{"id":69,"date":"2014-06-12T08:55:51","date_gmt":"2014-06-11T23:55:51","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/?p=69"},"modified":"2026-04-27T11:27:03","modified_gmt":"2026-04-27T02:27:03","slug":"yoshitaka-hishikawa","status":"publish","type":"post","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/yoshitaka-hishikawa\/","title":{"rendered":"Yoshitaka Hishikawa"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n
\n
Current position<\/strong>:<\/span><\/div>\n<\/td>\n
Professor, Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki<\/span><\/td>\n<\/tr>\n
\n
Academic degree<\/strong>:<\/span><\/div>\n<\/td>\n
MD., Ph.D, Certified surgeon of Japan Surgical Society <\/span><\/td>\n<\/tr>\n
\n
Biography<\/strong>:<\/span><\/div>\n<\/td>\n
\n
\n

1989
\n1989<\/span><\/p>\n

1996<\/span>
\n1998<\/span><\/p>\n

1999<\/span><\/p>\n

1999<\/span>
\n2005<\/span>
\n2011<\/span>
\n2021<\/span><\/p>\n<\/div>\n<\/td>\n

Shimane Medical University, School of Medicine
\nHospital resident physician, Shimane Medical University, School of Medicine (Surgery II)
\nShimane Medical University, School of Medicine
\nAssistant professor, Shimane Medical University, School of Medicine<\/span>
\n (Surgery II)
\nAssistant professor, Nagasaki University, School of Medicine
\n(Department of Histology and Cell Biology)
\nLecturer<\/span>
\n Associate professor<\/span>
\nProfessor of University of Miyazaki (Division of Histochemistry and Cell Biology)<\/span>
\nDean, School of Medicine, University of Miyazaki (~Sep. 2024)<\/span>
\n<\/span><\/td>\n<\/tr>\n
\n
Specialty<\/strong>:<\/span><\/div>\n<\/td>\n
Histochemistry and Cell Biology<\/span><\/td>\n<\/tr>\n
\n
Society<\/strong>:<\/span><\/div>\n<\/td>\n
Japanese Association of Anatomists (councilor), Japan Society of Histochemistry and Cytochemistry (councilor), Japan Society for Clinical Molecular Morphology (councilor) Japanese Society of Microsopy, Japanese Cancer Association, Japan Surgical Society and others.<\/span><\/td>\n<\/tr>\n
\n
Research interest<\/strong>:<\/span><\/div>\n<\/td>\n
Mitochondrial controlling mechanism of the cell<\/span><\/td>\n<\/tr>\n
\n
Publication<\/strong>:<\/span><\/div>\n<\/td>\n
Fidya, Ishizuka T, Kubota T, Kai K, Hishikawa Y<\/strong>.\u00a0The Crucial Role of GPR30 and Histone Crotonylation during the Inflammatory Repair Process in Ligature-Induced Periodontitis. Acta Histochem. Cytochem. <\/strong>2026, 59(2):89-99. doi: 10.1267\/ahc.26-00002.<\/p>\n

Kai K, Ishizuka T, Matsumoto J, Shimamawari K, Mori R, Fidya, Lkham-Erdene B, Kubota T, Ikenoue M, Higuchi K, Nanashima A, Hishikawa Y<\/strong>. Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27.\u00a0Acta Histochem. Cytochem.<\/strong> 2025, 58(2):69-79. doi: 10.1267\/ahc.25-00002.<\/p>\n

Higuchi K, Ikenoue M, Ishizuka T, Kai K, Takahashi N, Kubota T, Shirouzu S, Lkham-Erdene B,\u00a0 <\/span>Mo Aung K, Nakai M, Sawaguchi A, Nanashima A, Hishikawa Y.<\/strong> SETDB1-mediated chromatin regulation in intestinal epithelial cells during intestinal ischemia-reperfusion injury. Acta Histochem. Cytochem. <\/strong>2025, 58 (1): 9-18. doi: 10.1267\/ahc.24-00061.\u3010Doctoral degree\u3011<\/span><\/p>\n

Lkham-Erdene B, Choijookhuu N, Kubota T, Uto T, Mitoma S, Shirouzu S, Ishizuka T, Kai K, Higuchi K, Mo Aung K, Batmunkh JE, Sato K, Hishikawa Y<\/strong>.\u00a0 Effect of hepatic lipid overload on accelerated hepatocyte proliferation promoted by HGF expression via the SphK1\/S1PR2 pathway in MCD\u2013diet mouse partial hepatectomy. Acta Histochem. Cytochem.<\/strong> 2024, 57(5): 175-188. doi: 10.1267\/ahc.24-00046.<\/p>\n

