Our laboratory focuses on applied research on plasminogen activator system in cell migration and invasion, cancer cell microenvironment, dermal wound healing process and promotion; and Biomaterials -based therapeutics. We also study the impact of naturaceuticals on pathophysiological events, in both cellular and animal models.
- Role of microenvironment in cancer cell metabolism using animal models.
- MicroRNA targeted therapeutics in relation to chronic non-healing wounds.
- Biomaterials based drug delivery system.
- Nano-naturaceuticals in wound and osteoporosis management.
- Animal Cell culture
- Molecular Biology techniques including PCR, Cell cycle analysis, Ligation, Transformation, Transfection, EMSA, ChIP, RNA interference
- General protein techniques including Western blotting, Immunoprecipitation, Zymography, Fibrinolysis, ELISA, Immunofluorescence
- Preparation of biomaterial-collagen scaffold systems for dermal substitutes
- Department of Haematology, Prince of Songkla University, Thailand
- Indian Institute of Technology, Kanpur, India
- Indian Council of Medical Research, Bhopal, India
- NFkappaB activation is essential for miR-21 induction by TGFb1 in high glucose conditions. Madhyastha R., et al., BBRC 2014 (in press)
- Regional differences of microglial accumulation within 72 hours of hypoxia-ischemia and the effect of acetylcholine receptor agonist on brain damage and microglial activation in new-born rats. Furukawa S., et al., Brain Research 2014 (in press)
- MicroRNA signature in diabetic wound healing: promotive role of miR-21 in fibroblast migration. Madhyastha R., et al., International Wound Journal 2012; 9: 355-361.