{"id":1643,"date":"2024-10-14T22:29:15","date_gmt":"2024-10-14T13:29:15","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/?p=1643"},"modified":"2024-10-14T22:29:16","modified_gmt":"2024-10-14T13:29:16","slug":"the-journal-of-biochemistry%e3%81%ae%e7%b7%8f%e8%aa%ac%e3%81%ae%e7%b0%a1%e5%8d%98%e3%81%aa%e8%a7%a3%e8%aa%ac","status":"publish","type":"post","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/2024\/10\/14\/the-journal-of-biochemistry%e3%81%ae%e7%b7%8f%e8%aa%ac%e3%81%ae%e7%b0%a1%e5%8d%98%e3%81%aa%e8%a7%a3%e8%aa%ac\/","title":{"rendered":"The Journal of Biochemistry\u306e\u7dcf\u8aac\u306e\u7c21\u5358\u306a\u89e3\u8aac"},"content":{"rendered":"\n<p style=\"font-weight: 400\">\u6749\u5c71\u3067\u3059\u3002<\/p>\n<p style=\"font-weight: 400\">\u300c\u304a\u77e5\u3089\u305b\u300d\u306b\u306f\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u5c11\u3057\u524d\u306b\u3001Neurodegenerative diseases associated with the disruption of proteostasis and their therapeutic strategies using chemical chaperones\u3068\u3044\u3046\u30bf\u30a4\u30c8\u30eb\u3067\u3001\u30b7\u30e3\u30da\u30ed\u30f3\u7642\u6cd5\u306e\u307e\u3068\u3081\u3068\u65b0\u3057\u3044\u8003\u3048\u65b9\u306b\u3064\u3044\u3066\u795e\u7d4c\u75be\u60a3\u306e\u6cbb\u7642\u3068\u3044\u3046\u89b3\u70b9\u3092\u5165\u308c\u3066\u7dcf\u8aac\u3092\u66f8\u304d\u307e\u3057\u305f\u3002\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u306f\u3001\u82e5\u3044\u5973\u6027\u304c\u521d\u3081\u3066\u793e\u4ea4\u754c\u306b\u30c7\u30d3\u30e5\u30fc\u3059\u308b\u969b\u306b\u4ed8\u304d\u6dfb\u3046\u5e74\u4e0a\u306e\u5973\u6027\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u306b\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6b63\u3057\u304f\u6298\u308a\u305f\u305f\u307e\u308c\u3066\u6a5f\u80fd\u3092\u7372\u5f97\u3059\u308b\u306e\u3092\u624b\u52a9\u3051\u3059\u308b\u7269\u8cea\u306e\u7dcf\u79f0\u3067\u3059\u3002\u30b7\u30e3\u30da\u30ed\u30f3\u306f\u3001\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u3001\u85ac\u7406\u5b66\u7684\u30b7\u30e3\u30da\u30ed\u30f3\u3001\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u306e3\u3064\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u304c\u3001\u85ac\u7406\u5b66\u7684\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u306f\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306a\u306e\u3067\u3001\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3059\u308b\u306e\u3067\u795e\u7d4c\u75be\u60a3\u3078\u306e\u5fdc\u7528\u306b\u3082\u7740\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u3082\u3053\u308c\u307e\u3067\u306e\u57fa\u790e\u7814\u7a76\u3067\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u4e00\u3064\u3067\u3042\u308b4\u30d5\u30a7\u30cb\u30eb\u916a\u9178\uff084-PBA\uff09\u3092\u6271\u3063\u3066\u3044\u307e\u3057\u305f\u30024-PBA\u306f\u3001\u30bf\u30a6\u30eb\u30eb\u30bd\u30b8\u30aa\u30fc\u30eb\u3068\u306e\u5408\u5264\u304cALS\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u30a2\u30e1\u30ea\u30ab\u3067\u958b\u767a\u3055\u308c\u305f\u3082\u306e\u306e\u3001\u4eca\u5e74\u306e3\u6708\u306b\u7b2c3\u76f8\u3067\u6709\u610f\u306a\u5dee\u3092\u793a\u305b\u305a\u64a4\u9000\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u30014-PBA\u306e\u4f5c\u7528\u8d77\u7528\u6a5f\u5e8f\u306f\u8208\u5473\u6df1\u304f\u3001\u65b0\u3057\u3044\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u63a2\u7d22\u3059\u308b\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306f\u3001\u307e\u3060\u6709\u7528\u3067\u3042\u308b\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3042\u305f\u308a\u306f\u7dcf\u8aac\u306b\u8a73\u3057\u304f\u66f8\u304d\u307e\u3057\u305f\u3002\u30b7\u30e3\u30da\u30ed\u30f3\u7642\u6cd5\u3092\u307e\u3068\u3081\u305f\u65b0\u3057\u3044\u7dcf\u8aac\u306f\u3042\u307e\u308a\u306a\u3044\u306e\u3067\u3001\u826f\u304b\u3063\u305f\u3089\u53c2\u8003\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"\u6749\u5c71\u3067\u3059\u3002 \u300c\u304a\u77e5\u3089\u305b\u300d\u306b\u306f\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u5c11\u3057\u524d\u306b\u3001Neurodegenerative diseases associated with the disruption of proteostasis and th &#8230;","protected":false},"author":154,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false},"categories":[4],"tags":[],"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/posts\/1643"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/users\/154"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/comments?post=1643"}],"version-history":[{"count":1,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/posts\/1643\/revisions"}],"predecessor-version":[{"id":1644,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/posts\/1643\/revisions\/1644"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/media?parent=1643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/categories?post=1643"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/tags?post=1643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}