{"id":11,"date":"2018-09-07T09:25:13","date_gmt":"2018-09-07T00:25:13","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/?page_id=11"},"modified":"2025-05-14T01:46:43","modified_gmt":"2025-05-13T16:46:43","slug":"research","status":"publish","type":"page","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/research\/","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"<p>\u7814\u7a76\u3068\u306f\u81ea\u5206\u304c\u8208\u5473\u3092\u6301\u3064\u3053\u3068\u3092\u81ea\u7531\u306b\u7a81\u304d\u8a70\u3081\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u898f\u6a21\u306e\u5c0f\u3055\u3044\u5730\u65b9\u5927\u5b66\u3067\u306f\u5358\u72ec\u306e\u8a3a\u7642\u79d1\u3084\u8b1b\u5ea7\u3067\u81ea\u5206\u304c\u3084\u308a\u305f\u3044\u30c6\u30fc\u30de\u3092\u6df1\u304f\u8ffd\u6c42\u3059\u308b\u3053\u3068\u306f\u73fe\u5b9f\u7684\u306b\u56f0\u96e3\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u81ea\u5206\u305f\u3061\u306e\u6bbb\u306b\u9589\u3058\u3053\u3082\u3089\u305a\u3001\u57fa\u790e\u533b\u5b66\u306e\u7814\u7a76\u5ba4\u3084\u4ed6\u5b66\u90e8\u3068\u3082\u7a4d\u6975\u7684\u306b\u4ea4\u6d41\u3057\u3066\u5171\u540c\u7814\u7a76\u306e\u8f2a\u3092\u5e83\u3052\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u300c\u81ea\u7531\u306b\u3001\u81ea\u5206\u306e\u3084\u308a\u305f\u3044\u3053\u3068\u3092\u3001\u6df1\u304f\u8ffd\u6c42\u3059\u308b\u300d\u3068\u3044\u3046\u7814\u7a76\u3092\u884c\u3046\u4e0a\u3067\u57fa\u672c\u7684\u306a\u59ff\u52e2\u3092\u5927\u5207\u306b\u3057\u3066\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" class=\"alignnone size-full wp-image-1614\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/files\/2024\/10\/78692eb8438a92f7e11a516981ad7fad.gif\" alt=\"\" width=\"1280\" height=\"720\"><\/p>\n<p><\/p>\n<p><u><b>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u95a2\u3059\u308b\u7814\u7a76<\/b><\/u><\/p>\n<p>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306f\u672a\u3060\u306b\u5341\u5206\u306b\u75c5\u614b\u304c\u89e3\u660e\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u3082\u306e\u3070\u304b\u308a\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8\u6a5f\u80fd\u751f\u5316\u5b66\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u5c0f\u80de\u4f53\u95a2\u9023\u5206\u89e3\u306b\u95a2\u308f\u308bDerlin\u30d5\u30a1\u30df\u30ea\u30fc\u304c\u6b20\u640d\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u7d30\u80de\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u304c\u4f4e\u4e0b\u3057\u3066\u5c0f\u8133\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u8133\u840e\u7e2e\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3001\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b4\u30d5\u30a7\u30cb\u30eb\u916a\u9178\u304c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u4f4e\u4e0b\u3068\u8133\u840e\u7e2e\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306fALS\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u53c8\u3001\u5927\u5b66\u9662\u751f\u304c\u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8\u5fae\u751f\u7269\u5b66\u306b\u6240\u5c5e\u3057\u3066\u30d7\u30ea\u30aa\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u57fa\u790e\u7814\u7a76\u3082\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<p>\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n<ol>\n<li>Sugiyama T and Nishitoh, J Biochem. 