Choijookhuu N, Yano K, Lkham-Erdene B, Shirouzu S, Kubota T, Fidya, Ishizuka T, Kai K, Chosa E, Hishikawa Y.<\/strong> HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration. J. Histochem. Cytochem.<\/strong> 2024 Apr;72(4):245-264. doi: 10.1369\/00221554241241569.<\/p>\n

Ikenoue M, Choijookhuu N, Yano K, Fidya, Takahashi N, Ishizuka T, Shirouzu S, Yamaguma Y, Kai K, Higuchi K, Sawaguchi A, Nanashima A, Hishikawa Y.<\/strong> The crucial role of SETDB1 in structural and functional transformation of epithelial cells during regeneration after intestinal ischemia reperfusion injury. Histochem. Cell Biol.<\/strong> 2024 Apr;161(4):325-336. doi: 10.1007\/s00418-023-02263-9.\u3010Doctoral degree\u3011<\/span><\/p>\n

Fidya, Choijookhuu N, Ikenoue M, Yano K, Yamaguma Y, Shirouzu S, Kai K, Ishizuka T, Hishikawa Y.<\/strong> Protective role of estrogen through G-protein coupled receptor 30 in a colitis mouse model. Histochem. Cell Biol.<\/strong> 2024 Jan;161(1):81-93. doi: 10.1007\/s00418-023-02235-z.\u3010Doctoral degree\u3011<\/span><\/p>\n

Nagai T, Sekimoto T, Kurogi S, Ohta T, Miyazaki S, Yamaguchi Y, Tajima T, Chosa E, Imasaka M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Sato K, Hishikawa Y<\/strong>, Funamoto T. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Sci Rep.<\/strong> 2023 Sep 5;13(1):14639. doi: 10.1038\/s41598-023-41837-4.\u3010Doctoral degree\u3011<\/span><\/p>\n

Kai K, Nakashima K, Kawakami H, Takeno S, Hishikawa Y<\/strong>, Ikenoue M, Hamada T, Imamura N, Shibata T, Noritomi T, Sasaki F, Nakamura Y, Nanashima A. Clinical Impact of the Charlson Comorbidity Index on the Efficacy of Salvage Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer. Intern Med.<\/strong> 2023 Aug 9. doi: 10.2169\/internalmedicine.1907-23.<\/p>\n

Uto T, Fukaya T, Mitoma S, Nishikawa Y, Tominaga M, Choijookhuu N, Hishikawa Y<\/strong>, Sato K. Clec4A4 Acts as a Negative Immune Checkpoint Regulator to Suppress Antitumor Immunity. Cancer Immunol Res.<\/strong> 2023 Sep 1;11(9):1266-1279. doi: 10.1158\/2326-6066.CIR-22-0536.<\/p>\n

Nakamura T, Sakaguchi H, Mohri H, Ninoyu Y, Goto A, Yamaguchi T, Hishikawa Y<\/strong>, Matsuda M, Saito N, Ueyama T. Dispensable role of Rac1 and Rac3 after cochlear hair cell specification. J Mol Med.<\/strong> 2023 Jul;101(7):843-854. doi: 10.1007\/s00109-023-02317-4.<\/p>\n

Fukaya T, Uto T, Mitoma S, Takagi H, Nishikawa Y<\/strong>, Tominaga M, Choijookhuu N, Hishikawa Y, Sato K. Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells. Cell Rep.<\/strong> 2023 May 30;42(5):112431. doi: 10.1016\/j.celrep.2023.112431.<\/p>\n

Kai K, Hiyoshi M, Imamura N, Hamada T, Yano K, Sato Y, Sakae T, Komi M, Nakamura T, Choijookhuu N, Hishikawa Y<\/strong>, Nanashima A. A Preliminary Pathological Evaluation of Extracellular Volume Fraction with Contrast-enhanced Computed Tomography as a Novel Quantitative Parameter of Pancreatic Fibrosis. Intern Med.<\/strong> 2023;62(8):1107-1115. doi: 10.2169\/internalmedicine.0410-22.<\/p>\n

