Research in the Department of Urology prioritizes practical science that contributes to actual medical treatment. Postgraduate students in the department are also actively involved in research, and their studies can be found in prestigious international journals.
The department’s main areas of research are urogenital oncology and nephrogenesis, and we actively collaborate with individuals and groups involved in basic research. A quick look at the projects and publications listed below shows the department’s extensive involvement in basic and clinical studies.
Toshiyuki Kamoto, M.D., Ph.D.
Department of Urology
Faculty of Medicine
University of Miyazaki
Ongoing Research Projects
- Identifications of clinically relevant molecular markers for urogenital cancers
- Analysis for “failure of ureteric bud invasion (FUBI)”: Using a new model of renal agenesis in mice
- Analysis of DNA polymorphisms in carcinogenesis and progression of urogenital cancers
- Identifications of molecular mechanism in metastasis of urogenital cancer: Using animal model
- Basic molecular biology techniques (e.g., PCR, Cell cultures)
- Immunological examination (e.g., ELISA, Western blotting analysis)
- Morphological analysis (e.g., Scanning and transmission electron microscopy, Immunohistochemistry)
- Animal experiments
- Department of Urology, Kyoto University, Kyoto, Japan
- Laboratory Medicine, Faculty of Health Care, Tenri Health Care University, Nara, Japan
- Laboratory of Veterinary Biochemistry and Molecular Biology, Miyazaki University, Miyazaki, Japan
- Dysregulated HAI-2 plays an important role in renal cell carcinoma bone metastasis through ligand-dependent MET phosphorylation, Yamasaki K, Mukai S, Sugie S, Nagai T, Nakahara K, Kamibeppu T, Sakamoto H, Shibasaki N, Terada N, Toda Y, Kataoka H, Kamoto T. Cancers. 2018, 10(6)
- Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression., Sugie S, Mukai S, Yamasaki K, Kamibeppu T, Tsukino H, Kamoto T. Cancer Genomics Proteomics. 2015, 12(6):391-396.
- Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis., Mukai S, Yorita K, Kawagoe Y, Katayama Y, Nakahara K, Kamibeppu T, Sugie S, Tukino H, Kamoto T, Kataoka H. Hum Cell. 2015, 28(1):44-50
- Plasma macrophage-stimulating protein and hepatocyte growth factor levels are associated with prostate cancer progression., Sugie S, Mukai S, Yamasaki K, Kamibeppu T, Tsukino H, Kamoto T. Hum Cell. 2015, [Epub ahead of print], PMID:26250899.
- Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis., Mukai S, Yorita K, Yamasaki K, Nagai T, Kamibeppu T, Sugie S, Kida K, Onizuka C, Tsukino H, Kamimura T, Kamoto T, Kataoka H. Hum Cell. 2015, 28(3):133-142.
- Cyclooxygenase 2 Genotypes Influence Progression of Prostate Cancer Susceptibility in Japanese Men., Sugie S, Tsukino H, Mukai S, Akioka T, Shibata N, Nagano M, Kamoto T. Tumor Biology. 2014 Mar;35(3):2717-21. doi: 10.1007/s13277-013-1358-y.
- Effect of Dutasteride on Microvessel Density in Benign Prostatic Hyperplasia., Sugie S, Mukai S, Tsukino H, Iwamoto H, Kobayashi T, Toda Y, Kamoto T.In Vivo. 2014 May-June; 28(3):355-60.
- Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis., Mukai S, Yorita K, Kawagoe Y, Katayama Y, Nakahara K, Kamibeppu T, Sugie S, Tukino H, Kamoto T, Kataoka H. Hum Cell. 2014 Sep 4.
- Functional Polymorphism in the CAV1 T29107A Gene and Its Association with Prostate Cancer Risk among Japanese Men., Sugie S, Tsukino H, Yamauchi T, Mukai S, Fujii M, Shibata N, Kuroda Y, Kamoto T. Anticancer Res. 2013 Mar;33(3):1023-7.
- Increased Plasma Caveolin-1 Levels Are Associated with Progression of Prostate Cancer among Japanese Men., Sugie S, Mukai S, Tsukino H, Toda Y, Yamauchi T, Nishikata I, Kuroda Y, Morishita K, Kamoto T. Anticancer Res. 2013 May;33(5):1893-7.
- Analysis of multimodal treatment outcome in renal cell carcinoma patients with bone metastasis., Mukai S, Tsukino H, Goto T, Sugie S, Shitamura T, Kamimura T, Kamoto T. Hinyokika Kiyo. 2013 Apr;59(4):207-12. Japanese.