2024<\/li>\n<li>Sugiyama T et al., Sci Rep. 2022<\/li>\n<li>Sugiyama T et al., iScience. 2021<\/li>\n<li>Nakazato Y et al., J Neurol Sci. 2015<\/li>\n<\/ol>\n<p><img loading=\"lazy\" class=\"alignnone size-full wp-image-1615\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/files\/2024\/10\/16b644d51d9196c8d6912f1cd86d32f3.gif\" alt=\"\" width=\"1280\" height=\"720\"><\/p>\n<p><\/p>\n<p><u><b>\u795e\u7d4c\u514d\u75ab\u306b\u95a2\u3059\u308b\u7814\u7a76<\/b><\/u><\/p>\n<p>\u8fd1\u5e74\u306e\u795e\u7d4c\u514d\u75ab\u5206\u91ce\u306b\u304a\u3051\u308b\u6cbb\u7642\u306e\u767a\u5c55\u306f\u51c4\u307e\u3058\u304f\u3001\u69d8\u3005\u306a\u5206\u5b50\u6a19\u7684\u85ac\u3092\u4f7f\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u300110\u5e74\u524d\u3067\u306f\u8003\u3048\u3089\u308c\u306a\u3044\u307b\u3069\u75be\u60a3\u306e\u6d3b\u52d5\u6027\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u307e\u3060\u591a\u767a\u6027\u786c\u5316\u75c7\u306a\u3069\u306e\u75c5\u614b\u89e3\u660e\u306f\u5341\u5206\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u6211\u3005\u306e\u4e2d\u304b\u3089\u3001\u56fd\u5185\u306b\u304a\u3051\u308b\u795e\u7d4c\u514d\u75ab\u5b66\u7684\u7814\u7a76\u306e\u5148\u7aef\u3092\u8d70\u3063\u3066\u3044\u308b\u5927\u962a\u5927\u5b66\u5206\u5b50\u795e\u7d4c\u79d1\u5b66\u306b\u56fd\u5185\u7559\u5b66\u3057\u3001\u5b9f\u9a13\u7684\u306b\u4e2d\u67a2\u795e\u7d4c\u306b\u708e\u75c7\u3092\u8a98\u5c0e\u3059\u308bEAE\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u3092\u5b66\u3073\u306b\u884c\u304d\u307e\u3057\u305f\u3002\u795e\u7d4c\u304b\u3089\u5206\u6ccc\u3055\u308c\u308bCCL2\u3068\u3044\u3046\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u30ea\u30f3\u30d1\u7403\u306e\u8a98\u5c0e\u306b\u95a2\u308f\u308b\u3068\u3044\u3046\u65b0\u3057\u3044\u77e5\u898b\u3092\u5831\u544a\u3057\u3001\u73fe\u5728\u306fEAE\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u63a2\u7d22\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n<p>\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n<p>1. Nakazato et al., Sci Rep. 2020<img loading=\"lazy\" class=\"size-full wp-image-1634 aligncenter\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/files\/2024\/10\/180ccaffa9e0d15aeb22033f64c00a1f.gif\" alt=\"\" width=\"1280\" height=\"720\"><\/p>\n\n\n<p><u><b>\u81e8\u5e8a\u795e\u7d4c\u751f\u7406\u304a\u3088\u3073\u795e\u7d4c\u75c7\u5019\u306e\u5b9a\u91cf\u306b\u95a2\u3059\u308b\u7814\u7a76<\/b><\/u><\/p>\n<p>\u4ee5\u524d\u304b\u3089\u5bae\u5d0e\u3067\u306f\u8133\u6ce2\u3084\u7b4b\u96fb\u56f3\u3068\u3044\u3063\u305f\u81e8\u5e8a\u795e\u7d4c\u751f\u7406\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3057\u305f\u304c\u3001\u77ac\u76ee\u53cd\u5c04\u3092\u5fdc\u7528\u3057\u3066\u5074\u5c48\u3092\u4f34\u3063\u305f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u75c7\u4f8b\u3067\u306f\u8133\u5e79\u6a5f\u80fd\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306f\u3001\u5bae\u5d0e\u5927\u5b66\u5de5\u5b66\u90e8\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u5f93\u6765\u306f\u5b9a\u6027\u7684\u3082\u3057\u304f\u306f\u534a\u5b9a\u91cf\u7684\u3067\u3057\u304b\u8a55\u4fa1\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u795e\u7d4c\u75c7\u5019\u3092\u5b9a\u91cf\u5316\u3067\u304d\u308b\u3088\u3046\u306a\u88c5\u7f6e\u3084\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n<ol>\n<li>Ishii