{"id":1275,"date":"2025-04-07T10:35:20","date_gmt":"2025-04-07T01:35:20","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/?p=1275"},"modified":"2025-04-08T09:13:17","modified_gmt":"2025-04-08T00:13:17","slug":"%e8%a1%80%e6%a0%93%e3%83%bb%e6%ad%a2%e8%a1%80%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%80%81%e5%87%9d%e5%9b%baxi%e5%9b%a0%e5%ad%90%e3%81%ae%e5%b1%80%e5%9c%a8%e3%81%a8%e4%bd%9c%e7%94%a8%e3%81%ab%e9%96%a2","status":"publish","type":"post","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/2025\/04\/%e8%a1%80%e6%a0%93%e3%83%bb%e6%ad%a2%e8%a1%80%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%80%81%e5%87%9d%e5%9b%baxi%e5%9b%a0%e5%ad%90%e3%81%ae%e5%b1%80%e5%9c%a8%e3%81%a8%e4%bd%9c%e7%94%a8%e3%81%ab%e9%96%a2\/","title":{"rendered":"\u51dd\u56faXI\u56e0\u5b50\u306e\u5c40\u5728\u3068\u4f5c\u7528\u306b\u95a2\u3059\u308b\u539f\u8457\u8ad6\u6587\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"\n<div id=\"attachment_1277\" style=\"width: 1555px\" class=\"wp-caption alignnone\"><a href=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/files\/2025\/04\/1-s2.0-S2475037925000445-ga1_lrg.jpg\"><img aria-describedby=\"caption-attachment-1277\" loading=\"lazy\" class=\"size-full wp-image-1277\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/files\/2025\/04\/1-s2.0-S2475037925000445-ga1_lrg.jpg\" alt=\"\" width=\"1545\" height=\"886\" \/><\/a><p id=\"caption-attachment-1277\" class=\"wp-caption-text\"><a href=\"https:\/\/doi.org\/10.1016\/j.rpth.2025.102720\"><em><strong>Oguri N, et al. Res Pract Thromb Haemost. 2025;9:102720.<\/strong><\/em><\/a><\/p><\/div>\n<p>\u8840\u6db2\u51dd\u56fa\u56e0\u5b50XI\uff08FXI\uff09\u306f\u3001\u51dd\u56fa\u4f5c\u7528\u3092\u6709\u3057\u306a\u304c\u3089\u3082\u3001\u6b62\u8840\u306b\u306f\u5927\u304d\u304f\u95a2\u4e0e\u3057\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u3001\u6297\u51dd\u56fa\u85ac\u306f\u526f\u4f5c\u7528\u3068\u3057\u3066\u51fa\u8840\u30ea\u30b9\u30af\u304c\u554f\u984c\u3068\u306a\u308a\u307e\u3059\u304c\u3001FXI\u306f\u3001\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u65b0\u898f\u6297\u51dd\u56fa\u85ac\u306e\u6a19\u7684\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br 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vitro\uff08\u30d5\u30ed\u30fc\u30c1\u30e3\u30f3\u30d0\u30fc\uff09\u30b7\u30b9\u30c6\u30e0\u3067\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<br \/><br \/><strong>\u25cf\u30d2\u30c8DVT\u306b\u304a\u3051\u308bFXI\u306e\u5c40\u5728<\/strong><br \/>\u3000\u6df1\u90e8\u9759\u8108\u8840\u6813\u306f\u65b0\u9bae\u90e8\u3001\u7d30\u80de\u6eb6\u89e3\u90e8\u3001\u5668\u8cea\u5316\u90e8\u306e\u7570\u306a\u308b\u6642\u76f8\u306e\u8840\u6813\u6210\u5206\u304c\u7a2e\u3005\u306e\u5272\u5408\u3067\u6df7\u5728\u3057\u3066\u3044\u307e\u3057\u305f\u3002FXI\u306f\u3059\u3079\u3066\u306e\u8840\u6813\u306b\u5b58\u5728\u3057\u3066\u304a\u308a\u3001\u4e3b\u3068\u3057\u3066\u30d5\u30a3\u30d6\u30ea\u30f3\u306b\u4e00\u81f4\u3057\u3066\u5c40\u5728\u3057\u3001\u7279\u306b\u975e\u5668\u8cea\u5316\u9818\u57df\u306b\u591a\u304f\u5206\u5e03\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u96fb\u5b50\u9855\u5fae\u93e1\u89e3\u6790\u3067\u306f\u3001FXI\u304c\u30d5\u30a3\u30d6\u30ea\u30f3\u69d8\u30e1\u30c3\u30b7\u30e5\u69cb\u9020\u306b\u96c6\u7a4d\u3057\u3066\u3044\u308b\u69d8\u5b50\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<br \/><br \/><strong>\u25cf\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306eFXIa\u963b\u5bb3\u85ac\uff08ONO-1600586\uff09\u306e\u52b9\u679c\u304a\u3088\u3073FXa\u963b\u5bb3\u85ac\u3068\u306e\u6bd4\u8f03<\/strong><br \/>\u3000FXIa\u963b\u5bb3\u85ac\u306f\u3001\u5bb6\u514e\u306e\u9838\u90e8\u9759\u8108\u8840\u6813\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u8840\u6813\u5f62\u6210\u3092\u6291\u5236\u3055\u305b\u3001\u5927\u817f\u52d5\u8108\u51fa\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u51fa\u8840\u6642\u9593\u304a\u3088\u3073\u51fa\u8840\u91cf\u306b\u306f\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u3068\u3044\u3046\u7279\u7570\u306a\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u5f93\u6765\u306eFXa\u963b\u5bb3\u85ac\uff08\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3\uff09\u306f\u8840\u6813\u5f62\u6210\u3092\u6291\u5236\u3057\u3064\u3064\u3082\u3001\u51fa\u8840\u50be\u5411\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002<br \/><br \/><strong>\u25cf\u30d5\u30ed\u30fc\u30c1\u30e3\u30f3\u30d0\u30fc\u306b\u3088\u308b\u30d5\u30a3\u30d6\u30ea\u30f3\u5f62\u6210\u306e\u9055\u3044<\/strong><br \/>\u3000\u4f4e\u305a\u308a\u901f\u5ea6\u4e0b\u306b\u304a\u3051\u308b\u30d5\u30ed\u30fc\u30c1\u30e3\u30f3\u30d0\u30fc\u30b7\u30b9\u30c6\u30e0\u3067\u306f\u5bb6\u514e\u304a\u3088\u3073\u30d2\u30c8\u306e\u5168\u8840\u3067\u30d5\u30a3\u30d6\u30ea\u30f3\u5f62\u6210\u306e\u6e1b\u5c11\u3084\u9084\u6d41\u5f8c\u306e\u30d7\u30ed\u30c8\u30ed\u30f3\u30d3\u30f3\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8f1+2\u306e\u6e1b\u5c11\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u304c\u3001FXa\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u304c\u3088\u308a\u5f37\u304f\u3001\u4f4e\u305a\u308a\u901f\u5ea6\u4e0b\u306b\u304a\u3051\u308b\u30c8\u30ed\u30f3\u30d3\u30f3\u7523\u751f\u3084\u30d5\u30a3\u30d6\u30ea\u30f3\u5f62\u6210\u3078\u306e\u95a2\u4e0e\u306e\u9055\u3044\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br \/><br \/>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u30d2\u30c8DVT\u306b\u304a\u3051\u308bFXI\u306e\u5b58\u5728\u3068\u75c5\u614b\u751f\u7406\u5b66\u7684\u610f\u7fa9\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001FXIa\u963b\u5bb3\u85ac\u306f\u8840\u6813\u5f62\u6210\u6291\u5236\u3068\u51fa\u8840\u30ea\u30b9\u30af\u4f4e\u6e1b\u3092\u4e21\u7acb\u3057\u5f97\u308b\u65b0\u898f\u6297\u51dd\u56fa\u7642\u6cd5\u3068\u3057\u3066\u3001\u81e8\u5e8a\u5fdc\u7528\u3078\u306e\u5927\u304d\u306a\u53ef\u80fd\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<br \/><br \/>\u63b2\u8f09\u8ad6\u6587\u30fb\u30ea\u30f3\u30af\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002(Open access\u3067\u3042\u308a\u3001\u3069\u306a\u305f\u3067\u3082\u95b2\u89a7\u30fb\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3067\u304d\u307e\u3059)<br \/><br \/>Oguri N, Gi T, Nakamura E, Maekawa K, Furukoji E, Okawa H, Kouyama S, Horiuchi S, Sawaguchi A, Sakae T, Azuma M, Asada Y, Yamashita A. Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis. <em data-start=\"333\" data-end=\"360\"><strong>Res Pract Thromb Haemost<\/strong>.<\/em> 2025;9:102720. <a href=\"https:\/\/doi.org\/10.1016\/j.rpth.2025.102720\">https:\/\/doi.org\/10.1016\/j.rpth.2025.102720<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8840\u6db2\u51dd\u56fa\u56e0\u5b50XI\uff08FXI\uff09\u306f\u3001\u51dd\u56fa\u4f5c\u7528\u3092\u6709\u3057\u306a\u304c\u3089\u3082\u3001\u6b62\u8840\u306b\u306f\u5927\u304d\u304f\u95a2\u4e0e\u3057\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u3001\u6297\u51dd\u56fa\u85ac\u306f\u526f\u4f5c\u7528\u3068\u3057\u3066\u51fa\u8840\u30ea\u30b9\u30af\u304c\u554f\u984c\u3068\u306a\u308a\u307e\u3059\u304c\u3001FXI\u306f\u3001\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u65b0\u898f\u6297\u51dd\u56fa\u85ac\u306e\u6a19\u7684\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059 &hellip; <a href=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/2025\/04\/%e8%a1%80%e6%a0%93%e3%83%bb%e6%ad%a2%e8%a1%80%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%80%81%e5%87%9d%e5%9b%baxi%e5%9b%a0%e5%ad%90%e3%81%ae%e5%b1%80%e5%9c%a8%e3%81%a8%e4%bd%9c%e7%94%a8%e3%81%ab%e9%96%a2\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":96,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false},"categories":[9],"tags":[],"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/posts\/1275"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/users\/96"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/comments?post=1275"}],"version-history":[{"count":5,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/posts\/1275\/revisions"}],"predecessor-version":[{"id":1282,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/posts\/1275\/revisions\/1282"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/media?parent=1275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/categories?post=1275"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/wp-json\/wp\/v2\/tags?post=1275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}