{"id":1381,"date":"2025-12-09T09:03:14","date_gmt":"2025-12-09T00:03:14","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/?page_id=1381"},"modified":"2026-02-05T11:37:22","modified_gmt":"2026-02-05T02:37:22","slug":"2025-2","status":"publish","type":"page","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/pathophysiology\/2025-2\/","title":{"rendered":"2025"},"content":{"rendered":"\n

\uff08\u539f\u8457\u8ad6\u6587\uff09<\/strong><\/p>\n

    \n
  1. Maekawa K, Nakamura E, Saito Y, Matsuura Y, Gi T, Nishihira K, Oguri N, Moriguchi-Goto S, Sato Y, Hatakeyama K, Shibata Y, Komohara Y, Kaikita K, Asada Y, Yamashita A. Inflammatory stimuli and hypoxia on atherosclerotic plaque thrombogenicity: Linking macrophage tissue factor and glycolysis. PLoS One. 2025;20:e0316474. doi: 10.1371\/journal.pone.0316474<\/a><\/li>\n
  2. Oguri N, Gi T, Nakamura E, Maekawa K, Furukoji E, Okawa H, Kouyama S, Horiuchi S, Sawaguchi A, Sakae T, Azuma M, Asada Y, Yamashita A. Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis. Res Pract Thromb Haemost. 2025;9:102720. doi: 10.1016\/j.rpth.2025.102720<\/a><\/li>\n
  3. Wang S, Saneyoshi H, Xu P, Oguri N, Yamashita A, Xu Y. Manipulating DNA and RNA structures via click-to-release caged nucleic acids for biological and biomedical applications. Nucleic Acids Res. 2025;53:gkaf571.<\/li>\n
  4. Yamaguchi F, Akieda-Asai S, Nakamura E, Uchida H, Yamashita A, Date Y. Continuous exposure of nonobese adult male rats to a soft-textured, readily absorbable diet induces insulin resistance and derangements in hepatic glucose and lipid metabolism. J Nutr. 2025;155:1387-1397.<\/li>\n
  5. Joho T, Zhao S, Nishijima KI, Ukon N, Shimoyama S, Yamashita A, Washino K, Higashi T, Kobayakawa M, Shiga T, Takahashi K, Ito H. Extended single-dose toxicity study of [211At]meta-astatobenzylguanidine in normal mice in preparation for the first-in-human clinical trial of targeted alpha therapy for pheochromocytoma and paraganglioma. Ann Nucl Med. 2025;39:994-1013.<\/li>\n
  6. Japan Maternal Death Exploratory Committee (Collaborators: Aman M). Proposals for improving maternal safety (2023 edition): Insights from the analysis of maternal deaths in Japan. J Obstet Gynaecol Res. 2025;51:e16244. doi: 10.1111\/jog.16244.<\/a><\/li>\n<\/ol>\n

    \uff08\u75c7\u4f8b\u5831\u544a\uff09<\/strong><\/p>\n

      \n
    1. Kawaguchi T, Kitamura A, Kimura M, Rikitake Y, Iwao C, Iwao K, Sumiyoshi M, Kariya Y, Matsuda M, Umekita K, Takajo I, Moriguchi-Goto S, Yamashita A, Matsumoto K, Miyazaki T. Successful treatment of disseminated cryptococcosis with liposomal amphotericin B and isavuconazole in an adult living with HIV: A case report and literature review. J Infect Chemother. 2025;31:102534.<\/li>\n
    2. Ochiai K, Aoki Y, Yamada N, Aman M, Yamashita A, Yamaguchi M, Nakato D, Takenouchi T, Kosaki K, Kodama Y, Moritake H. Novel SKIC3 variants in tricho-hepato-enteric syndrome with hemochromatosis. Hum Genome Var. 2025;12:14.<\/li>\n
    3. Iwamoto K, Furukawa K, Meiri R, Iwasaki A, Mori K, Sakaguchi S, Uehara M, Isihi H, Maekawa K, Yamashita A. Surgery experience with calcified amorphous tumor of the mitral valve complicated by infective endocarditis. Surg Case Rep. 2025;11:25-0682.<\/li>\n
    4. Uchida A, Matsuura Y, Sakaguchi S, Furukawa K, Kaikita K. Unexpected migraine improvement following surgical ligation of the right superior vena cava drainage into the left atrium: a case report. Eur Heart J Case Rep. 2025;9:ytaf273.<\/li>\n
    5. Kawano T, Matsumoto F, Yamashita S, Oguri N, Akizuki K, Tomonaga T, Akiyama Y, Kadota Y, Oda Y, Azuma M, Yamashita A, Okita Y. Primary intracranial Ewing sarcoma arising from the cavernous sinus in an older woman with a history of intensive breast cancer treatment: A case report. NMC Case Rep J 2025:12;525-530.<\/li>\n<\/ol>\n