N et al., J Neurol Sci. 2020<\/li>\n<li>Sugiyama T et al., J Clin Neurophysiol. 2018<\/li>\n<li>Sakai K et al., Epileptic Disord. 2018<\/li>\n<li>Hayashida T, Sugiyama T, Sakai K et al, Electronics. 2023<\/li>\n<\/ol>\n<div id=\"attachment_1616\" style=\"width: 1290px\" class=\"wp-caption aligncenter\"><img aria-describedby=\"caption-attachment-1616\" loading=\"lazy\" class=\"wp-image-1616 size-full\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/files\/2024\/10\/7abf54506ca08107f55066ae1795ae57.gif\" alt=\"\" width=\"1280\" height=\"720\" \/><p id=\"caption-attachment-1616\" class=\"wp-caption-text\">(https:\/\/www.densan-soft.co.jp\/work\/ai-furue\/)<\/p><\/div>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p><u><b>\u795e\u7d4c\u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76<\/b><\/u><\/p>\n<p>\u7d30\u83cc\u6027\u9ac4\u819c\u708e\u3092\u7b46\u982d\u3068\u3057\u305f\u795e\u7d4c\u611f\u67d3\u75c7\u306f\u9069\u5207\u306a\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u826f\u597d\u306a\u4e88\u5f8c\u304c\u671f\u5f85\u3067\u304d\u308b\u3082\u306e\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u4e00\u65b9\u3067\u6cbb\u7642\u306b\u305f\u3069\u308a\u7740\u304b\u305a\u3001\u81f4\u547d\u7684\u306b\u306a\u3063\u305f\u308a\u6df1\u523b\u306a\u6a5f\u80fd\u969c\u5bb3\u3092\u6b8b\u3057\u3066\u3057\u307e\u3063\u305f\u308a\u3059\u308b\u3082\u306e\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u6211\u3005\u306f\u3001\u7d30\u83cc\u6027\u9ac4\u819c\u708e\u75c7\u4f8b\u306e\u8133\u810a\u9ac4\u6db2\u4e2d\u3067LEAP2\u3068\u3044\u3046\u751f\u7406\u6d3b\u6027\u30da\u30d7\u30c1\u30c9\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3001\u7d30\u83cc\u6027\u9ac4\u819c\u708e\u306e\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u306a\u308a\u3046\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u306f\u795e\u7d4c\u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u30ec\u30b8\u30b9\u30c8\u30ea\u7814\u7a76\u3092\u7acb\u3061\u4e0a\u3052\u3066\u4e88\u5f8c\u306b\u95a2\u308f\u308b\u56e0\u5b50\u306e\u89e3\u6790\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<img loading=\"lazy\" class=\"wp-image-1637 alignright\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/files\/2024\/10\/fdebc0cf0d6c4032daade52d8ae493de.gif\" alt=\"\" width=\"362\" height=\"272\" \/><\/p>\n<p>\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n<ol>\n<li>Sakai K, et al., Brain Behav. 