Kai K, Hamada T, Sato Y, Hiyoshi M, Imamura N, Yano K, Ikeda T, Ichihara A, Ogata S, Choijookhuu N, Hishikawa Y<\/strong>, Hosokawa A, Nanashima A. Extracellular Volume Fraction Calculated Using Contrast-Enhanced Computed Tomography as a Biomarker of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: A Preliminary Histopathological Analysis. J Oncol.<\/strong> 2023 Feb 14;2023:1440257. doi: 10.1155\/2023\/1440257.\u3010Doctoral degree\u3011<\/span><\/p>\n

Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, Ishizuka T, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C and Hishikawa Y.<\/strong> Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. J Ovarian Res.<\/strong> 2022, 15, 133. doi: 10.1186\/s13048-022-01071-4.\u3010Doctoral degree\u3011<\/span><\/p>\n

He Z, Ishizuka T, Hishikawa Y<\/strong>, Xu Y. Click chemistry for fluorescence imaging via combination of a BODIPY-based \u2018turn-on\u2019 probe and a norbornene glucosamine. Chem. Commun.<\/strong> 2022, 58, 12479-12482. doi:10.1039\/D2CC05359D.<\/p>\n

Choijookhuu N, Shibata Y, Ishizuka T, Xu Y, Koji T, Hishikawa Y<\/strong>. An advanced detection system for in situ hybridization using a fluorescence resonance energy transfer\u2013based molecular beacon probe. Acta Histochem. Cytochem.<\/strong> 2022, 55, 119-128. doi: 10.1267\/ahc.22-00075.<\/p>\n

Yano K, Choijookhuu N, Ikenoue M, Fidya, Fukaya T, Sato K, Lee D, Taniguchi N, Chosa E, Nanashima A, Hishikawa Y<\/strong>. Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration. Sci. Rep.<\/strong> 2022 12:11962. doi: 10.1038\/s41598-022-16258-4.\u3010Doctoral degree\u3011<\/span><\/p>\n

Miyazaki S, Funamoto T, Sekimoto T, Kurogi S, Ohta T, Nagai T, Tajima T, Imasaka M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Hishikawa Y<\/strong>, Chosa E. EPLIN\u03b2 Is Involved in the Assembly of Cadherin-catenin Complexes in Osteoblasts and Affects Bone Formation. Acta Histochem. Cytochem.<\/strong> 2022 55(3):99-110. doi: 10.1267\/ahc.22-00027.\u3010Doctoral degree\u3011<\/span><\/p>\n

Yamaguma Y, Sugita N, Choijookhuu N, Yano K, Lee D, Ikenoue M, Fidya, Shirouzu S, Ishizuka T, Tanaka M, Yamashita Y, Chosa E, Taniguchi N, Hishikawa Y<\/strong>.\u00a0 Crucial role of high-mobility group box 2 in mouse ovarian follicular development through estrogen receptor beta. Histochem. Cell Biol<\/strong>. 2022 157:359\u2013369 doi: 10.1007\/s00418-022-02074-4.\u3010Doctoral degree\u3011<\/span>
\n<\/span><\/p>\n

Hishikawa Y<\/strong>, Takizawa T, Koji T. In focus in HCB: new histochemical insights into mammalian gametogenesis. Histochem. Cell Biol.<\/strong> 2022 157(3):269-271. doi: 10.1007\/s00418-022-02083-3.<\/p>\n

Nishikawa Y, Fukaya T, Fukui T, Uto T, Takagi H, Nasu J, Miyanaga N, Riethmacher D, Choijookhuu N, Hishikawa Y<\/strong>, Amano M, Sato K.<\/span>\u00a0Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation. Front Immunol.<\/strong> 2021 Jul 27;12:712676. doi: 10.3389\/fimmu.2021.712676. eCollection 2021.<\/span><\/p>\n

Sawaguchi A, Kamimura T, Takahashi N, Yamashita A, Asada Y, Imazato H, Aoyama F, Wakui A, Sato T, Choijookhuu N, Hishikawa Y<\/strong>. <\/span>In situ strategy for biomedical target localization via nanogold nucleation and secondary growth. Commun Biol. 2021 4:710. doi: 10.1038\/s42003-021-02246-3.<\/span><\/p>\n

