage Y<\/span>, Miura A<\/span>, Sulistomo HW<\/span>, Matsuyama S<\/span>, Yamashita Y, and Takeya R<\/span>. The expression of the formin Fhod3 in mouse tongue striated muscle. Cell Struct. Funct.,<\/em><\/strong> 2024. doi: 10.1247\/csf.24044.<\/a><\/p>\n

2023\u5e74<\/h4>\n

Zhang W*, Miura A* (*contributed equally)<\/u>, Abu Saleh MM, Shimizu K, Mita Y, Tanida R, Hirako S, Shioda S, Gmyr V, Kerr-Conte J, Pattou F, Jin C, Kanai Y, Sasaki K, Minamino N, Sakoda H, and Nakazato M. The NERP-4\u2013SNAT2 axis regulates pancreatic \u03b2-cell maintenance and function. Nat Commun<\/em><\/strong> 2023; 14: 8158. doi: 10.1038\/s41467-023-43976-8<\/a><\/p>\n

Koshida T, Maruta T, Tanaka N, Hidaka K, Kurogi M, Nemoto T, Yanagita T, Takeya R<\/u>, Tsuneyoshi I. \u00a0Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve. Acta Medica Okayama<\/em><\/strong>. 2023; 17: e0275751. doi: 18926\/AMO\/65741<\/a>.<\/p>\n

2022\u5e74<\/h4>\n

Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y<\/span>, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R<\/span>, Tsuneyoshi I.Selective optogenetic activation of NaV<\/sub>1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.PLoS One.<\/strong><\/em> 2022 ;17:e0275751. doi: 10.1371\/journal.pone.0275751.<\/a><\/p>\n

Hidaka K, Maruta T, Koshida T, Kurogi M, Kage Y<\/span>, Kouroki S, Shirasaka T, Takeya R<\/span>, Tsuneyoshi I. Extracellular signal-regulated kinase phosphorylation enhancement and NaV<\/sub>1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic pain: The efficacy and mechanism of pulsed radiofrequency therapy. Molecular Pain<\/i><\/strong>. 2022\u00a0;18:1-12. doi:10.1177\/17448069221089784<\/a><\/p>\n

2021\u5e74<\/h4>\n

Sakata K<\/span>, Matsuyama S<\/span>, Kurebayashi N, Hayamizu K, Murayama T, Nakamura K, Kitamura K, Morimoto S, Takeya R<\/span>. \u00a0Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+<\/sup> handling in frog and mouse cardiomyocytes.\u00a0Genes Cells.<\/strong><\/em> 2021 Jun 1. doi: 10.1111\/gtc.12873.<\/a><\/p>\n

Sulistomo HW<\/span>, Nemoto T<\/span>, Kage Y<\/span>, Fujii H, Uchida T, Takamiya K, Sumimoto H, Kataoka H, Bito H, and\u00a0Takeya R<\/span>. Fhod3 controls the dendritic spine morphology of specific subpopulations of pyramidal neurons in the mouse cerebral cortex.\u00a0Cerebral Cortex<\/em><\/strong>\u00a02021;31:2205\u20132219.\u00a0doi<\/span>: 10.1093\/cercor\/bhaa355. \u00a0Free-access article link<\/a><\/p>\n

2019\u5e74<\/h4>\n

Maruta T, Nemoto T<\/span>, Hidaka K, Koshida T, Shirasaka T, Yanagita T, Takeya R<\/span>, Tsuneyoshi I.\u00a0Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain. PLoS ONE<\/strong><\/em>\u00a02019;14:e0225586.<\/p>\n

Sanematsu F<\/span>, Kanai A<\/span>, Ushijima T<\/span>, Shiraishi A, Abe T, Kage Y<\/span>, Sumimoto H, Takeya R<\/span>.\u00a0Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice. Cytoskeleton (Hoboken).\u00a0<\/strong><\/em>2019 Feb;76(2):219-229. doi: 10.1002\/cm.21523.<\/a><\/p>\n

