{"id":1503,"date":"2021-04-12T19:11:03","date_gmt":"2021-04-12T10:11:03","guid":{"rendered":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/?p=1503"},"modified":"2025-11-19T13:55:42","modified_gmt":"2025-11-19T04:55:42","slug":"takumi-ishizuka","status":"publish","type":"post","link":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/takumi-ishizuka\/","title":{"rendered":"\u77f3\u585a\u3000\u5320"},"content":{"rendered":"<table style=\"width: 100%\" border=\"0\" width=\"752\" cellspacing=\"2\" cellpadding=\"0\" bgcolor=\"#FFFFFF\">\n<tbody>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\">\n<p><strong>\u73fe\u8077<\/strong>:<\/p>\n<\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\">\u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8 \u5b66\u90e8\u8b1b\u5e2b<br \/>\n\u89e3\u5256\u5b66\u8b1b\u5ea7 \u7d44\u7e54\u7d30\u80de\u5316\u5b66\u5206\u91ce<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\"><strong>\u5b66\u4f4d\u30fb\u8cc7\u683c:<\/strong><\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\">\u535a\u58eb\uff08\u5de5\u5b66\uff09\u30fb\u7532\u7a2e\u5371\u967a\u7269\u53d6\u6271\u8005\uff0c\u7b2c\u4e00\u7a2e\u885b\u751f\u7ba1\u7406\u8005<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\"><strong>\u7565\u6b74<\/strong>:<\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\">2006\u5e743\u6708\u00a0 \u6771\u4eac\u5de5\u696d\u5927\u5b66\u751f\u547d\u7406\u5de5\u5b66\u90e8 \u5352\u696d<br \/>\n2008\u5e743\u6708\u00a0 \u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u5de5\u5b66\u7cfb\u7814\u7a76\u79d1\u30d0\u30a4\u30aa\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0\u5c02\u653b\u4fee\u58eb\u8ab2\u7a0b \u4fee\u4e86<br \/>\n2008\u5e749\u6708\u00a0 \u30d1\u30eb\u30de\u5927\u5b66\uff08\u30a4\u30bf\u30ea\u30a2\uff09\u6709\u6a5f\u5316\u5b66\u7814\u7a76\u5ba4 GCOE\u5ba2\u54e1\u7814\u7a76\u54e1<br \/>\n2009\u5e744\u6708\u00a0 \u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u7279\u5225\u7814\u7a76\u54e1(DC2), \u6771\u4eac\u5927\u5b66<br \/>\n2011\u5e743\u6708\u00a0 \u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u5de5\u5b66\u7cfb\u7814\u7a76\u79d1\u5316\u5b66\u751f\u547d\u5de5\u5b66\u5c02\u653b\u535a\u58eb\u8ab2\u7a0b \u4fee\u4e86<br \/>\n2011\u5e744\u6708\u00a0 \u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u7279\u5225\u7814\u7a76\u54e1(PD), \u7406\u5316\u5b66\u7814\u7a76\u6240 \u6a2a\u6d5c\u7814\u7a76\u6240<br \/>\n2013\u5e741\u6708\u00a0 \u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8 \u6a5f\u80fd\u5236\u5fa1\u5b66\u8b1b\u5ea7 \u7269\u8cea\u79d1\u5b66\u5206\u91ce \u7279\u4efb\u52a9\u6559<br \/>\n2016\u5e744\u6708\u00a0 \u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8 \u6a5f\u80fd\u5236\u5fa1\u5b66\u8b1b\u5ea7 \u7269\u8cea\u79d1\u5b66\u5206\u91ce \u52a9\u6559<br \/>\n2021\u5e744\u6708\u00a0 \u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8 \u89e3\u5256\u5b66\u8b1b\u5ea7 \u7d44\u7e54\u7d30\u80de\u5316\u5b66\u5206\u91ce \u52a9\u6559<br \/>\n2022\u5e744\u6708\u00a0 \u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8 \u89e3\u5256\u5b66\u8b1b\u5ea7 \u7d44\u7e54\u7d30\u80de\u5316\u5b66\u5206\u91ce \u5b66\u90e8\u8b1b\u5e2b<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\"><strong>\u5c02\u9580\u5206\u91ce<\/strong>:<\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\">\u6838\u9178\u5316\u5b66<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\"><strong>\u52a0\u5165\u5b66\u4f1a<\/strong>:<\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\">\u65e5\u672c\u5316\u5b66\u4f1a\uff0c\u65e5\u672c\u6838\u9178\u5316\u5b66\u4f1a, \u65e5\u672c\u5149\u533b\u5b66\u30fb\u5149\u751f\u7269\u5b66\u4f1a, \u65e5\u672c\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u4f1a<span