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1. Uncover human telomeric DNA and RNA G-quadruplex structures. Using 19F NMR, we successfully elucidated the intracellular human telomeric DNA and RNA G-quadruplex structures. Stabilize "Non-B type structures" such as G-quadruplex and Z-DNA/RNA and reveal their function.
2. Developing various chemical approaches to targeting human telomeres and telomerase for the treatment of cancer
3. Developing diagnostic technique of cancer visualization by chemistry