      \uff08\u7dcf\u8aac\u306a\u3069\uff09<\/strong><\/p>\n

        \n
      1. Yamashita A, Gi T, Sato Y. Histological differences among thrombi in thrombotic diseases. Curr Opin Hematol. 2025;32:146-156.<\/li>\n
      2. \u5c71\u4e0b\u3000\u7be4, \u524d\u5ddd\u548c\u4e5f. \u75c5\u5909\u4e0d\u5b89\u5b9a\u6027\u306b\u3064\u3044\u3066\u306e\u75c5\u7406\u5b66\u7684\u57fa\u790e\u77e5\u8b58. Coronary Intervention. 2025;21:13-17.<\/li>\n
      3. \u9b4f\u3000\u5cfb\u6d38. \u304c\u3093\u95a2\u9023\u8840\u6813\u75c7: \u4eba\u4f53\u75c5\u7406\u304b\u3089\u306e\u77e5\u898b. Thrombosis Medicine. 2025;15:161-167.<\/li>\n
      4. \u9b4f\u3000\u5cfb\u6d38, \u5c71\u4e0b\u3000\u7be4. \u8840\u6813\u75c7\u306e\u75c5\u7406\u8a3a\u65ad. \u533b\u5b66\u306e\u3042\u3086\u307f. 2025;294:677-682.<\/li>\n
      5. \u5c71\u4e0b\u3000\u7be4. \u6b62\u8840\u6a5f\u69cb\u3068\u9759\u8108\u8840\u6813\u5f62\u6210\u6a5f\u5e8f\u306e\u76f8\u9055: \u8840\u6db2\u51dd\u56faXI\u56e0\u5b50\u304b\u3089\u306e\u8996\u70b9. \u8840\u6813\u6b62\u8840\u8a8c. 2025;36:771-780.<\/li>\n<\/ol>\n

