{"id":15,"date":"2014-08-18T15:09:01","date_gmt":"2014-08-18T06:09:01","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/?page_id=15"},"modified":"2024-03-23T11:25:46","modified_gmt":"2024-03-23T02:25:46","slug":"%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9","status":"publish","type":"page","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<h5><span style=\"color: #333333;font-size: 13px;font-weight: bold;line-height: normal\">\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76<\/span><\/h5>\n<div id=\"attachment_139\" style=\"width: 160px\" class=\"wp-caption alignright\"><a href=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/files\/2014\/08\/37e3808047553cedb34daa9b1d7ab2a3.jpg\"><img aria-describedby=\"caption-attachment-139\" loading=\"lazy\" class=\"size-thumbnail wp-image-139 \" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/files\/2014\/08\/37e3808047553cedb34daa9b1d7ab2a3-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" \/><\/a><p id=\"caption-attachment-139\" class=\"wp-caption-text\">\u5fc3\u7b4b\u306e\u53ce\u7e2e\u88c5\u7f6e\u30b5\u30eb\u30b3\u30e1\u30a2<\/p><\/div>\n<p>\u7d30\u80de\u9aa8\u683c\u306f\u3001\u305d\u306e\u69cb\u6210\u56e0\u5b50\u3067\u3042\u308b\u5358\u91cf\u4f53\u306e\u91cd\u5408\u30fb\u8131\u91cd\u5408\u306b\u3088\u308a\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u305d\u306e\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u3066\u3001\u7d30\u80de\u904b\u52d5\u3092\u3072\u304d\u304a\u3053\u3059\u3002\u4e2d\u3067\u3082\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306f\u3001\u91cd\u5408\u3057\u305f\u76f4\u7dda\u72b6\u306e\u30a2\u30af\u30c1\u30f3\u7dda\u7dad\u304c\u30df\u30aa\u30b7\u30f3\u7dda\u7dad\u3068\u300c\u53ce\u7e2e\u88c5\u7f6e\u300d\u3092\u5f62\u4f5c\u308b\u3053\u3068\u3067\u52b9\u7387\u7684\u306a\u529b\u306e\u767a\u751f\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u5f62\u614b\u5909\u5316\u306e\u307f\u306a\u3089\u305a\u500b\u4f53\u30ec\u30d9\u30eb\u3067\u306e\u904b\u52d5\u30fb\u59ff\u52e2\u5236\u5fa1\u304b\u3089\u547c\u5438\u30fb\u5faa\u74b0\u3068\u3044\u3063\u305f\u751f\u547d\u6a5f\u80fd\u306e\u672c\u8cea\u90e8\u5206\u3092\u62c5\u3063\u3066\u3044\u308b\u3002\u3053\u306e\u30a2\u30af\u30c1\u30f3\u53ce\u7e2e\u88c5\u7f6e\u306e\u53ce\u7e2e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306b\u3088\u308a\u57fa\u672c\u7684\u306b\u89e3\u660e\u3055\u308c\u3066\u304d\u305f\u304c\u3001\u53ce\u7e2e\u88c5\u7f6e\u306e\u5f62\u6210\u30fb\u7dad\u6301\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u77e5\u898b\u306f\u975e\u5e38\u306b\u4e4f\u3057\u3044\u3002\u53ce\u7e2e\u88c5\u7f6e\u3092\u69cb\u6210\u3059\u308b\u76f4\u7dda\u72b6\u306e\u30a2\u30af\u30c1\u30f3\u7dda\u7dad\u3082\u3001\u91cd\u5408\u306b\u3088\u308a\u5f62\u6210\u30fb\u7dad\u6301\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u30a2\u30af\u30c1\u30f3\u91cd\u5408\u306f\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u304c\u3001\u305d\u306e\u8a73\u7d30\u306f\u307b\u307c\u672a\u89e3\u6c7a\u3067\u3042\u308b\u3002\u3000\u79c1\u9054\u306f\u3001\u53ce\u7e2e\u88c5\u7f6e\u5f62\u6210\u306b\u304a\u3051\u308b\u30a2\u30af\u30c1\u30f3\u91cd\u5408\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u4e2d\u5fc3\u306b\u3001\u30a2\u30af\u30c1\u30f3\u53ce\u7e2e\u88c5\u7f6e\u306e\u5f62\u6210\u3068\u6052\u5e38\u6027\u7dad\u6301\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u306b\u6311\u3093\u3067\u3044\u308b\u3002<\/p>\n<p><span style=\"text-decoration: underline\">\u4ee3\u8868\u8ad6\u6587<\/span><\/p>\n<p>Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R. Interaction between cardiac myosin-binding protein C and formin Fhod3. <em><strong>Proc Natl Acad Sci U S A.<\/strong><\/em> 2018 ; 115: E4386-95. <a href=\"https:\/\/doi.org\/10.1073\/pnas.1716498115\">doi: 10.1073\/pnas.1716498115.<\/a><\/p>\n<p>Ushijima T, Fujimoto N, Matsuyama S, Kan-o M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H. The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice. <em><strong>J Biol Chem.<\/strong><\/em> 2018;293:148-162.<\/p>\n<p>Kan-O M, <span style=\"text-decoration: underline\">Takeya R<\/span>, Abe T, Kitajima N, Nishida M, Tominaga R, Kurose H, Sumimoto H. Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. <em><strong>Biol Open<\/strong><\/em>. 2012;1:889-96.<\/p>\n<p>Kan-o M, <span style=\"text-decoration: underline\">Takeya R<\/span>, Taniguchi K, Tanoue Y, Tominaga R, Sumimoto H. Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart. <em><strong>PLoS One.<\/strong><\/em> 2012;7(4):e34765.<\/p>\n<p>Taniguchi K, <span style=\"text-decoration: underline\">Takeya R<\/span>, Suetsugu S, Kan-O M, Narusawa M, Shiose A, Tominaga R, Sumimoto H. Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. <em><strong>J Biol Chem.<\/strong><\/em> 2009 ; 284:29873-81.