Faculty of Medicine University of Miyazaki


Dr. T Ikeda, PhD.


The release from pain and suffering may be important concern for human being. The World Health Organization defines pain as “an unpleasant sensory or emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Pain is also emotional experience while being sensory experience. There are a lot of questions that haven’t been answered in the mechanisms of the nervous system that is mediating between a noxious stimulation and pain. Particularly, our interest focuses on neuropathic pain may be due to a pathophysiological alteration of the peripheral and/or central nervous system including spinal dorsal horn neurons. The hallmarks of this type pain include an enhanced response to noxious stimuli (hyperalgesia), and a pain response to previously non-noxious stimuli (allodynia). “Is human being possible to be released from pain and suffering?” Please join our research for its important concern.

Research Projects

  1. Neurotransmitter and its receptors in synapse of spinal dorsal horn
  2. Expression of immediate early genes in spinal dorsal horn neurons after noxious stimulation
  3. Development of neuropathic pain
  4. Evaluation of antiallodynic effect mediated by descending pain control system

Research Techniques

  1. Preparing several animal models of neuropathic pain (e.g. chronic constriction injury of the sciatic nerve, diabetic neuropathy)
  2. Methods of behavioral pain test
  3. Immnostaining and morphological analysis
  4. Detection and analysis of proteins by western blotting


  1. The role of spinal serotonin receptor and alpha adrenoceptor on the antiallodynic effects induced by intrathecal milnacipran in chronic constriction injury rats. Nakamura et al. Eur J Pharmacol. 738: 57, 2014
  2. New tachykinin peptides and nociception. Nishimori et al. Jap Dental Sci Rev. 49: 27, 2013
  3. Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain. Ikeda et al. Neurosci Res. 63: 42, 2009