        \uff08\u5b66\u4f1a\u767a\u8868\uff09<\/strong><\/p>\n

          \n
        1. \u963f\u842c\u3000\u7d2b, \u9ed2\u6728\u9ebb\u7531, \u76db\u53e3\u6df8\u9999, \u90fd\u7bc9\u3000\u8ad2, \u732a\u702c\u5c06\u4e4b, \u4f50\u85e4\u52c7\u4e00\u90ce, \u843d\u5408\u79c0\u4fe1, \u5c71\u4e0b\u3000\u7be4. \u591a\u6570\u306e\u718a\u8702\u523a\u50b7\u306b\u3088\u308b\u76ae\u819a\u58ca\u6b7b\u30fb\u6a2a\u7d0b\u7b4b\u878d\u89e3\u75c7\u30fb\u3073\u307e\u3093\u6027\u80ba\u80de\u50b7\u5bb3\u3092\u6765\u3057\u305f1\u5256\u691c\u4f8b. \u7b2c114\u56de\u65e5\u672c\u75c5\u7406\u5b66\u4f1a\u7dcf\u4f1a\uff08\u4ed9\u53f0\u5e02, 4\/17-19, 2025\uff09<\/li>\n
        2. Nakamura E, Nishimura M, Maekawa K, Gi T, Oguri N, Aman M, Moriguchi-Goto S, Furukawa K, Yamashita A. Up-regulation of pyruvate kinase 2 and serine dehydratase in human aortic atherosclerosis and aneurysm. Vascular Discovery 2025 (Baltimore, 5\/22-25, 2025)<\/li>\n
        3. \u9b4f\u3000\u5cfb\u6d38, \u89e3\u3000\u51f1\u582f, \u5e64\u3000\u5149\u592a\u90ce, \u4e2d\u6751\u6075\u7406\u5b50, \u5927\u6817\u4f38\u884c, \u963f\u842c\u3000\u7d2b, \u76db\u53e3\u6df8\u9999, \u4e0b\u7530\u548c\u54c9, \u4e45\u7530\u6d0b\u5e73, \u5c71\u4e0b\u3000\u7be4. \u767d\u8840\u75c5\u306b\u5408\u4f75\u3059\u308b\u8133\u51fa\u8840\u306e\u75c5\u7406. \u7b2c47\u56de\u65e5\u672c\u8840\u6813\u6b62\u8840\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\uff08\u540d\u53e4\u5c4b\u5e02, 6\/27-29, 2025\uff09<\/li>\n
        4. \u4e2d\u6751\u6075\u7406\u5b50, \u897f\u6751\u5f81\u61b2, \u9b4f\u3000\u5cfb\u6d38, \u524d\u5ddd\u548c\u4e5f, \u76db\u53e3\u6df8\u9999, \u53e4\u5ddd\u8ca2\u4e4b, \u5c71\u4e0b\u3000\u7be4. \u5927\u52d5\u8108\u52d5\u8108\u786c\u5316\u5de3\u3084\u5927\u52d5\u8108\u7624\u306b\u304a\u3051\u308b\u30d4\u30eb\u30d3\u30f3\u9178\u30ad\u30ca\u30fc\u30bc2\u3068\u30bb\u30ea\u30f3\u30c7\u30d2\u30c8\u30e9\u30bf\u30fc\u30bc\u306e\u767a\u73fe\u3068\u5206\u5e03. \u7b2c57\u56de\u65e5\u672c\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\uff08\u3064\u304f\u3070\u5e02, 7\/5-6, 2025\uff09<\/li>\n
        5. Oguri N, Gi T, Nakamura E, Maekawa K, Furukoji E, Okawa H, Kouyama S, Horiuchi S, Sawaguchi A, Sakae T, Azuma M, Asada Y, Yamashita A. Factor XI localization in human venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit. The 5th Japan-China Joint Rabbit Bioscience Forum\uff08\u672d\u5e4c, 2025\/7\/11-13\uff09<\/li>\n