Miyanaga N, Takagi H, Uto T, Fukaya T, Nasu J, Fukui T, Nishikawa Y, Sparwasser T, Choijookhuu N, Hishikawa Y<\/strong>, Nakamura T, Tono T, and Sato K.: Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Commun. Biol. 2020 2020 Dec 7;3(1):742. doi: 10.1038\/s42003-020-01466-3.<\/p>\n

Mai NNH, Yamaguchi Y, Choijookhuu N, Matsumoto J, Nanashima A, Takagi H, Sato K, Tuan LQ, Hishikawa Y<\/strong>.: Photodynamic Therapy Using a Novel Phosphorus Tetraphenylporphyrin Induces an Anticancer Effect via Bax\/Bcl-xL-related Mitochondrial Apoptosis in Biliary Cancer Cells. Acta Histochem. Cytochem.<\/em> 2020, 53 (4) 61-72 DOI: 10.1267\/ahc.20-00002 \u3010Doctoral degree\u3011<\/span><\/p>\n

Fukui T, Fukaya T, Uto T, Takagi H, Nasu J,\u00a0Miyanaga N,\u00a0Nishikawa Y,\u00a0Koseki H,\u00a0Choijookhuu N, Hishikawa Y<\/strong>, Yamashita Y, Sato K.: Pivotal Role of CD103 in the Development of Psoriasiform Dermatitis. Sci. Rep<\/em>. 2020 May 20;10(1):8371. doi: 10.1038\/s41598-020-65355-9<\/p>\n

Diep NV, Choijookhuu N, Fuke N, Myint O, Izzati UZ, Suwanruengsri M, Hishikawa Y<\/strong>, Yamaguchi R.:\u00a0New Tropisms of Porcine Epidemic Diarrhoea Virus (PEDV) in Pigs Naturally Coinfected by Variants Bearing Large Deletions in the Spike (S) Protein and PEDVs Possessing an Intact S Protein.\u00a0Transbound. Emerg. Dis.<\/em> 2020 May DOI: 10.1111\/tbed.13607\u3010Doctoral degree\u3011<\/span><\/p>\n

Palasin K, Uechi T, Yoshihama M, Srisowanna N, Choijookhuu N, Hishikawa Y<\/strong>, Kenmochi N, Chotigeat W.:\u00a0Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a.\u00a0Sci. Rep.<\/em> 2019, doi.org\/10.1038\/s41598-019-54544-w<\/p>\n

Phyu KP, Zin PW, Aung MN, Lar MM, Hishikawa Y, Maruyama M, Yokota H, Thant KZ, Wai KT, Yano Y.: Contamination of arsenic in drinking water in Ayeyarwady delta region, Myanmar. World Journal of Pharmaceutical and Life Sciences<\/strong>. 2019 5(8):42-48<\/p>\n

Srisowanna N, Choijookhuu N, Yano K, Batmunkh B, Ikenoue M, Mai NNH, Yamaguchi Y and Hishikawa Y<\/strong>.: The effect of estrogen on hepatic fat accumulation during early phase of liver regeneration after partial hepatectomy in rats. Acta Histochem. Cytochem<\/strong>. 2019, 52 (4)1-9\u00a0doi.org\/10.1267\/ahc.19018 \u3010Doctoral degree\u3011<\/span><\/p>\n

Mochizuki H, Phyu KP, Aung MN, Zin PW, Yano Y, Myint MZ, Thit WM, Yamamoto Y, Hishikawa Y<\/strong>, Thant KZ, Maruyama M, Kuroda Y.: Peripheral neuropathy induced by drinking water contaminated with low-dose arsenic in Myanmar. Environ Health Prev Med.<\/strong> 2019 Apr 23;24(1):23. doi: 10.1186\/s12199-019-0781-0.<\/p>\n

Kyaw MTH, Yamaguchi Y, Choijookhuu N, Yano K, Takagi H, Takahashi N, Oo PS, Sato K, Hishikawa Y<\/strong>.: The HDAC Inhibitor, SAHA, Combined with Cisplatin Synergistically Induces Apoptosis in Alpha-fetoprotein-producing Hepatoid Adenocarcinoma Cells. Acta Histochem. Cytochem.<\/strong> 2019, 52:1-8 \u3010Doctoral degree\u3011<\/span><\/p>\n