class=\"s1\" style=\"font-size: revert;font-family: inherit;font-weight: inherit;color: initial\">, <\/span><span style=\"font-size: revert;font-family: inherit;font-weight: inherit;color: initial\"><span style=\"font-size: revert;font-family: inherit;font-weight: inherit;color: initial\">\u65e5\u672c\u89e3\u5256\u5b66\u4f1a,<\/span><\/span>\u65e5\u672c\u9855\u5fae\u93e1\u5b66\u4f1a, \u2f47\u672c\u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u5b66\u4f1a<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\"><strong>\u7814\u7a76\u30c6\u30fc\u30de<\/strong>:<\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 13.3333%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"100\" height=\"25\">\n<div align=\"right\"><strong>\u4e3b\u8981\u8ad6\u6587<\/strong>:<\/div>\n<\/td>\n<td style=\"width: 85.7143%\" valign=\"top\" bgcolor=\"#FFFFFF\" width=\"646\" height=\"25\">Saneyoshi H*, <span style=\"text-decoration: underline\"><strong>Ishizuka T*<\/strong><\/span>, Wang S, Iwakiri R, Xu Y. Effects of Fluorine Substitution on the Human Telomeric RNA G-Quadruplex Structure. <strong>Chem. Eur. J.<\/strong> 2025, 31(39): e202501508. doi: 10.1002\/chem.202501508. *contributed equally<\/p>\n<p>Kai K, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Matsumoto J, Shimamawari K, Mori R, Fidya, Lkham-Erdene B, Kubota T, Ikenoue M, Higuchi K, Nanashima A, Hishikawa Y. Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27.\u00a0<strong>Acta Histochem. Cytochem.<\/strong> 2025, 58(2):69-79. doi: 10.1267\/ahc.25-00002.<\/p>\n<p>Higuchi K, Ikenoue M, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Kai K, Takahashi N, Kubota T, Shirouzu S, Lkham-Erdene B,<span class=\"Apple-converted-space\">\u00a0 <\/span>Mo Aung K, Nakai M, Sawaguchi A, Nanashima A, Hishikawa Y<strong>.<\/strong> SETDB1-mediated chromatin regulation in intestinal epithelial cells during intestinal ischemia-reperfusion injury. <strong>Acta Histochem. Cytochem. <\/strong>2025, 58 (1): 9-18. doi: 10.1267\/ahc.24-00061.<\/p>\n<p>Lkham-Erdene B, Choijookhuu N, Kubota T, Uto T, Mitoma S, Shirouzu S, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Kai K, Higuchi K, Mo Aung K, Batmunkh JE, Sato K, Hishikawa Y.\u00a0 Effect of hepatic lipid overload on accelerated hepatocyte proliferation promoted by HGF expression via the SphK1\/S1PR2 pathway in MCD\u2013diet mouse partial hepatectomy. <em><strong>Acta Histochem. Cytochem.<\/strong><\/em> 2024, 57(5): 175-188. doi: 10.1267\/ahc.24-00046.<\/p>\n<p class=\"p1\">Choijookhuu N, Yano K, Lkham-Erdene B, Shirouzu S, Kubota T, Fidya, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Kai K, Chosa E, Hishikawa Y. HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration. <em><strong>J. Histochem. Cytochem.<\/strong><\/em> 2024 Apr;72(4):245-264. doi: 10.1369\/00221554241241569.<\/p>\n<p class=\"p1\">Ikenoue M, Choijookhuu N, Yano K, Fidya, Takahashi N, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Shirouzu S, Yamaguma Y, Kai K, Higuchi K, Sawaguchi A, Nanashima A, Hishikawa Y. The crucial role of SETDB1 in structural and functional transformation of epithelial cells during regeneration after intestinal ischemia reperfusion injury. <em><strong>Histochem. Cell Biol.