        6. \u5c71\u4e0b\u3000\u7be4, \u6749\u7530\u5343\u6cf0, \u524d\u5ddd\u548c\u4e5f, \u5927\u6817\u4f38\u884c. \u8840\u6db2\u51dd\u56faVIII\u56e0\u5b50\u306e\u5897\u52a0\u306f\u30d7\u30e9\u30fc\u30af\u3073\u3089\u3093\u306b\u3088\u308b\u8840\u6813\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\uff1a\u30a6\u30b5\u30ae\u5185\u819c\u80a5\u539a\u3073\u3089\u3093\u30e2\u30c7\u30eb\u306b\u3088\u308b\u691c\u8a0e. \u7b2c7\u56de\u30a6\u30b5\u30ae\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9\u7814\u7a76\u4f1a\uff08\u672d\u5e4c, 2025\/7\/11-13\uff09<\/li>\n
        7. \u76db\u53e3\u6df8\u9999, \u5c71\u4e0b\u3000\u7be4. \u91cd\u75c7\u71b1\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u8840\u5c0f\u677f\u6e1b\u5c11\u6a5f\u5e8f\u306e\u75c5\u614b\u89e3\u660e. \u7b2c168\u56de\u65e5\u672c\u7363\u533b\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\uff08\u5bae\u5d0e\u5e02, 9\/4, 2025\uff09<\/li>\n
        8. \u5185\u7530\u6681\u5b50, \u9db4\u7530\u654f\u535a. \u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08metabolic dysfunction associated steatotic liver disease; MASLD\uff09\u75c7\u4f8b\u306e\u8179\u90e8\u5927\u52d5\u8108MRI T1\u5f37\u8abf\u753b\u50cf\u9ad8\u4fe1\u53f7\u30d7\u30e9\u30fc\u30af\u306e\u691c\u51fa. \u7b2c47\u56de\u65e5\u672c\u9ad8\u8840\u5727\u5b66\u4f1a\u7dcf\u4f1a\uff08\u6771\u4eac, 10\/17-19, 2025\uff09<\/li>\n
        9. \u9b4f\u3000\u5cfb\u6d38, \u89e3\u3000\u51f1\u582f, \u5e64\u3000\u5149\u592a\u90ce, \u4e2d\u6751\u6075\u7406\u5b50, \u5927\u6817\u4f38\u884c, \u963f\u842c\u3000\u7d2b, \u76db\u53e3\u6df8\u9999, \u4e0b\u7530\u548c\u54c9, \u4e45\u7530\u6d0b\u5e73, \u5c71\u4e0b\u3000\u7be4. \u767d\u8840\u75c5\u7d30\u80de\u306e\u6d78\u6f64\u306b\u3088\u308b\u8133\u8840\u7ba1\u306e\u8106\u5f31\u6027\u306f\u8133\u51fa\u8840\u3068\u95a2\u9023\u3059\u308b. \u7b2c71\u56de\u65e5\u672c\u75c5\u7406\u5b66\u4f1a\u79cb\u671f\u7279\u5225\u7dcf\u4f1a\uff08\u540d\u53e4\u5c4b\u5e02, 11\/13-14, 2025\uff09<\/li>\n
        10. \u524d\u5ddd\u548c\u4e5f, \u6749\u7530\u5343\u6cf0, \u9b4f\u3000\u5cfb\u6d38, \u5927\u6817\u4f38\u884c, \u6d45\u7530\u7950\u58eb\u90ce, \u5c71\u4e0b\u3000\u7be4. \u8840\u6db2\u51dd\u56faVIII\u56e0\u5b50\u6d3b\u6027\u306e\u5897\u52a0\u306f\u30d7\u30e9\u30fc\u30af\u3073\u3089\u3093\u306e\u8840\u6813\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b. \u7b2c30\u56de\u65e5\u672c\u8840\u7ba1\u75c5\u7406\u7814\u7a76\u4f1a\uff08\u6771\u4eac, 11\/22-23, 2025\uff09<\/li>\n
        11. \u524d\u5ddd\u548c\u4e5f, \u5c71\u672c\u7d17\u5b50, \u5185\u7530\u6681\u5b50, \u677e\u6d66\u7950\u4e4b\u4ecb, \u6d77\u5317\u5e78\u4e00, \u5c71\u4e0b\u3000\u7be4. \u5fc3\u623f\u4e2d\u9694\u6b20\u640d\u306b\u3088\u308b\u80ba\u9ad8\u8840\u5727\u75c7\u306e1\u5256\u691c\u4f8b. \u7b2c30\u56de\u65e5\u672c\u8840\u7ba1\u75c5\u7406\u7814\u7a76\u4f1a\uff08\u6771\u4eac, 11\/22-23, 2025\uff09<\/li>\n<\/ol>\n