Fukaya T, Fukui T, Uto T, Takagi H, Nasu J, Miyanaga N, Arimura K, Nakamura T, Koseki H, Choijookhuu N, Hishikawa Y<\/strong>, Yamashita Y, Sato K.: Pivotal role of IL-22BP in the epithelial autoregulation of IL-22 signaling in the control of skin inflammation. Frontiers. Immunol<\/strong>. 2018 Jun 21;9:1418. doi: 10.3389\/fimmu.2018.01418. eCollection 2018<\/p>\n

Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y<\/strong>, Kataoka H, Morinaga H, Lotz M Chosa E.: HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles. Sci. Rep<\/strong>. 2018, doi:10.1038\/s41598-018-28023 \u3010Doctoral degree\u3011<\/span><\/p>\n

Ali MN, Choijookhuu N, Takagi H, Srisowanna N, Huynh MNH, Yamaguchi Y, Oo PS, Kyaw MTH, Sato K, Yamaguchi R,\u00a0 Hishikawa Y.:<\/strong> The HDAC Inhibitor, SAHA, Prevents Colonic Inflammation by Suppressing Pro-inflammatory Cytokines and Chemokines in DSS-induced Colitis. Acta Histochem. Cytochem<\/strong>. 2018, 51:33-40\u3010Doctoral degree\u3011<\/span><\/p>\n

Oo PS, Yamaguchi Y, Sawaguchi A, Kyaw MTH, Choijookhuu N, Ali MN, Srisowanna N, Hino SI, Hishikawa Y<\/strong>.: Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells. Acta Histochem. Cytochem<\/strong>.2018, 51:21-31\u3010Doctoral degree\u3011<\/span><\/p>\n

Uto T, Takagi H, Fukaya T, Nasu J, Fukui T, Miyanaga N, Arimura K, Nakamura T, Choijookhuu N, Hishikawa Y,<\/strong> Sato K.: Critical role of plasmacytoid dendritic cells in induction of oral tolerance.\u00a0Journal of Allergy and Clinical Immunology. <\/strong>2018 141:2156-2167<\/p>\n

Matsumoto J, Suzuki K, Yasuda M, Yamaguchi Y, Hishikawa Y<\/strong>, Imamura N, Nanashima A.: Photodynamic therapy of human biliary cancer cell line using combination of phosporus porphyrins and light emitting diode. Bioorganic & Medicinal Chemistry.<\/strong> 2017, 25:6536-6541<\/p>\n

Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y<\/strong><\/span>, Kiyonari H, Kohta M, Sakahara M, de Curtis I, Kohmura E, Hisa Y, Aiba A, Saito N.: Novel role of Rac-Mid1 signaling in medial cerebellar development. Development<\/span>. 2017, 144:1863-1875<\/p>\n

Honda A, Choijookhuu N, Izu H, Kawano Y, Inokuchi M, Honsho K, Lee AR, Nabekura H, Ohta H, Tsukiyama T, Ohinata Y, Kuroiwa A, Hishikawa Y<\/strong><\/span>, Saitou M, Jogahara T, Koshimoto C.: Flexible adaptation of male germ cells from female iPSCs of endangered Tokudaia osimensis<\/i>. Sci Adv<\/span>. 2017 May 12;3(5):e1602179. doi: 10.1126\/sciadv.1602179<\/p>\n

Honda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M, Sankai T, Hishikawa Y<\/strong><\/span>, Ogura A, Saitou M.: Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Na\u00efve Conversion. Sci Rep<\/span>. Mar 28;7:45285. doi: 10.1038\/srep45285. (In Press) 2017<\/p>\n

Batmunkh B, Choijookhuu N, Srisowanna N, Byambatsogt U, Oo PS, Ali MN, Yamaguchi Y, Hishikawa Y<\/strong><\/span>.: Estrogen accelerates cell proliferation through estrogen receptor alpha during rat liver regeneration after partial hepatectomy. Acta Histochem. Cytochem. 2017 \u3010Doctoral degree\u3011<\/span><\/p>\n

Tsuchiya K, Ikeda T, Batmunkh B, Choijookhuu N, Ishizaki H, Hotokezaka M, Hishikawa Y<\/strong><\/span> Nanashima A.: Frequency of CD4+CD161+ T cell and interleukin-10 expression in inflammatory bowel diseases. Acta Histochem. Cytochem. 2017 \u3010Doctoral degree\u3011<\/span><\/p>\n