<\/strong><\/em> 2024 Apr;161(4):325-336. doi: 10.1007\/s00418-023-02263-9.<\/p>\n<p class=\"p1\">Fidya, Choijookhuu N, Ikenoue M, Yano K, Yamaguma Y, Shirouzu S, Kai K, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Hishikawa Y. Protective role of estrogen through G-protein coupled receptor 30 in a colitis mouse model. <em><strong>Histochem. Cell Biol.<\/strong><\/em> 2024 Jan;161(1):81-93. doi: 10.1007\/s00418-023-02235-z.<\/p>\n<p>Shirouzu S, Sugita N, Choijookhuu N, Yamaguma Y, Takeguchi K, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Tanaka M, Fidya, Kai K, Chosa E, Yamashita Y, Koshimoto C and Hishikawa Y. Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility. <em><strong>J. Ovarian Res.<\/strong><\/em> 2022, 15, 133. doi: 10.1186\/s13048-022-01071-4.<\/p>\n<p class=\"p1\">He Z, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Hishikawa Y, Xu Y. Click chemistry for fluorescence imaging via combination of a BODIPY-based \u2018turn-on\u2019 probe and a norbornene glucosamine. <em><strong>Chem. Commun.<\/strong><\/em> 2022, 58, 12479-12482. doi:10.1039\/D2CC05359D.<\/p>\n<p class=\"p1\">Choijookhuu N, Shibata Y, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Xu Y, Koji T, Hishikawa Y. An advanced detection system for in situ hybridization using a fluorescence resonance energy transfer\u2013based molecular beacon probe. <em><strong>Acta Histochem. Cytochem<\/strong><\/em>. 2022, 55, 119-128. doi: 10.1267\/ahc.22-00075.<\/p>\n<p class=\"p1\">Yamaguma Y, Sugita N, Choijookhuu N, Yano K, Lee D, Ikenoue M, Fidya, Shirouzu S, <span style=\"text-decoration: underline\"><strong>Ishizuka T<\/strong><\/span>, Tanaka M, Yamashita Y, Chosa E, Taniguchi N, Hishikawa Y.\u00a0 Crucial role of high-mobility group box 2 in mouse ovarian follicular development through estrogen receptor beta. <em><strong>Histochem. Cell Biol.<\/strong><\/em> 2022, 157, 359-369. doi: 10.1007\/s00418-022-02074-4.<\/p>\n<p>Yum J H*, <span style=\"text-decoration: underline\"><strong>Ishizuka T*<\/strong><\/span>, Fukumoto K, Hori D, Bao H L, Xu Y, Sugiyama H, Park S: Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin. <strong><em>ACS Biomater. Sci. Eng.<\/em><\/strong> 2021, 7, 1338-1343. doi:10.1021\/acsbiomaterials.1c00060. *contributed equally<\/p>\n<p>Bao H L, <strong><u>Ishizuka T<\/u><\/strong>, Yamashita A, Furukoji E, Asada Y, Xu Y: Improving thermodynamic stability and anticoagulant activity of a thrombin binding aptamer by incorporation of 8-trifluoromethyl-2&#8242;-deoxyguanosine. <strong><em>J. Med. Chem.<\/em><\/strong> 2021, 64, 711-718. doi:10.1021\/acs.jmedchem.0c01711.<\/p>\n<p>Sasaki S, Ma Y, <strong><u>Ishizuka T<\/u><\/strong>, Bao H-L, Hirokawa T, Xu Y, Tera M, Nagasawa K: Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex. <strong><em>RSC Advances<\/em><\/strong> 2020, 10, 43319-43323. doi:10.1039\/d0ra09413g.<\/p>\n<p>Hayasaka K, Shibata T, Sugahara A, Momotake A, Matsui T, Neya S, <strong><u>Ishizuka T<\/u><\/strong>, Xu Y, Yamamoto Y: Characterization of structure and catalytic activity of a complex between heme and an all parallel-stranded tetrameric G-quadruplex formed from DNA\/RNA chimera sequence d(TTA)r(GGG)dT. <strong><em>Bull. Chem. Soc. Jpn.<\/em><\/strong> 2020, 93, 621-629. doi:10.1246\/bcsj.20200013.