<\/p>\n<h5><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306b\u95a2\u3059\u308b\u7814\u7a76<\/strong><\/h5>\n<div id=\"attachment_165\" style=\"width: 310px\" class=\"wp-caption alignright\"><a href=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/files\/2014\/08\/7dd4c3f74f006b34bb1d70d7adebd54e.jpg\"><img aria-describedby=\"caption-attachment-165\" loading=\"lazy\" class=\"size-medium wp-image-165\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/files\/2014\/08\/7dd4c3f74f006b34bb1d70d7adebd54e-300x111.jpg\" alt=\"\" width=\"300\" height=\"111\" srcset=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/files\/2014\/08\/7dd4c3f74f006b34bb1d70d7adebd54e-300x111.jpg 300w, http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/files\/2014\/08\/7dd4c3f74f006b34bb1d70d7adebd54e.jpg 623w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-165\" class=\"wp-caption-text\">\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u6d77\u99ac\u30cb\u30e5\u30fc\u30ed\u30f3<\/p><\/div>\n<p>\u8133\u5185\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u56de\u8def\u7db2\u306e\u5f62\u6210\u30fb\u7dad\u6301\u30fb\u4fee\u5fa9\u3092\u4fc3\u3057\u3001\u4ee3\u8b1d\u969c\u5bb3\u3084\u708e\u75c7\u53cd\u5fdc\u306b\u8d77\u56e0\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u795e\u7d4c\u3092\u4fdd\u8b77\u3057\u3066\u3044\u308b\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u767a\u75c7\u6642\u3001\u8a18\u61b6\u30fb\u5b66\u7fd2\u3092\u53f8\u308b\u6d77\u99ac\u9818\u57df\u306b\u304a\u3044\u3066\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u306e\u6a5f\u80fd\u306f\u7834\u7dbb\u3057\u3066\u3044\u308b\u3002\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u51dd\u96c6\u306b\u3088\u308b\u8001\u4eba\u73ed\u3084\u30bf\u30a6\u904e\u5270\u30ea\u30f3\u9178\u5316\u306b\u4f34\u3046\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\u306a\u3069\u3092\u8d77\u56e0\u3068\u3059\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4e0d\u5168\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u69d8\u306e\u75c5\u614b\u751f\u7406\u5b66\u7684\u5909\u5316\u304c\u8133\u5185\u3067\u78ba\u8a8d\u3055\u308c\u305f\u3002\u305d\u308c\u3089\u306e\u75c5\u7406\u5b66\u7684\u5909\u5316\u3092\u8a8d\u3081\u305f\u8133\u306f\u3001\u4ee3\u8b1d\u969c\u5bb3\u3084\u708e\u75c7\u53cd\u5fdc\u306b\u8d77\u56e0\u3055\u308c\u308b\u3055\u307e\u3056\u307e\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u304d\u308f\u3081\u3066\u8106\u5f31\u3067\u3042\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u3092\u3055\u3089\u306b\u52a0\u901f\u3055\u305b\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002\u79c1\u305f\u3061\u306f\u672a\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u300c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u614b\u6642\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4e0d\u5168\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u6a5f\u80fd\u4e0d\u5168\u306e\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u300d\u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u304a\u3053\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n<p><span style=\"text-decoration: underline\">\u4ee3\u8868\u8ad6\u6587<\/span><\/p>\n<p><span style=\"text-decoration: underline\">Nemoto T<\/span>, Toyoshima-Aoyama F, Yanagita T, Murata T, Fujita H, Koshida T, Yonaha T, Wada A, Sawaguchi A, Murakami M. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: Amyloid-\u03b21-42-induced reduction of proinsulin level via glycogen synthase kinase-3\u03b2. <strong><em>Cellular Signal. <\/em><\/strong>2014; 26: 253-259.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76 \u7d30\u80de\u9aa8\u683c\u306f\u3001\u305d\u306e\u69cb\u6210\u56e0\u5b50\u3067\u3042\u308b\u5358\u91cf\u4f53\u306e\u91cd\u5408\u30fb\u8131\u91cd\u5408\u306b\u3088\u308a\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u305d\u306e\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u3066\u3001\u7d30\u80de\u904b\u52d5\u3092\u3072\u304d\u304a\u3053\u3059\u3002\u4e2d\u3067\u3082\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u306f\u3001\u91cd\u5408\u3057\u305f\u76f4\u7dda\u72b6\u306e\u30a2\u30af\u30c1\u30f3\u7dda\u7dad\u304c\u30df\u30aa\u30b7\u30f3\u7dda &hellip; <\/p>\n<p><a class=\"more-link block-button\" href=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9\/\">\u7d9a\u304d\u3092\u8aad\u3080 &raquo;<\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"open","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false},"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/pages\/15"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":51,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":634,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/pages\/15\/revisions\/634"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pharmacology\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}