Chayapong J, Madhyastha H, Madhyastha R, Nurrahmah QI, Nakajima Y, Choijookhuu N, Hishikawa Y<\/span><\/strong>, Maruyama M.: Arsenic trioxide induces ROS activity and DNA damage, leading to G0\/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway. Environ Sci Pollut Res<\/strong><\/em> Int. 2016 Dec 24. DOI 10.1007\/s11356-016-8215-7 \u3010Doctoral degree\u3011<\/span><\/p>\n

Arimura K, Takagi H, Uto T, Fukaya T, Nakamura T, Choijookhuu N, Hishikawa Y<\/strong><\/span>, Yamashita Y, Sato K.: Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation Mucosal Immunol<\/em><\/strong>. 2016 Nov 16. doi: 10.1038\/mi.2016.96. \u3010Doctoral degree\u3011<\/span>
\n<\/span><\/p>\n

Takagi H, Arimura K, Uto T, Fukaya T, Nakamura T, Choijookhuu N, Hishikawa Y<\/strong><\/span>, Sato K.: Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation. Sci Rep<\/em><\/strong>. 2016 Apr. doi: 10.1038\/srep24477<\/span><\/p>\n

Yamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y<\/span><\/strong>, Pengjam Y, Nakajima Y, Maruyama M.: Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. J Toxicol Sci<\/em><\/strong>. 41:105-113, 2016 \u3010Doctoral degree\u3011<\/span>
\n<\/span><\/p>\n

Choijookhuu N, Hino SI, Oo PS, Batmunkh B, Hishikawa Y<\/strong><\/span>.: The role of estrogen receptors in intestinal homeostasis and disease. Receptors Clin Investig<\/strong><\/em>. 2016 Vol 3, No 1; doi: 10.14800\/rci.1109<\/span><\/p>\n

Muraoka I, Takatsuki M, Sakai Y, Tomonaga T, Soyama A, Hidaka M, Hishikawa Y<\/strong>, Koji T, Utoh R, Ohashi K, Okano T, Kanematsu T, Eguchi S.: Transplanted fibroblast cell sheets promote migration of hepatic progenitor cells in the incised host liver in allogenic rat model. J Tissue Eng Regen Med<\/strong><\/em>. 11:E108-115,\u00a02015.<\/span><\/p>\n

Choijookhuu N, Hino SI, Oo PS, Batmunkh B, Ali MN, Kyaw MTH, Hishikawa Y<\/strong>.: Ontogenetic changes in the expression of estrogen receptor\u00a0\u03b2 in mouse duodenal epithelium. Clin Res Hepatol Gastroenterol<\/strong><\/em>. 39, 499-507, 2015<\/span><\/p>\n

Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y<\/strong>, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N.: Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells. J Cell Sci<\/strong><\/em>. 127:2040\u20132052, 2014<\/span><\/p>\n

Nakajima K, Shibata Y, Hishikawa Y<\/strong>, Suematsu T, Mori M, Fukuhara S, Koji T, Sawase T, Ikeda T.: Coexpression of Ang1 and Tie2 in Odontoblasts of Mouse Developing and Mature Teeth-A New Insight into Dentinogenesis. Acta Histochem. Cytochem<\/strong><\/em>. 47: 19\u201325, 2014<\/span>
\n
\n<\/span>An S, Soe K, Akamatsu M, Hishikawa Y<\/span><\/strong>, Koji T.: Accelerated proliferation of hepatocytes in rats with iron overload after partial hepatectomy. Histochem Cell Biol.<\/em><\/strong>138: 773-786, 2012. <\/span><\/p>\n

Choijookhuu N, Sato Y, Nishino T, Endo D, Hishikawa Y<\/span><\/strong>, Koji T.: Estrogen-dependent regulation of sodium\/hydrogen exchanger-3 (NHE3) expression via estrogen receptor \u03b2 in proximal colon of pregnant mice. Histochem Cell Biol.<\/em><\/strong>137:575-587, 2012. <\/span><\/p>\n

Kitamura M, Nishino T, Obata Y, Furusu A, Hishikawa Y<\/span><\/strong>, Koji T, Kohno S.: Epigallocatechin gallate suppresses peritoneal fibrosis in mice. Chemico-Biological Interactions<\/em><\/strong> 195: 95-104, 2012<\/span>.<\/p>\n

