Combining chemistry, biological chemistry, structure biochemistry and biology, our researches focus on life molecules and their properties, such as the structure, function and molecular recognition and reactivity.

1. Uncover human telomeric DNA and RNA G-quadruplex structures. Using 19F NMR, we successfully elucidated the intracellular human telomeric DNA and RNA G-quadruplex structures. Stabilize "Non-B type structures" such as G-quadruplex and Z-DNA/RNA and reveal their function.



2. Developing various chemical approaches to targeting human telomeres and telomerase for the treatment of cancer



3. Developing diagnostic technique of cancer visualization by chemistry