<\/p>\n<p>Zhang T, Yin C, Boyd D F, Quarato G, Ingram J P, Shubina M, Ragan K B, <strong><u>Ishizuka T<\/u><\/strong>, Crawford J C, Tummers B, Rodriguez D A, Xue J, Peri S, Kaiser W J, L\u00f3pez C B, Xu Y, Upton J W, Thomas P G, Green D R, Balachandran S: Influenza virus Z-RNAs induce ZBP1-mediated necroptosis. <strong><em>Cell<\/em><\/strong> 2020, 180, 1115-1129.e1113. doi:10.1016\/j.cell.2020.02.050.<\/p>\n<p>Liu H S, <strong><u>Ishizuka T<\/u><\/strong>, Kawaguchi M, Nishii R, Kataoka H, Xu Y: A nucleoside derivative 5-vinyluridine (VrU) for imaging RNA in cells and animals. <strong><em>Bioconjug. Chem.<\/em><\/strong> 2019, 30, 2958-2966. doi:10.1021\/acs.bioconjchem.9b00643.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Bao H L, Xu Y: <sup>19<\/sup>F NMR spectroscopy for the analysis of DNA G-quadruplex structures using <sup>19<\/sup>F-labeled nucleobase. <strong><em>Methods Mol. Biol.<\/em><\/strong> 2019, 2035, 407-433. doi:10.1007\/978-1-4939-9666-7_26.<\/p>\n<p>Balasubramaniyam T, <strong><u>Ishizuka T<\/u><\/strong>, Xu Y: Stability and properties of Z-DNA containing artificial nucleobase 2&#8242;-<em>O<\/em>-methyl-8-methyl guanosine. <strong><em>Bioorg. Med. Chem.<\/em><\/strong> 2019, 27, 364-369. doi:10.1016\/j.bmc.2018.12.005.<\/p>\n<p>Balasubramaniyam T, <strong><u>Ishizuka T<\/u><\/strong>, Xiao C D, Bao H L, Xu Y: 2\u2019-<em>O<\/em>-methyl-8-methylguanosine as a Z-form RNA stabilizer for structural and functional study of Z-RNA. <strong><em>Molecules<\/em><\/strong> 2018, 23, 10.3390\/molecules23102572.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Yamashita A, Asada Y, Xu Y: Studying DNA G-quadruplex aptamer by <sup>19<\/sup>F NMR. <strong><em>ACS Omega<\/em><\/strong> 2017, 2, 8843-8848. doi:10.1021\/acsomega.7b01405.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Zhao P Y, Bao H L, Xu Y: A multi-functional guanine derivative for studying the DNA G-quadruplex structure. <strong><em>Analyst<\/em><\/strong> 2017, 142, 4083-4088. doi:10.1039\/c7an00941k.<\/p>\n<p>Xiao C D, <strong><u>Ishizuka T<\/u><\/strong>, Xu Y: Antiparallel RNA G-quadruplex formed by human telomere RNA containing 8-bromoguanosine. <strong><em>Sci. Rep.<\/em><\/strong> 2017, 7, 6695. doi:10.1038\/s41598-017-07050-w.<\/p>\n<p>Liu X, <strong><u>Ishizuka T<\/u><\/strong>, Bao H L, Wada K, Takeda Y, Iida K, Nagasawa K, Yang D, Xu Y: Structure-dependent binding of hnRNPA1 to telomere RNA. <strong><em>J. Am. Chem. Soc.<\/em><\/strong> 2017, 139, 7533-7539. doi:10.1021\/jacs.7b01599.<\/p>\n<p>Bao H L, <strong><u>Ishizuka T<\/u><\/strong>, Iwanami A, Oyoshi T, Xu Y: A simple and sensitive <sup>19<\/sup>F\u2009NMR approach for studying the interaction of RNA G\u2010quadruplex with ligand molecule and protein. <strong><em>ChemistrySelect<\/em><\/strong> 2017, 2, 4170-4175. doi:10.1002\/slct.201700711.<\/p>\n<p>Xiao C D, <strong><u>Ishizuka T<\/u><\/strong>, Zhu X Q, Li Y, Sugiyama H, Xu Y: Unusual topological RNA architecture with an eight-stranded helical fragment containing A-, G-, and U-tetrads. <strong><em>J. Am. Chem. Soc.<\/em><\/strong> 2017, 139, 2565-2568. doi:10.1021\/jacs.6b12274.<\/p>\n<p>Bao H L, <strong><u>Ishizuka T<\/u><\/strong>, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y: Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using <sup>19<\/sup>F NMR spectroscopy. <strong><em>Nucleic Acids Res.<\/em><\/strong> 2017, 45, 5501-5511. doi:10.1093\/nar\/gkx109.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Xu Y: Click chemistry takes a snapshot of DNA-RNA hybrid G-quadruplex in living cells. <strong><em>J. Nat. Sci.