Song N, Liu J, An S, Nishino T, Hishikawa Y<\/span><\/strong>, Koji T.: Immunohistochemical analysis of histone H3 modifications in germ cells during mouse spermatogenesis. Acta Histochem. Cytochem<\/em><\/strong>. 44:183-190, 2011.<\/span><\/p>\n

Yamamoto-Fukuda T, Hishikawa Y<\/span><\/strong>, Shibata Y, Kobayashi T, Takahashi H, Koji T.: Pathogenesis of middle ear cholesteatoma; a new model of experimentally induced cholesteatoma in mongolian gerbils. Am. J. Pathol.<\/strong><\/em> 176:2602-2606, 2010.<\/span><\/p>\n

Koji T, Kondo S, Hishikawa Y<\/span><\/strong>, An S, Sato Y.: In situ detection of methylated DNA by histo endonuclease-linked detection of methylated DNA sites: a new principle of analysis of DNA methylation. Histochem. Cell Biol.<\/em><\/strong> 130:917-925, 2008. <\/span><\/p>\n

Nakagawa T, Kajitani T, Togo S, Masuko N, Ohdan H, Hishikawa Y<\/span><\/strong>, Koji T, Matsuyama T, Ikura T, Muramatsu M, Ito T.: Deubiquitylation of histone H2A activates transcriptional initiation via trans<\/em>-histone cross-talk with H3K4 di- and trimethylation. Gene Dev.<\/em><\/strong> 22:37-49, 2008. <\/span><\/p>\n

Soe K, Hishikawa Y<\/span><\/strong>, Fukuzawa Y, Win N, Yin KS, Win KM, Myint AA, Koji T.: Possible correlation between iron deposition and enhanced proliferating activity in hepatitis C virus-positive hepatocellular carcinoma in Myanmar (Burma). J. Gastroenterol.<\/em><\/strong> 42:225-235, 2007. <\/span><\/p>\n

An S, Hishikawa Y<\/span><\/strong>, Koji T.: Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas\/Fas ligand and Bcl-2\/Bax systems depending upon cell types. Histochem. Cell Biol.<\/em><\/strong> 123:249-261, 2005.<\/span><\/p>\n

Hishikawa Y<\/span><\/strong>, Tamaru N, Ejima K, Hayashi T, Koji T.: Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2. Arch. Histol. Cytol.<\/em><\/strong> 67:455-464, 2004. <\/span><\/p>\n

Tamaru N, Hishikawa Y<\/span><\/strong>, Ejima K, Nagasue N, Inoue S, Muramatsu M, Hayashi T, Koji T.: Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer. Lab. Invest.<\/em><\/strong> 84:1460-1471, 2004.<\/span><\/p>\n

Damavandi E, Hishikawa Y<\/span><\/strong>, Izumi S, Shin M, Koji T.: Involvement of Bax redistribution in the induction of germ cell apoptosis in neonatal mouse testes. Acta Histochem. Cytochem.<\/em><\/strong> 35:449-459, 2002.<\/span><\/p>\n

Hishikawa Y<\/span><\/strong>, Kohno H, Ueda S, Kimoto T, Dhar DK, Kubota H, Tachibana M, Koji T, Nagasue N.: Expression of metallothionein in colorectal cancers and synchronous liver metastases. Oncology<\/em><\/strong> 61:162-167, 2001. <\/span><\/p>\n

Hishikawa Y<\/span><\/strong>, Koji T, Dhar DK, Kinugasa S, Yamaguchi M, Nagasue N.: Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus. Br. J. Cancer<\/em><\/strong> 81:712-720, 1999.<\/span><\/p>\n

Hishikawa Y<\/span><\/strong>, Abe S, Kinugasa S, Yoshimura H, Monden N, Igarashi M, Tachibana M, Nagasue N.: Overexpression of metallothionein correlates with chemoresistance to cisplatin and prognosis in esophageal cancer. Oncology<\/em><\/strong> 54: 342-347, 1997. <\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Current position: Professor, Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, Univ … <\/p>\n

\u7d9a\u304d\u3092\u8aad\u3080 »<\/a><\/p>\n","protected":false},"author":31,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false},"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/posts\/69"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/comments?post=69"}],"version-history":[{"count":107,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/posts\/69\/revisions"}],"predecessor-version":[{"id":1488,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/posts\/69\/revisions\/1488"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/media?parent=69"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/categories?post=69"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1eng\/wp-json\/wp\/v2\/tags?post=69"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}