2021<\/li>\n<li>Sakai K, Nakazato Y, et al., Endocr J. 2025<\/li>\n<\/ol>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p><u><b>\u81e8\u5e8a\u75ab\u5b66\u306b\u95a2\u3059\u308b\u7814\u7a76<\/b><\/u><\/p>\n<p>\u6162\u6027\u7812\u7d20\u4e2d\u6bd2\u306f\u3001\u4e95\u6238\u6c34\u306a\u3069\u3092\u4ecb\u3057\u3066\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u73fe\u5728\u3067\u3082\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u5730\u57df\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5bae\u5d0e\u770c\u9ad8\u5343\u7a42\u753a\u306e\u571f\u5442\u4e45\u5730\u533a\u306b\u306f\u3001\u304b\u3064\u3066\u7812\u7d20\u9271\u5c71\u304c\u3042\u308a\u30011920\u5e74\u304b\u308940\u5e74\u9593\u3001\u4e9c\u7812\u9178\u30ac\u30b9\u306e\u98db\u6563\u306b\u3088\u308a\u6162\u6027\u7812\u7d20\u4e2d\u6bd2\u60a3\u8005\u304c\u751f\u3058\u307e\u3057\u305f\u3002\u5bae\u5d0e\u5927\u5b66\u8133\u795e\u7d4c\u5185\u79d1\u306f\u5bae\u5d0e\u770c\u3068\u5354\u529b\u3057\u30661973\u5e74\u304b\u308950\u5e74\u4ee5\u4e0a\u306b\u6e21\u308a\u3001\u3053\u306e\u5730\u533a\u306e\u4f4f\u6c11\u691c\u8a3a\u3092\u7d99\u7d9a\u3057\u3066\u6162\u6027\u7812\u7d20\u4e2d\u6bd2\u5f8c\u907a\u75c7\u306e\u7d4c\u904e\u3092\u8ffd\u3063\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306e\u4e2d\u3067\u3001\u6700\u7d42\u66b4\u9732\u304b\u308940\u5e74\u7d4c\u3063\u305f\u73fe\u5728\u306b\u304a\u3044\u3066\u3082\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u969c\u5bb3\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3084\u795e\u7d4c\u7dda\u7dad\u306e\u5f84\u306b\u3088\u308a\u7d4c\u904e\u304c\u7570\u306a\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\uff1c\u4ee3\u8868\u7684\u306a\u696d\u7e3e\uff1e<\/p>\n<ol>\n<li>Sugiyama 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Sci. 2019<\/li>\n<li>Ishii N et al., Arch Environ Contam Toxicol. 2018\n<div id=\"attachment_1620\" style=\"width: 1290px\" class=\"wp-caption alignnone\"><img aria-describedby=\"caption-attachment-1620\" loading=\"lazy\" class=\"wp-image-1620 size-full\" src=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/files\/2024\/10\/4b05685261ca540ed37c047e7227f61f-1.gif\" alt=\"\" width=\"1280\" height=\"720\" \/><p id=\"caption-attachment-1620\" class=\"wp-caption-text\">(https:\/\/www.pref.miyazaki.lg.jp\/kankyokanri\/kurashi\/shizen\/toroku.html)<\/p><\/div>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"\u7814\u7a76\u3068\u306f\u81ea\u5206\u304c\u8208\u5473\u3092\u6301\u3064\u3053\u3068\u3092\u81ea\u7531\u306b\u7a81\u304d\u8a70\u3081\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u898f\u6a21\u306e\u5c0f\u3055\u3044\u5730\u65b9\u5927\u5b66\u3067\u306f\u5358\u72ec\u306e\u8a3a\u7642\u79d1\u3084\u8b1b\u5ea7\u3067\u81ea\u5206\u304c\u3084\u308a\u305f\u3044\u30c6\u30fc\u30de\u3092\u6df1\u304f\u8ffd\u6c42\u3059\u308b\u3053\u3068\u306f\u73fe\u5b9f\u7684\u306b\u56f0\u96e3\u3067\u3059\u3002\u6211\u3005\u306f\u3001\u81ea\u5206\u305f\u3061\u306e\u6bbb\u306b\u9589\u3058\u3053\u3082\u3089\u305a\u3001\u57fa\u790e\u533b\u5b66\u306e\u7814 &#8230;","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false},"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/pages\/11"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":30,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":1673,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/pages\/11\/revisions\/1673"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/neurology\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}