          \uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u306a\u3069\uff09<\/strong><\/p>\n

            \n
          1. \u5c71\u4e0b\u3000\u7be4. \u6df1\u90e8\u9759\u8108\u8840\u6813\u75c7\u3084\u51fa\u8840\u6027\u75c5\u614b\u306b\u304a\u3051\u308b\u7dda\u6eb6\u7cfb\u56e0\u5b50\u306e\u767a\u73fe. \u7b2c19\u56de\u65e5\u672c\u8840\u6813\u6b62\u8840\u5b66\u4f1a\u5b66\u8853\u6a19\u6e96\u5316\u59d4\u54e1\u4f1a\uff08\u6771\u4eac, 2\/15, 2025\uff09<\/li>\n
          2. \u5c71\u4e0b\u3000\u7be4. \u7ca5\u72b6\u52d5\u8108\u786c\u5316\u8840\u7ba1\u306e\u75c5\u7406\u3068\u8840\u6813. \u7b2c57\u56de\u65e5\u672c\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\uff08\u7b51\u6ce2, 7\/6, 2025\uff09<\/li>\n<\/ol>\n

            \uff08\u4e5d\u5dde\u30fb\u6c96\u7e04\u30b9\u30e9\u30a4\u30c9\u30b3\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\uff09<\/strong><\/p>\n

              \n
            1. \u524d\u5ddd\u548c\u4e5f. \u53f3\u8033\u4e0b\u817a\u816b\u760d\uff08Pleomorphic adenoma\uff09.
              \u7b2c405\u56de\uff08\u4e5d\u5dde\u5927\u5b66, \u798f\u5ca1\u5e02\uff09<\/li>\n
            2. \u5927\u6817\u4f38\u884c\uff1a\u5c0f\u8178\u75c5\u5909\uff08Multiple gastrointestinal stromal tumor, with diffuse hyperplasia of interstitial cells of Cajal\uff09.
              \u7b2c405\u56de\uff08\u4e5d\u5dde\u5927\u5b66, \u798f\u5ca1\u5e02\uff09<\/li>\n
            3. \u5927\u6817\u4f38\u884c\uff1a\u5b50\u5bae\u30fb\u5375\u5de3\u30fb\u5375\u7ba1\u816b\u760d\uff08Synchronous mucinous metaplasia and neoplasms of female genital tract\uff09.
              \u7b2c407\u56de\uff08\u4f50\u8cc0\u5927\u5b66, \u4f50\u8cc0\u5e02\uff09<\/li>\n<\/ol>\n

              \uff08\u4e5d\u5dde\u75c5\u7406\u96c6\u8ac7\u4f1a\uff09<\/strong><\/p>\n

                \n
              1. \u9b4f\u3000\u5cfb\u6d38. \u5927\u52d5\u8108\u7ca5\u72b6\u52d5\u8108\u786c\u5316\u75c7\u306b\u4f34\u3046\u5168\u8eab\u6027\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u585e\u6813\u75c7\u306e\u4e00\u5256\u691c\u4f8b.
                \u7b2c98\u56de\u96c6\u8ac7\u4f1a\uff08Web\u958b\u50ac, \u7409\u7403\u5927\u5b66\u4e3b\u5e79\uff09<\/li>\n<\/ol>\n

                \uff08\u53d7\u8cde\uff09<\/strong><\/p>\n

                  \n
                1. The 5th Japan-China Joint Rabbit Bioscience Forum, Young Investigator Award
                  \u5927\u6817\u3000\u4f38\u884c<\/li>\n
                2. \u533b\u5b66\u7814\u7a76\u8005\u80b2\u6210\u30b3\u30fc\u30b9\u7814\u7a76\u767a\u8868\u4f1a \u533b\u5b66\u90e8\u9577\u8cde
                  \u89e3\u3000\u51f1\u582f\uff08\u533b\u5b66\u79d15\u5e74\u751f\uff09<\/li>\n
                3. Pathology International High Citation Award\u3000\u5c71\u4e0b\u3000\u7be4<\/span><\/span><\/li>\n<\/ol>\n

                  \uff08\u5b66\u4f4d\u53d6\u5f97\uff09<\/strong><\/p>\n