{"id":1558,"date":"2026-08-19T14:05:09","date_gmt":"2026-08-19T05:05:09","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english-demo\/?page_id=252"},"modified":"2026-10-07T11:58:30","modified_gmt":"2026-10-07T02:58:30","slug":"cardiovascular-physiology","status":"publish","type":"page","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/departments\/laboratories\/cardiovascular-physiology\/","title":{"rendered":"Cardiovascular Physiology"},"content":{"rendered":"\n

Nozomi Watanabe, M.D., Ph.D.
cardio-phys@med.miyazaki-u.ac.jp
http:\/\/www.med.miyazaki-u.ac.jp\/home\/cardio-phys\/<\/u><\/a><\/strong><\/p>\n\n\n\n

Summary<\/h2>\n\n\n\n

Our laboratory focuses on clinical and translational research on cardiovascular dynamics, in collaboration with the Departments of Cardiology, Cardiovascular Surgery, Gynaecology, and Veterinary Medicine. We conduct translational research related to cardiovascular inflammation, cancer cell microenvironment, dermal wound healing, and Biomaterials-based therapeutics, using cultured cells and animal models.<\/p>\n\n\n\n

Research Projects<\/h2>\n\n\n\n
  1. ECHO-based Cardiovascular imaging<\/li>
  2. Role of microenvironment in cancer cell metabolism using animal models<\/li>
  3. MicroRNA targeted therapeutics in relation to cardio-vascular inflammation<\/li>
  4. Green nanotechnology-based drug delivery system<\/li><\/ol>\n\n\n\n

    Lab techniques<\/h2>\n\n\n\n
    1. Animal Cell culture<\/li>
    2. Molecular Biology techniques including PCR, Cell cycle analysis, Ligation, Transformation,  Transfection, EMSA, ChIP, RNA interference<\/li>
    3. General protein techniques including Western blotting, Immunoprecipitation, Zymography, Fibrinolysis, ELISA, Immunofluorescence<\/li>
    4. Preparation of biomaterial-collagen scaffold systems for dermal substitutes<\/li><\/ol>\n\n\n\n
      \"\"<\/figure><\/div>\n\n\n\n

      International collaboration<\/h2>\n\n\n\n
      1. University of Indonesia, Indonesia<\/li>
      2. Brawijaya University, Indonesia<\/li>
      3. NITTE University, Karnataka, India<\/li>
      4. VIT University, Vellore, India<\/li>
      5. JBAS college for women, Chennai, India<\/li><\/ol>\n\n\n\n

        Recent Publications<\/h2>\n\n\n\n
        1. Mid-Coronary Artery Wall Echogenicity Can Contribute to the Initial Diagnosis of Kawasaki Disease: Quantitative Measurements by Transthoracic Echocardiography. Yamashita N, Kodama Y, Irisa H, Ifuku T, Nakatani K, Uchiyama Y, Moritake H, Watanabe N., J Am Soc Echocardiogr. 2026. doi: 10.1016\/j.echo.2025.12.013<\/li>
        2. Left Ventricular Outflow Tract Obstruction Due to Accessory Mitral Valve Tissue: An Unusual Systolic Murmur in an Elderly Patient. Kurogi K, Taniguchi T, Matsuura Y, Yamamura Y, Watanabe N, Furukawa K, Kaikita K., JACC Case Rep. 2026. doi: 10.1016\/j.jaccas.2025.106288.<\/li>
        3. Usefulness of exercise stress echocardiography in a patient with unilateral pulmonary branch stenosis. Yokoyama R, Kodama Y, Takamura K, Takahashi M, Tanaka M, Watanabe N, Moritake H., J Cardiol Cases. 2025. doi: 10.1016\/j.jccase.2025.02.003.<\/li>
        4. Potential Effects of Mild Atrial Secondary Mitral Regurgitation in Patients With Isolated Atrial Fibrillation. Akashi J, Iwataki M, Nabeshima Y, Onoue T, Hayashi A, Tanaga T, Nishino S, Kimura T, Yano M, Watanabe N, Tsuda Y, Araki M, Shibata Y, Nishimura Y, Otsuji Y, Kataoka M., 2025. doi: 10.1161\/CIRCIMAGING.123.016239.<\/li>
        5. Mitral regurgitation improvement after successful atrial fibrillation ablation by using a 3D mapping system. Watanabe N, Ashikaga K., Ann Cardiothoracsrg. 2024. doi: 10.21037\/acs-2023-afm-0079.<\/li>
        6. Fluro-Protein C-Phycocyanin Docked Silver Nanocomposite Accelerates Cell Migration through NFkB Signaling Pathway. Madhyastha H, Madhyastha R, Chakraborty E, Banerjee K, Shah K, Nakajima Y, Chauhan NS, Sudhakaran SL, Ohe K, Muthukaliannan GK, Gopalakrishnan AV, Maruyama M, Watanabe N., Int. J. Mol. Sci. 2023. doi: 10.3390\/ijms24043184<\/li>
        7. Retinoic acid attenuates nuclear factor kappaB mediated induction of NLRP3 inflammasome. Purbasari B, Madhyastha R, Madhyastha H, Nurrahmah QI,Maruyama M, Nakajima Y, Kataoka H, Watanabe N., Pharmacological Reports. 2022. doi: 10.1007\/s43440-021-00321-4<\/li>
        8. <\/a> MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles. Madhyastha R, Madhyastha H, Nurrahmah QI, Purbasari B, Maruyama M & Nakajima Y., Inflammation. 2021. doi: 10.1007\/s10753-021-01415-0<\/li>
        9. Retinoic acid abrogates LPS-induced inflammatory response via negative regulation of NF-kappa B\/miR-21 signaling. Nurrahmah QI, Madhyastha R, Madhyastha H, Purbasari B, Maruyama M, Nakajima Y., Immunopharmacol Immunotoxicol. 2021. doi: 10.1080\/08923973.2021.1902348.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

          Nozomi Watanabe, M.D., Ph.D.cardio-phys@med.miyazaki-u.ac.jphttp:\/\/www.med.miyazaki-u.ac.jp\/home\/cardio-phys\/ … <\/p>\n

          Continue reading “Cardiovascular Physiology”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1545,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false},"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/pages\/1558"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/comments?post=1558"}],"version-history":[{"count":1,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/pages\/1558\/revisions"}],"predecessor-version":[{"id":1665,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/pages\/1558\/revisions\/1665"}],"up":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/pages\/1545"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/english\/wp-json\/wp\/v2\/media?parent=1558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}