<\/em><\/strong> 2016, 2, e237.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Liu H S, Ito K, Xu Y: Fluorescence imaging of chromosomal DNA using click chemistry. <strong><em>Sci. Rep.<\/em><\/strong> 2016, 6, 33217. doi:10.1038\/srep33217.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Xu Y, Komiyama M: Clipping of telomere from human chromosomes using a chemistry-based artificial restriction DNA cutter. <strong><em>Curr. Protoc. Nucleic Acid Chem.<\/em><\/strong> 2015, 61, 6.13.11-16.13.13. doi:10.1002\/0471142700.nc0613s61.<\/p>\n<p>Xu Y, Suzuki Y, <strong><u>Ishizuka T<\/u><\/strong>, Xiao C D, Liu X, Hayashi T, Komiyama M: Finding a human telomere DNA-RNA hybrid G-quadruplex formed by human telomeric 6-mer RNA and 16-mer DNA using click chemistry: a protective structure for telomere end. <strong><em>Bioorg. Med. Chem.<\/em><\/strong> 2014, 22, 4419-4421. doi:10.1016\/j.bmc.2014.05.053.<\/p>\n<p>Kameshima W, <strong><u>Ishizuka T<\/u><\/strong>, Minoshima M, Yamamoto M, Sugiyama H, Xu Y, Komiyama M: Conjugation of peptide nucleic acid with a pyrrole\/imidazole polyamide to specifically recognize and cleave DNA. <strong><em>Angew. Chem. Int. Ed.<\/em><\/strong> 2013, 52, 13681-13684. doi:10.1002\/anie.201305489.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Xu Y, Komiyama M: A chemistry-based method to detect individual telomere length at a single chromosome terminus. <strong><em>J. Am. Chem. Soc.<\/em><\/strong> 2013, 135, 14-17. doi:10.1021\/ja308481c.<\/p>\n<p>Xu Y, <strong><u>Ishizuka T<\/u><\/strong>, Yang J, Ito K, Katada H, Komiyama M, Hayashi T: Oligonucleotide models of telomeric DNA and RNA form a hybrid G-quadruplex structure as a potential component of telomeres. <strong><em>J. Biol. Chem.<\/em><\/strong> 2012, 287, 41787-41796. doi:10.1074\/jbc.M112.342030.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Kimoto M, Sato A, Hirao I: Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry. <strong><em>Chem. Commun.<\/em><\/strong> 2012, 48, 10835-10837. doi:10.1039\/c2cc36293g.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Yang J, Komiyama M, Xu Y: G-rich sequence-specific recognition and scission of human genome by PNA\/DNA hybrid G-quadruplex formation. <strong><em>Angew. Chem. Int. Ed.<\/em><\/strong> 2012, 51, 7198-7202. doi:10.1002\/anie.201201176.<\/p>\n<p>Xu Y, <strong><u>Ishizuka T<\/u><\/strong>, Kimura T, Komiyama M: A U-tetrad stabilizes human telomeric RNA G-quadruplex structure. <strong><em>J. Am. Chem. Soc.<\/em><\/strong> 2010, 132, 7231-7233. doi:10.1021\/ja909708a.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Tedeschi T, Corradini R, Komiyama M, Sforza S, Marchelli R: SSB-assisted duplex invasion of preorganized PNA into double-stranded DNA. <strong><em>ChemBioChem<\/em><\/strong> 2009, 10, 2607-2612. doi:10.1002\/cbic.200900381.<\/p>\n<p>Xu Y, <strong><u>Ishizuka T<\/u><\/strong>, Kurabayashi K, Komiyama M: Consecutive formation of G-quadruplexes in human telomeric-overhang DNA: a protective capping structure for telomere ends. <strong><em>Angew. Chem. Int. Ed.<\/em><\/strong> 2009, 48, 7833-7836. doi:10.1002\/anie.200903858.<\/p>\n<p>Miyajima Y, <strong><u>Ishizuka T<\/u><\/strong>, Yamamoto Y, Sumaoka J, Komiyama M: Origin of high fidelity in target-sequence recognition by PNA-Ce(IV)\/EDTA combinations as site-selective DNA cutters. <strong><em>J. Am. Chem. Soc.<\/em><\/strong> 2009, 131, 2657-2662. doi:10.1021\/ja808290e.