2018\u5e74<\/h4>\n

Matsuyama S<\/span>, Kage Y,<\/span> Fujimoto N<\/span>, Ushijima<\/span> T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R<\/span>. Interaction between cardiac myosin-binding protein C and formin Fhod3. Proc Natl Acad Sci U S A.<\/strong><\/em> 2018 ; 115: E4386-95. doi: 10.1073\/pnas.1716498115.<\/a><\/p>\n

Sulistomo HW<\/span>, Nemoto T<\/span>, Yanagita T, Takeya R<\/span>. Formin homology 2 domain-containing 3 controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction. J Biol Chem.<\/strong><\/em> 2018 Dec 20. pii: jbc.RA118.005471. doi: 10.1074\/jbc.RA118.005471.<\/p>\n

2017\u5e74<\/h4>\n

Ushijima T<\/span>, Fujimoto N<\/span>, Matsuyama S<\/span>, Kan-o M<\/span>, Kiyonari H, Shioi G, Kage Y<\/span>, Yamasaki S, Takeya R<\/span>, Sumimoto H. The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice. J Biol Chem.<\/strong><\/em> 2018 Jan 5;293(1):148-162.<\/p>\n

2016\u5e74<\/h4>\n

Fujimoto N<\/span>, Kan-o M<\/span>, Ushijima T<\/span>, Kage Y<\/span>, Tominaga R, Sumimoto H, Takeya R<\/span>. Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis. PLoS One<\/strong><\/em>. 2016;11:e0148472.<\/p>\n

2015\u5e74<\/h4>\n

Yanagihara T, Sanematsu F<\/span>, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Fukui Y. Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nat Commun<\/strong><\/em>. 2015;6:8820.<\/p>\n

Yanagita T, Nemoto T<\/span>, Takeya R<\/span>. [Role-play for pharmacology education: active learning through the Case & Communication based approach]. Nihon Yakurigaku Zasshi<\/strong><\/em>. 2015;146:115-8.<\/span><\/p>\n

2014\u5e74<\/span><\/h4>\n

Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F<\/span>, Nishikimi A, C\u00f4t\u00e9 JF, Sumimoto H, Fukui Y. DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. J Immunol.<\/strong><\/em> 2014;193:5660-7.<\/span><\/p>\n

Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F<\/span>, Yamamura K, Terasawa M, Nishikimi A, C\u00f4t\u00e9 JF, Fukui Y. DOCK5 functions as a key signaling adaptor that links Fc\u03b5RI signals to microtubule dynamics during mast cell degranulation. J Exp Med.<\/strong><\/em> 2014 ;211:1407-19.<\/span><\/p>\n

Nakamura K, Shimizu T, Yanagita T, Nemoto T<\/span>, Taniuchi K, Shimizu S, Dimitriadis F, Yawata T, Higashi Y, Ueba T, Saito M. Angiotensin II acting on brain AT1 receptors induces adrenaline secretion and pressor responses in the rat. Sci Rep.<\/em><\/strong> 2014; 4: 7248.<\/span><\/p>\n

Tamura R, Nemoto T<\/span>, Maruta T, Onizuka S, Yanagita T, Wada A, Murakami M, Tsuneyoshi I. Up-regulation of Na(V)1.7 sodium channels expression by tumor necrosis factor-\u03b1 in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons. Anesth Analg.<\/em><\/strong> 2014; 118: 318-324 \u3000<\/span><\/p>\n

Nemoto T<\/span>, Toyoshima-Aoyama F, Yanagita T, Murata T, Fujita H, Koshida T, Yonaha T, Wada A, Sawaguchi A, Murakami M. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: Amyloid-\u03b21-42-induced reduction of proinsulin level via glycogen synthase kinase-3\u03b2. Cellular Signal. <\/em><\/strong>2014; 26: 253-259.<\/span><\/p>\n

Tanaka K, Shimizu T, Yanagita T, Nemoto T<\/span>, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M. Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat. Br J Pharmacol.<\/em><\/strong> 2014; 171: 202-213.<\/span><\/p>\n

2013\u5e74\u4ee5\u524d<\/span><\/h4>\n

\u6b66\u8c37\u3000\u7acb<\/p>\n

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2026\u5e74 Syaban MFR, Shalihah SM, Kage Y, Sulistomo HW, Takeya R. Structural basis underlying the autoinhibition … <\/p>\n

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