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Sforza S, Komiyama M: Promotion of strand invasion by utilizing entropically-favored PNA. <strong><em>Nucleic Acids Symp. Ser.<\/em><\/strong> 2009, 161-162. doi:10.1093\/nass\/nrp081.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Otani K, Sumaoka J, Komiyama M: Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein. <strong><em>Chem. Commun.<\/em><\/strong> 2009, 1225-1227. doi:10.1039\/b813975j.<\/p>\n<p>Komiyama M, Aiba Y, <strong><u>Ishizuka T<\/u><\/strong>, Sumaoka J: Solid-phase synthesis of pseudo-complementary peptide nucleic acids. <strong><em>Nat. Protoc.<\/em><\/strong> 2008, 3, 646-654. doi:10.1038\/nprot.2008.6.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Komiyama M: Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA. <strong><em>Nucleic Acids Symp. Ser.<\/em><\/strong> 2008, 141-142. doi:10.1093\/nass\/nrn072.<\/p>\n<p>Miyajima Y, <strong><u>Ishizuka T<\/u><\/strong>, Komiyama M: Mismatch recognition in PNA double-duplex invasion. <strong><em>Nucleic Acids Symp. Ser.<\/em><\/strong> 2008, 125-126. doi:10.1093\/nass\/nrn064.<\/p>\n<p><strong><u>Ishizuka T<\/u><\/strong>, Yoshida J, Yamamoto Y, Sumaoka J, Tedeschi T, Corradini R, Sforza S, Komiyama M: Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences. <strong><em>Nucleic Acids Res.<\/em><\/strong> 2008, 36, 1464-1471. doi:10.1093\/nar\/gkm1154.<\/p>\n<p>Okada S, Arayama K, Murayama R, <strong><u>Ishizuka T<\/u><\/strong>, Hara K, Hirone N, Hata T, Urabe H: Iron-catalyst-switched selective conjugate addition of grignard reagents: \u03b1,\u03b2,\u03b3,\u03b4-unsaturated amides as versatile templates for asymmetric three-component coupling processes. <strong><em>Angew. Chem. Int. Ed.<\/em><\/strong> 2008, 47, 6860-6864. doi:10.1002\/anie.200801928.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>\u73fe\u8077: \u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8 \u5b66\u90e8\u8b1b\u5e2b \u89e3\u5256\u5b66\u8b1b\u5ea7 \u7d44\u7e54\u7d30\u80de\u5316\u5b66\u5206\u91ce \u5b66\u4f4d\u30fb\u8cc7\u683c: \u535a\u58eb\uff08\u5de5\u5b66\uff09\u30fb\u7532\u7a2e\u5371\u967a\u7269\u53d6\u6271\u8005\uff0c\u7b2c\u4e00\u7a2e\u885b\u751f\u7ba1\u7406\u8005 \u7565\u6b74: 2006\u5e743\u6708\u00a0 \u6771\u4eac\u5de5\u696d\u5927\u5b66\u751f\u547d\u7406\u5de5\u5b66\u90e8 \u5352\u696d 2008\u5e743\u6708\u00a0 \u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u5de5 &hellip; <\/p>\n<p><a class=\"more-link block-button\" href=\"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/takumi-ishizuka\/\">\u7d9a\u304d\u3092\u8aad\u3080 &raquo;<\/a><\/p>\n","protected":false},"author":31,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false},"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/posts\/1503"}],"collection":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/comments?post=1503"}],"version-history":[{"count":26,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/posts\/1503\/revisions"}],"predecessor-version":[{"id":2368,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/posts\/1503\/revisions\/2368"}],"wp:attachment":[{"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/media?parent=1503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/categories?post=1503"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.med.miyazaki-u.ac.jp\/home\/anatomy1\/wp-json\/wp\/v2\/tags?post=1503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}